Frequencies of matched and missing self allogeneic KIR/HLA combinations across recipient and index partners in HIV-1–discordant and concordant couples
| Type* . | Recipient . | Index . | DC (n = 35) . | CC (n = 35) . | DC vs CC . | |||
|---|---|---|---|---|---|---|---|---|
| KIR . | HLA . | HLA . | OR . | 95% CI . | P† . | |||
| Matched | 2DL1 | Any | C1/C2 | 32 | 54 | 0.40 | 0.15-1.07 | .066 |
| Matched | 2DL1 | Any | C2/C2 | 24 | 23 | 1.04 | 0.34-3.18 | .947 |
| Missing self | 2DL1 | C1/C2 | C1/C1 | 23 | 3 | 10.1 | 1.19-85.6 | .028 |
| Missing self | 2DL1 | C2/C2 | C1/C1 | 9 | 11 | 0.75 | 0.16-3.63 | 1.000 |
| Matched | 2DL2/2DL2 | Any | C1/C1 | 6 | 0 | NA | NA | .239 |
| Matched | 2DL2/2DL2 | Any | C1/C2 | 18 | 6 | 3.54 | 0.66-18.9 | .151 |
| Missing self | 2DL2/2DL2 | C1/C1 | C2/C2 | 0 | 0 | NA | NA | NA |
| Missing self | 2DL2/2DL2 | C1/C2 | C2/C2 | 0 | 0 | NA | NA | NA |
| Matched | 2DL2/2DL3 | Any | C1/C1 | 17 | 11 | 1.60 | 0.41-6.26 | .495 |
| Matched | 2DL2/2DL3 | Any | C1/C2 | 11 | 14 | 0.77 | 0.19-3.16 | 1.000 |
| Missing self | 2DL2/2DL3 | C1/C1 | C2/C2 | 3 | 0 | NA | NA | 1.000 |
| Missing self | 2DL2/2DL3 | C1/C2 | C2/C2 | 0 | 0 | NA | NA | NA |
| Matched | 2DL3/2DL3 | Any | C1/C1 | 14 | 9 | 1.78 | 0.39-8.09 | .710 |
| Matched | 2DL3/2DL3 | Any | C1/C2 | 3 | 34 | 0.06 | 0.01-0.46 | .001 |
| Missing self | 2DL3/2DL3 | C1/C1 | C2/C2 | 6 | 9 | 0.65 | 0.10-4.13 | 1.000 |
| Missing self | 2DL3/2DL3 | C1/C2 | C2/C2 | 9 | 6 | 1.55 | 0.24-9.88 | 1.000 |
| Type* . | Recipient . | Index . | DC (n = 35) . | CC (n = 35) . | DC vs CC . | |||
|---|---|---|---|---|---|---|---|---|
| KIR . | HLA . | HLA . | OR . | 95% CI . | P† . | |||
| Matched | 2DL1 | Any | C1/C2 | 32 | 54 | 0.40 | 0.15-1.07 | .066 |
| Matched | 2DL1 | Any | C2/C2 | 24 | 23 | 1.04 | 0.34-3.18 | .947 |
| Missing self | 2DL1 | C1/C2 | C1/C1 | 23 | 3 | 10.1 | 1.19-85.6 | .028 |
| Missing self | 2DL1 | C2/C2 | C1/C1 | 9 | 11 | 0.75 | 0.16-3.63 | 1.000 |
| Matched | 2DL2/2DL2 | Any | C1/C1 | 6 | 0 | NA | NA | .239 |
| Matched | 2DL2/2DL2 | Any | C1/C2 | 18 | 6 | 3.54 | 0.66-18.9 | .151 |
| Missing self | 2DL2/2DL2 | C1/C1 | C2/C2 | 0 | 0 | NA | NA | NA |
| Missing self | 2DL2/2DL2 | C1/C2 | C2/C2 | 0 | 0 | NA | NA | NA |
| Matched | 2DL2/2DL3 | Any | C1/C1 | 17 | 11 | 1.60 | 0.41-6.26 | .495 |
| Matched | 2DL2/2DL3 | Any | C1/C2 | 11 | 14 | 0.77 | 0.19-3.16 | 1.000 |
| Missing self | 2DL2/2DL3 | C1/C1 | C2/C2 | 3 | 0 | NA | NA | 1.000 |
| Missing self | 2DL2/2DL3 | C1/C2 | C2/C2 | 0 | 0 | NA | NA | NA |
| Matched | 2DL3/2DL3 | Any | C1/C1 | 14 | 9 | 1.78 | 0.39-8.09 | .710 |
| Matched | 2DL3/2DL3 | Any | C1/C2 | 3 | 34 | 0.06 | 0.01-0.46 | .001 |
| Missing self | 2DL3/2DL3 | C1/C1 | C2/C2 | 6 | 9 | 0.65 | 0.10-4.13 | 1.000 |
| Missing self | 2DL3/2DL3 | C1/C2 | C2/C2 | 9 | 6 | 1.55 | 0.24-9.88 | 1.000 |
Data are percentages. P values < .05 are in bold.
DC indicates HIV-1 discordant couples; CC, HIV-1 concordant couples; OR, odd's ratio; CI, confidence interval; and NA, not applicable.
According to models described by Moretta et al.11 “Matched” occurs when the specified inhibitory KIR of the recipient recognizes an HLA-C allotype present in the index (regardless of recipient HLA). “Missing self” occurs when the specified inhibitory KIR of the recipient recognizes an HLA-C allotype present in the recipient that is lacking in the index.
χ2 tests or Fisher exact tests when cells have expected counts less than 5.