Titers and specificities of FVIII-binding antibodies and results of FVIII inhibitor assays
| Study cohort/identification code . | Antibody titer against FVIII . | Binding to BDD FVIII . | Competition by FVIII . | FVIII inhibitors, (BU/mL) . |
|---|---|---|---|---|
| Healthy | ||||
| Healthy 67 | 1:320 | No | Yes | < 0.6 |
| Healthy 549 | 1:160 | No | Yes | < 0.6 |
| Healthy 226 | 1:80 | No | Yes | < 0.6 |
| Healthy 262 | 1:80 | No | Yes | < 0.6 |
| Healthy 510 | 1:80 | Yes | Yes | < 0.6 |
| Healthy 304 | 1:80 | No | Yes | < 0.6 |
| Healthy 480 | 1:80 | No | Yes | < 0.6* |
| Healthy 79 | 1:320 | No | Yes | < 1.0* |
| Healthy 217 | 1:80 | No | Yes | < 0.6 |
| Healthy 512 | 1:160 | No | Yes | < 1.0* |
| Healthy 20 | 1:80 | No | Yes | < 0.6 |
| Healthy 398 | 1:80 | No | Yes | < 0.6 |
| Healthy 62 | 1:80 | No | Yes | < 0.6 |
| Healthy 282 | 1:80 | No | Yes | < 0.6 |
| HA-noINH | ||||
| HA-noINH 7 | 1:320 | No | Yes | < 0.6 |
| HA-noINH 13 | 1:80 | No | Yes | < 0.6 |
| HA-noINH 52 | 1:80 | No | Yes | < 0.6 |
| HA-noINH 77 | 1:80 | No | Yes | < 0.6 |
| HA-ITI | ||||
| HA-ITI 5 | 1:80 | No | Yes | < 0.6 |
| Study cohort/identification code . | Antibody titer against FVIII . | Binding to BDD FVIII . | Competition by FVIII . | FVIII inhibitors, (BU/mL) . |
|---|---|---|---|---|
| Healthy | ||||
| Healthy 67 | 1:320 | No | Yes | < 0.6 |
| Healthy 549 | 1:160 | No | Yes | < 0.6 |
| Healthy 226 | 1:80 | No | Yes | < 0.6 |
| Healthy 262 | 1:80 | No | Yes | < 0.6 |
| Healthy 510 | 1:80 | Yes | Yes | < 0.6 |
| Healthy 304 | 1:80 | No | Yes | < 0.6 |
| Healthy 480 | 1:80 | No | Yes | < 0.6* |
| Healthy 79 | 1:320 | No | Yes | < 1.0* |
| Healthy 217 | 1:80 | No | Yes | < 0.6 |
| Healthy 512 | 1:160 | No | Yes | < 1.0* |
| Healthy 20 | 1:80 | No | Yes | < 0.6 |
| Healthy 398 | 1:80 | No | Yes | < 0.6 |
| Healthy 62 | 1:80 | No | Yes | < 0.6 |
| Healthy 282 | 1:80 | No | Yes | < 0.6 |
| HA-noINH | ||||
| HA-noINH 7 | 1:320 | No | Yes | < 0.6 |
| HA-noINH 13 | 1:80 | No | Yes | < 0.6 |
| HA-noINH 52 | 1:80 | No | Yes | < 0.6 |
| HA-noINH 77 | 1:80 | No | Yes | < 0.6 |
| HA-ITI | ||||
| HA-ITI 5 | 1:80 | No | Yes | < 0.6 |
Titers and specificities of FVIII-binding antibodies and results of FVIII inhibitor assays found in healthy individuals and in hemophilia A patients without FVIII inhibitors. All cases with titers ≥ 1:80 are included.
FVIII indicates factor VIII; HA-noINH, hemophilia A patients without inhibitors; and A-ITI, hemophilia A patients after successful immune tolerance induction therapy (ITI).
Samples were tested in-house with a commercially available kit.