Summary of all adverse events > 10% of patients with at least possible attribution (N = 36)
| Toxicity type, n . | Maximum grade . | Total . | All grades, % . | Grade 1 and 2, % . | Grade 3 and 4, % . | |||
|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | |||||
| Fatigue | 4 | 22 | 4 | 0 | 30 | 83 | 72 | 11 |
| Platelets | 0 | 4 | 15 | 9 | 28 | 78 | 11 | 67 |
| Neutrophils | 0 | 12 | 9 | 4 | 25 | 69 | 33 | 36 |
| Diarrhea | 10 | 11 | 0 | 0 | 21 | 58 | 58 | 0 |
| Leukocytes | 0 | 12 | 6 | 2 | 20 | 56 | 33 | 22 |
| Hemoglobin | 0 | 8 | 8 | 2 | 18 | 50 | 22 | 28 |
| Nausea | 11 | 4 | 1 | 0 | 16 | 44 | 42 | 3 |
| Anorexia | 7 | 8 | 0 | 0 | 15 | 42 | 42 | 0 |
| Taste disturbance | 7 | 3 | 0 | 0 | 10 | 28 | 28 | 0 |
| Dizziness | 7 | 0 | 0 | 0 | 7 | 19 | 19 | 0 |
| Dyspnea | 5 | 2 | 0 | 0 | 7 | 19 | 19 | 0 |
| Edema limb | 6 | 1 | 0 | 0 | 7 | 19 | 19 | 0 |
| Weight loss | 6 | 1 | 0 | 0 | 7 | 19 | 19 | 0 |
| Abdominal pain | 4 | 2 | 0 | 0 | 6 | 17 | 17 | 0 |
| Headache | 3 | 3 | 0 | 0 | 6 | 17 | 17 | 0 |
| Vomiting | 5 | 1 | 0 | 0 | 6 | 17 | 17 | 0 |
| Alopecia | 5 | 0 | 0 | 0 | 5 | 14 | 14 | 0 |
| Creatinine | 0 | 5 | 0 | 0 | 5 | 14 | 14 | 0 |
| Pneumonitis | 4 | 1 | 0 | 0 | 5 | 14 | 14 | 0 |
| Constipation | 4 | 0 | 0 | 0 | 4 | 11 | 11 | 0 |
| Dry mouth | 4 | 0 | 0 | 0 | 4 | 11 | 11 | 0 |
| Dyspepsia | 2 | 2 | 0 | 0 | 4 | 11 | 11 | 0 |
| Toxicity type, n . | Maximum grade . | Total . | All grades, % . | Grade 1 and 2, % . | Grade 3 and 4, % . | |||
|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | |||||
| Fatigue | 4 | 22 | 4 | 0 | 30 | 83 | 72 | 11 |
| Platelets | 0 | 4 | 15 | 9 | 28 | 78 | 11 | 67 |
| Neutrophils | 0 | 12 | 9 | 4 | 25 | 69 | 33 | 36 |
| Diarrhea | 10 | 11 | 0 | 0 | 21 | 58 | 58 | 0 |
| Leukocytes | 0 | 12 | 6 | 2 | 20 | 56 | 33 | 22 |
| Hemoglobin | 0 | 8 | 8 | 2 | 18 | 50 | 22 | 28 |
| Nausea | 11 | 4 | 1 | 0 | 16 | 44 | 42 | 3 |
| Anorexia | 7 | 8 | 0 | 0 | 15 | 42 | 42 | 0 |
| Taste disturbance | 7 | 3 | 0 | 0 | 10 | 28 | 28 | 0 |
| Dizziness | 7 | 0 | 0 | 0 | 7 | 19 | 19 | 0 |
| Dyspnea | 5 | 2 | 0 | 0 | 7 | 19 | 19 | 0 |
| Edema limb | 6 | 1 | 0 | 0 | 7 | 19 | 19 | 0 |
| Weight loss | 6 | 1 | 0 | 0 | 7 | 19 | 19 | 0 |
| Abdominal pain | 4 | 2 | 0 | 0 | 6 | 17 | 17 | 0 |
| Headache | 3 | 3 | 0 | 0 | 6 | 17 | 17 | 0 |
| Vomiting | 5 | 1 | 0 | 0 | 6 | 17 | 17 | 0 |
| Alopecia | 5 | 0 | 0 | 0 | 5 | 14 | 14 | 0 |
| Creatinine | 0 | 5 | 0 | 0 | 5 | 14 | 14 | 0 |
| Pneumonitis | 4 | 1 | 0 | 0 | 5 | 14 | 14 | 0 |
| Constipation | 4 | 0 | 0 | 0 | 4 | 11 | 11 | 0 |
| Dry mouth | 4 | 0 | 0 | 0 | 4 | 11 | 11 | 0 |
| Dyspepsia | 2 | 2 | 0 | 0 | 4 | 11 | 11 | 0 |