Complement system analysis in patients with HSCT-TMA
| Patient . | Transplant type . | CFI,CFH,MCP,CFB,CFR5 (direct sequence analysis) . | Recipient CFH-CFHR5 (MLPA) . | Donor CFH-CFHR5 (MLPA) . | CFH antibody (ELISA) . | CFHR1 protein analysis (western blot) . |
|---|---|---|---|---|---|---|
| 1 | autologous | normal alleles | *del(CFHR3-CFHR1) | n/a | absent | present |
| 2 | autologous | normal alleles | *del(CFHR3-CFHR1) | n/a | absent | present |
| 3 | autologous | normal alleles | *del(CFHR1-CFHR4) | n/a | absent | present |
| 4 | allogeneic | normal alleles | *del(CFHR3-CFHR1) | normal allele | present | present |
| 5 | allogeneic | normal alleles | *del(CFHR3-CFHR1) | *del(CFHR3-CFHR1) | present | present |
| 6 | allogeneic | normal alleles | normal allele | normal allele | present | present |
| Patient . | Transplant type . | CFI,CFH,MCP,CFB,CFR5 (direct sequence analysis) . | Recipient CFH-CFHR5 (MLPA) . | Donor CFH-CFHR5 (MLPA) . | CFH antibody (ELISA) . | CFHR1 protein analysis (western blot) . |
|---|---|---|---|---|---|---|
| 1 | autologous | normal alleles | *del(CFHR3-CFHR1) | n/a | absent | present |
| 2 | autologous | normal alleles | *del(CFHR3-CFHR1) | n/a | absent | present |
| 3 | autologous | normal alleles | *del(CFHR1-CFHR4) | n/a | absent | present |
| 4 | allogeneic | normal alleles | *del(CFHR3-CFHR1) | normal allele | present | present |
| 5 | allogeneic | normal alleles | *del(CFHR3-CFHR1) | *del(CFHR3-CFHR1) | present | present |
| 6 | allogeneic | normal alleles | normal allele | normal allele | present | present |
CFR, complement factor H-related gene 5.
del refers to heterozygous deletions.