Toxicity (CTC score III/IV) after induction in patients treated with L-DNR and idarubicin
| . | L-DNR . | Idarubicin . | P . |
|---|---|---|---|
| General condition | 86/223 (39) | 116/260 (45) | .18 |
| SGOT, SGPT | 32/225 (14) | 20/258 (8) | .02 |
| Arrhythmia | 1/215 (0.5) | 3/252 (1.2) | .40 |
| Cardiac function (congestive heart failure) | 3/183 (1.6) | 5/221 (2.3)* | .65 |
| Echocardiography | 0/186 (0) | 0/214 (0) | — |
| Cardiac total | 4/183 (2.1)* | 5/214 (2.3)† | 1.0 |
| Central neurotoxicity | 4/226 (1.8) | 7/261 (2.7) | .50 |
| Infection | 70/226 (31.0) | 95/261 (36.4) | .21 |
| Pulmonary toxicity | 33/204 (16) | 35/248 (14) | .54 |
| Mucositis | 58/225 (26) | 64/259 (25) | .79 |
| Skin toxicity | 8/223 (3.6) | 7/256 (2.7) | .58 |
| . | L-DNR . | Idarubicin . | P . |
|---|---|---|---|
| General condition | 86/223 (39) | 116/260 (45) | .18 |
| SGOT, SGPT | 32/225 (14) | 20/258 (8) | .02 |
| Arrhythmia | 1/215 (0.5) | 3/252 (1.2) | .40 |
| Cardiac function (congestive heart failure) | 3/183 (1.6) | 5/221 (2.3)* | .65 |
| Echocardiography | 0/186 (0) | 0/214 (0) | — |
| Cardiac total | 4/183 (2.1)* | 5/214 (2.3)† | 1.0 |
| Central neurotoxicity | 4/226 (1.8) | 7/261 (2.7) | .50 |
| Infection | 70/226 (31.0) | 95/261 (36.4) | .21 |
| Pulmonary toxicity | 33/204 (16) | 35/248 (14) | .54 |
| Mucositis | 58/225 (26) | 64/259 (25) | .79 |
| Skin toxicity | 8/223 (3.6) | 7/256 (2.7) | .58 |