Adverse events (worse ever, grades 3 or 4) according to the NCI-CTC
| Event, n (%) . | Maintenance (n = 165) . | Observation (n = 163) . |
|---|---|---|
| Anxiety | 5 (3) | 1 (0.5) |
| Cataracts | 6 (3.6) | 0 (0) |
| Constipation | 5 (3) | 0 (0) |
| Edema | 7 (4.2) | 3 (1.8) |
| Fatigue | 12 (7.2) | 3 (1.8) |
| Hyperglycemia | 23 (13.9) | 3 (1.8) |
| Hypertension | 8 (4.8) | 2 (1.2) |
| Infection* | 39 (23.6) | 25 (15.3) |
| Memory loss | 1 (0.5) | 0 (0) |
| Sensory neuropathy | 16 (9.6) | 2 (1.2) |
| Thromboembolism | 12 (7.3) | 0 (0) |
| Tremor | 6 (3.6) | 0 (0) |
| Event, n (%) . | Maintenance (n = 165) . | Observation (n = 163) . |
|---|---|---|
| Anxiety | 5 (3) | 1 (0.5) |
| Cataracts | 6 (3.6) | 0 (0) |
| Constipation | 5 (3) | 0 (0) |
| Edema | 7 (4.2) | 3 (1.8) |
| Fatigue | 12 (7.2) | 3 (1.8) |
| Hyperglycemia | 23 (13.9) | 3 (1.8) |
| Hypertension | 8 (4.8) | 2 (1.2) |
| Infection* | 39 (23.6) | 25 (15.3) |
| Memory loss | 1 (0.5) | 0 (0) |
| Sensory neuropathy | 16 (9.6) | 2 (1.2) |
| Thromboembolism | 12 (7.3) | 0 (0) |
| Tremor | 6 (3.6) | 0 (0) |
With or without neutropenia or missing.