HRQoL response analyses: areas of significant change
| Domain/item, n (%) . | Maintenance . | Observation . | P* . | |||
|---|---|---|---|---|---|---|
| Improved . | Worsened . | Improved . | Worsened . | χ2 . | M-H . | |
| Physical | 66 (42) | 54 (34) | 68 (46) | 31 (21) | .0253 | .0673 |
| Role | 90 (57) | 45 (29) | 92 (63) | 25 (17) | .0361 | .772 |
| Cognitive | 40 (25) | 85 (54) | 55 (37) | 61 (41) | .0468 | .0136 |
| Nausea | 26 (17) | 55 (35) | 31 (21) | 35 (24) | .0826 | .0442 |
| Pain | 97 (62) | 50 (32) | 82 (55) | 44 (30) | .0320 | .6688 |
| Dyspnea | 37 (24) | 91 (58) | 36 (24) | 41 (28) | .0000 | .0007 |
| Sleep | 77 (49) | 49 (31) | 56 (38) | 60 (40) | .1175 | .0432 |
| Constipation | 22 (14) | 101 (64) | 19 (13) | 35 (23) | .0000 | .0000 |
| Global | 75 (48) | 63 (40) | 78 (53) | 38 (26) | .0122 | .0580 |
| Thirst | 37 (24) | 78 (50) | 40 (27) | 39 (26) | .0000 | .0029 |
| Swelling of legs | 32 (21) | 68 (44) | 21 (14) | 30 (20) | .0000 | .0329 |
| Appetite increase | 96 (62) | 28 (18) | 64 (43) | 30 (20) | .0020 | .0197 |
| Pain in muscles | 77 (49) | 62 (39) | 69 (46) | 47 (32) | .0349 | .6152 |
| Numbness | 45 (29) | 96 (62) | 45 (30) | 59 (40) | .0000 | .0190 |
| Dry mouth | 49 (31) | 90 (58) | 58 (39) | 35 (24) | .0000 | .0000 |
| Balance problems | 15 (10) | 116 (74) | 33 (22) | 41 (28) | .0000 | .0000 |
| Sleepiness | 45 (29) | 85 (54) | 46 (31) | 61 (41) | .0300 | .1184 |
| Domain/item, n (%) . | Maintenance . | Observation . | P* . | |||
|---|---|---|---|---|---|---|
| Improved . | Worsened . | Improved . | Worsened . | χ2 . | M-H . | |
| Physical | 66 (42) | 54 (34) | 68 (46) | 31 (21) | .0253 | .0673 |
| Role | 90 (57) | 45 (29) | 92 (63) | 25 (17) | .0361 | .772 |
| Cognitive | 40 (25) | 85 (54) | 55 (37) | 61 (41) | .0468 | .0136 |
| Nausea | 26 (17) | 55 (35) | 31 (21) | 35 (24) | .0826 | .0442 |
| Pain | 97 (62) | 50 (32) | 82 (55) | 44 (30) | .0320 | .6688 |
| Dyspnea | 37 (24) | 91 (58) | 36 (24) | 41 (28) | .0000 | .0007 |
| Sleep | 77 (49) | 49 (31) | 56 (38) | 60 (40) | .1175 | .0432 |
| Constipation | 22 (14) | 101 (64) | 19 (13) | 35 (23) | .0000 | .0000 |
| Global | 75 (48) | 63 (40) | 78 (53) | 38 (26) | .0122 | .0580 |
| Thirst | 37 (24) | 78 (50) | 40 (27) | 39 (26) | .0000 | .0029 |
| Swelling of legs | 32 (21) | 68 (44) | 21 (14) | 30 (20) | .0000 | .0329 |
| Appetite increase | 96 (62) | 28 (18) | 64 (43) | 30 (20) | .0020 | .0197 |
| Pain in muscles | 77 (49) | 62 (39) | 69 (46) | 47 (32) | .0349 | .6152 |
| Numbness | 45 (29) | 96 (62) | 45 (30) | 59 (40) | .0000 | .0190 |
| Dry mouth | 49 (31) | 90 (58) | 58 (39) | 35 (24) | .0000 | .0000 |
| Balance problems | 15 (10) | 116 (74) | 33 (22) | 41 (28) | .0000 | .0000 |
| Sleepiness | 45 (29) | 85 (54) | 46 (31) | 61 (41) | .0300 | .1184 |
χ2 test compared by arm counts of improved, stable, worsened; Mantel-Haenszel (M-H) χ2 test examined whether there was a trend by treatment arm to patients with higher proportions of improved or stable HRQoL.