Genetic, morphologic, and immunophenotypical parameters of 40 cyclin D1−/SOX11+ MCL patients
| Parameter . | n . | % . |
|---|---|---|
| CCND2 translocation | ||
| IGH-CCND2 | 3/40 | 8 |
| IGK-CCND2 | 10/40 | 25 |
| IGL-CCND2 | 5/40 | 13 |
| CCND2-break* | 2/40 | 5 |
| CCND2-?† | 2/40 | 5 |
| Negative | 18/40 | 45 |
| Growth pattern | ||
| Nodular | 16/39 | 41 |
| Diffuse | 19/39 | 49 |
| Nodular/diffuse | 3/39 | 8 |
| Mantle zone | 1/39 | 3 |
| Morphology | ||
| Classical‡ | 38/39 | 97 |
| Blastoid/pleomorphic | 1/39 | 3 |
| Expression | ||
| SOX11+ | 40/40 | 100 |
| CD5+ | 39/40 | 98 |
| CD23− | 34/35 | 97 |
| CD10− | 26/27 | 96 |
| p27−/weak T cells | 29/31 | 93 |
| Cyclin D2 | 6/7 | 86 |
| Cyclin D3 | 6/8 | 75 |
| Ki67 (≥ 35%) | 9/24 | 38 |
| Parameter . | n . | % . |
|---|---|---|
| CCND2 translocation | ||
| IGH-CCND2 | 3/40 | 8 |
| IGK-CCND2 | 10/40 | 25 |
| IGL-CCND2 | 5/40 | 13 |
| CCND2-break* | 2/40 | 5 |
| CCND2-?† | 2/40 | 5 |
| Negative | 18/40 | 45 |
| Growth pattern | ||
| Nodular | 16/39 | 41 |
| Diffuse | 19/39 | 49 |
| Nodular/diffuse | 3/39 | 8 |
| Mantle zone | 1/39 | 3 |
| Morphology | ||
| Classical‡ | 38/39 | 97 |
| Blastoid/pleomorphic | 1/39 | 3 |
| Expression | ||
| SOX11+ | 40/40 | 100 |
| CD5+ | 39/40 | 98 |
| CD23− | 34/35 | 97 |
| CD10− | 26/27 | 96 |
| p27−/weak T cells | 29/31 | 93 |
| Cyclin D2 | 6/7 | 86 |
| Cyclin D3 | 6/8 | 75 |
| Ki67 (≥ 35%) | 9/24 | 38 |