Descriptive parameters for heterozygous HbAS mice in 3 treatment groups (saline, MP4OX, MP4CO) and reference data from C57BL/6 mice
| Treatment group . | Age (weeks) . | Body weight (g) . | Total Hb (g/dL) . | Spleen weight (g) . | Hb-βS (%) . |
|---|---|---|---|---|---|
| Saline | 11 ± 2 | 23.8 ± 0.6 | 10.1 ± 0.31 | 296 ± 27 | 39.4 ± 0.7 |
| MP4OX | 13 ± 1 | 25.1 ± 1.0 | 9.6 ± 0.42 | 312 ± 43 | 39.0 ± 1.0 |
| MP4CO | 11 ± 2 | 24.4 ± 0.6 | 9.8 ± 0.27 | 290 ± 30 | 39.0 ± 0.7 |
| C57BL/6 | 10 ± 1 | 26.3 ± 0.2 | 14.0 ± 0.26 | 87 ± 30 | n/m |
| Treatment group . | Age (weeks) . | Body weight (g) . | Total Hb (g/dL) . | Spleen weight (g) . | Hb-βS (%) . |
|---|---|---|---|---|---|
| Saline | 11 ± 2 | 23.8 ± 0.6 | 10.1 ± 0.31 | 296 ± 27 | 39.4 ± 0.7 |
| MP4OX | 13 ± 1 | 25.1 ± 1.0 | 9.6 ± 0.42 | 312 ± 43 | 39.0 ± 1.0 |
| MP4CO | 11 ± 2 | 24.4 ± 0.6 | 9.8 ± 0.27 | 290 ± 30 | 39.0 ± 0.7 |
| C57BL/6 | 10 ± 1 | 26.3 ± 0.2 | 14.0 ± 0.26 | 87 ± 30 | n/m |
The HbAS mice were slightly anemic with enlarged spleens, and the percentage of Hb-βS was identical in the treatment groups tested. These data indicate that disease severity was similar in each of the HbAS treatment groups studied. Values are means ± SD; n/m, not measured.