List of genes regulated by IL-4 in both human and mouse macrophages as detected with microarrays
| Symbol . | EntrezGene name . | Fold change . | Reported in M2 macrophages . |
|---|---|---|---|
| KLF4 | Kruppel-like factor 4 (gut) | 5.25 | Liao12 |
| PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 3.93 | Rehli25 |
| AQP9 | Aquaporin 9 | 3.69 | |
| IRF4 | Interferon regulatory factor 4 | 3.39 | El Chartouni14 |
| PDCD1LG2 | programmed cell death 1 ligand 2 | 3.49 | Huber17 |
| CISH | cytokine inducible SH2-containing protein | 3.09 | Rehli25 |
| CH25H | cholesterol 25-hydroxylase | 2.91 | |
| SOCS1 | suppressor of cytokine signaling 1 | 2.78 | Whyte13 |
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 2.59 | |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | 2.28 | |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 2.01 | |
| GARS | glycyl-tRNA synthetase | 1.97 | |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 1.86 | |
| MYC | v-myc myelocytomatosis viral oncogene homolog (avian) | 1.73 | Pello19 |
| SLA | Src-like-adaptor | 1.69 | |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 1.64 | |
| CD37 | CD37 molecule | −1.52 | |
| IFITM3 | interferon induced transmembrane protein 3 | −1.59 | |
| SLC9A9 | solute carrier family 9 (sodium/hydrogen exchanger), member 9 | −1.60 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | −1.76 | Rehli25 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | −1.79 | |
| KLHL6 | kelch-like 6 (Drosophila) | −1.80 | |
| APOC2 | apolipoprotein C-II | −1.80 | |
| DUSP6 | dual specificity phosphatase 6 | −1.81 | |
| SEPHS2 | selenophosphate synthetase 2 | −1.81 | |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | −1.86 | Chaitidis47 |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | −1.87 | |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | −1.94 | |
| S100A8 | S100 calcium binding protein A8 | −2.09 | Lugering48 |
| SLC40A1 | solute carrier family 40 (iron-regulated transporter), member 1 | −2.12 | |
| LPAR6 | lysophosphatidic acid receptor 6 | −2.23 | |
| AIF1 | allograft inflammatory factor 1 | −2.26 | |
| SEPP1 | selenoprotein P, plasma, 1 | −2.27 | |
| CD14 | CD14 molecule | −2.30 | Landmann49 |
| CYBB | cytochrome b-245, beta polypeptide | −2.32 | Balce50 |
| Symbol . | EntrezGene name . | Fold change . | Reported in M2 macrophages . |
|---|---|---|---|
| KLF4 | Kruppel-like factor 4 (gut) | 5.25 | Liao12 |
| PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 3.93 | Rehli25 |
| AQP9 | Aquaporin 9 | 3.69 | |
| IRF4 | Interferon regulatory factor 4 | 3.39 | El Chartouni14 |
| PDCD1LG2 | programmed cell death 1 ligand 2 | 3.49 | Huber17 |
| CISH | cytokine inducible SH2-containing protein | 3.09 | Rehli25 |
| CH25H | cholesterol 25-hydroxylase | 2.91 | |
| SOCS1 | suppressor of cytokine signaling 1 | 2.78 | Whyte13 |
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 2.59 | |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | 2.28 | |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 2.01 | |
| GARS | glycyl-tRNA synthetase | 1.97 | |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 1.86 | |
| MYC | v-myc myelocytomatosis viral oncogene homolog (avian) | 1.73 | Pello19 |
| SLA | Src-like-adaptor | 1.69 | |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 1.64 | |
| CD37 | CD37 molecule | −1.52 | |
| IFITM3 | interferon induced transmembrane protein 3 | −1.59 | |
| SLC9A9 | solute carrier family 9 (sodium/hydrogen exchanger), member 9 | −1.60 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | −1.76 | Rehli25 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | −1.79 | |
| KLHL6 | kelch-like 6 (Drosophila) | −1.80 | |
| APOC2 | apolipoprotein C-II | −1.80 | |
| DUSP6 | dual specificity phosphatase 6 | −1.81 | |
| SEPHS2 | selenophosphate synthetase 2 | −1.81 | |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | −1.86 | Chaitidis47 |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | −1.87 | |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | −1.94 | |
| S100A8 | S100 calcium binding protein A8 | −2.09 | Lugering48 |
| SLC40A1 | solute carrier family 40 (iron-regulated transporter), member 1 | −2.12 | |
| LPAR6 | lysophosphatidic acid receptor 6 | −2.23 | |
| AIF1 | allograft inflammatory factor 1 | −2.26 | |
| SEPP1 | selenoprotein P, plasma, 1 | −2.27 | |
| CD14 | CD14 molecule | −2.30 | Landmann49 |
| CYBB | cytochrome b-245, beta polypeptide | −2.32 | Balce50 |
Included markers were regulated in at least 60% of the samples and the fold change represents the average of the samples that were scored as changed.