Table 3 List of proteins regulated by... | American Society of Hematology

Table 3

List of proteins regulated by IL-4 in both human and mouse macrophages as detected with proteomics

Symbol	EntrezGene name	Fold change	Reported in M2 macrophages
MRC1	mannose receptor, C type 1	10.76	Stein¹⁵
NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	8.08
CBR1	carbonyl reductase 1	5.87
KRT1	keratin 1	5.86
EIF4E	eukaryotic translation initiation factor 4E	4.34
SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6	4.09
ATP5C1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	3.82
TFRC	transferrin receptor (p90, CD71)	3.62	Weiss¹⁶
DPYSL2	dihydropyrimidinase-like 2	3.40
OTUB1	OTU domain, ubiquitin aldehyde binding 1	2.81
ACAA2	acetyl-CoA acyltransferase 2	2.71
RPS23	ribosomal protein S23	2.67
ESD	esterase D	2.56
CYFIP1	cytoplasmic FMR1 interacting protein 1	2.36
PPT1	palmitoyl-protein thioesterase 1	2.32
GRN	granulin	2.29
ANXA4	annexin A4	2.27
RPL4	ribosomal protein L4	2.19
HSPA9	heat shock 70kDa protein 9 (mortalin)	2.12
ACTN1	actinin, alpha 1	1.96
NCL	nucleolin	1.95
UBA1	ubiquitin-like modifier activating enzyme 1	1.95
RPS15	ribosomal protein S15	1.89
VPS35	vacuolar protein sorting 35 homolog (S. cerevisiae)	1.86
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	1.68
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	1.65
DDOST	dolichyl-diphosphooligosaccharide–protein glycosyltransferase	−1.58
HMOX2	heme oxygenase (decycling) 2	−1.63
COTL1	coactosin-like 1 (Dictyostelium)	−1.64
PTPRC	protein tyrosine phosphatase, receptor type, C	−1.65
GUSB	glucuronidase, beta	−1.67
GRB2	growth factor receptor-bound protein 2	−1.71
PRDX1	peroxiredoxin 1	−1.71
COX6B1	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)	−1.73
CTSA	cathepsin A	−1.74
CLTA	clathrin, light chain A	−1.75
CTSS	cathepsin S	−1.75	Balce⁵⁰ (up-regulated)
EIF5A	eukaryotic translation initiation factor 5A	−1.75
CFL1	cofilin 1 (non-muscle)	−1.77
GLB1	galactosidase, beta 1	−1.78
PPIA	peptidylprolyl isomerase A (cyclophilin A)	−1.79
DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	−1.90
S100A11	S100 calcium binding protein A11	−1.95
PRDX3	peroxiredoxin 3	−1.96
CSTB	cystatin B (stefin B)	−2.03
GSR	glutathione reductase	−2.03
TBCB	tubulin folding cofactor B	−2.04
PYCARD	PYD and CARD domain containing	−2.17
TXNRD1	thioredoxin reductase 1	−2.24
ESYT1	extended synaptotagmin-like protein 1	−2.35
RPS10	ribosomal protein S10	−2.47
SNX2	sorting nexin 2	−2.49
TAPBP	TAP binding protein (tapasin)	−2.61
CTSD	cathepsin D	−2.71
GLS	glutaminase	−2.73
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	−2.81
PLD3	phospholipase D family, member 3	−2.84
APOE	apolipoprotein E	−2.92
HIST1H1C	histone cluster 1, H1c	−3.28
HK3	hexokinase 3 (white cell)	−3.28
NUCB1	nucleobindin 1	−3.39
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	−3.68
NAGA	N-acetylgalactosaminidase, alpha-	−4.35
ADSL	adenylosuccinate lyase	−5.84

Symbol	EntrezGene name	Fold change	Reported in M2 macrophages
MRC1	mannose receptor, C type 1	10.76	Stein¹⁵
NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	8.08
CBR1	carbonyl reductase 1	5.87
KRT1	keratin 1	5.86
EIF4E	eukaryotic translation initiation factor 4E	4.34
SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6	4.09
ATP5C1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	3.82
TFRC	transferrin receptor (p90, CD71)	3.62	Weiss¹⁶
DPYSL2	dihydropyrimidinase-like 2	3.40
OTUB1	OTU domain, ubiquitin aldehyde binding 1	2.81
ACAA2	acetyl-CoA acyltransferase 2	2.71
RPS23	ribosomal protein S23	2.67
ESD	esterase D	2.56
CYFIP1	cytoplasmic FMR1 interacting protein 1	2.36
PPT1	palmitoyl-protein thioesterase 1	2.32
GRN	granulin	2.29
ANXA4	annexin A4	2.27
RPL4	ribosomal protein L4	2.19
HSPA9	heat shock 70kDa protein 9 (mortalin)	2.12
ACTN1	actinin, alpha 1	1.96
NCL	nucleolin	1.95
UBA1	ubiquitin-like modifier activating enzyme 1	1.95
RPS15	ribosomal protein S15	1.89
VPS35	vacuolar protein sorting 35 homolog (S. cerevisiae)	1.86
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	1.68
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	1.65
DDOST	dolichyl-diphosphooligosaccharide–protein glycosyltransferase	−1.58
HMOX2	heme oxygenase (decycling) 2	−1.63
COTL1	coactosin-like 1 (Dictyostelium)	−1.64
PTPRC	protein tyrosine phosphatase, receptor type, C	−1.65
GUSB	glucuronidase, beta	−1.67
GRB2	growth factor receptor-bound protein 2	−1.71
PRDX1	peroxiredoxin 1	−1.71
COX6B1	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)	−1.73
CTSA	cathepsin A	−1.74
CLTA	clathrin, light chain A	−1.75
CTSS	cathepsin S	−1.75	Balce⁵⁰ (up-regulated)
EIF5A	eukaryotic translation initiation factor 5A	−1.75
CFL1	cofilin 1 (non-muscle)	−1.77
GLB1	galactosidase, beta 1	−1.78
PPIA	peptidylprolyl isomerase A (cyclophilin A)	−1.79
DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	−1.90
S100A11	S100 calcium binding protein A11	−1.95
PRDX3	peroxiredoxin 3	−1.96
CSTB	cystatin B (stefin B)	−2.03
GSR	glutathione reductase	−2.03
TBCB	tubulin folding cofactor B	−2.04
PYCARD	PYD and CARD domain containing	−2.17
TXNRD1	thioredoxin reductase 1	−2.24
ESYT1	extended synaptotagmin-like protein 1	−2.35
RPS10	ribosomal protein S10	−2.47
SNX2	sorting nexin 2	−2.49
TAPBP	TAP binding protein (tapasin)	−2.61
CTSD	cathepsin D	−2.71
GLS	glutaminase	−2.73
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	−2.81
PLD3	phospholipase D family, member 3	−2.84
APOE	apolipoprotein E	−2.92
HIST1H1C	histone cluster 1, H1c	−3.28
HK3	hexokinase 3 (white cell)	−3.28
NUCB1	nucleobindin 1	−3.39
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	−3.68
NAGA	N-acetylgalactosaminidase, alpha-	−4.35
ADSL	adenylosuccinate lyase	−5.84

Included markers were regulated in at least 60% of the samples and the fold change represents the average of the samples that were scored as changed.

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