Pathologic, laboratory, and cytogenetic features of EBV− PTLD
| Case . | PTLD morphology . | Kappa/lambda ISH . | SPE/UPE/IFE . | Genetic findings . |
|---|---|---|---|---|
| 1 | TA: atypical PC hyperplasia | NA | 3 IgG-κ, IgG-λ, IgM-κ, IgM-λ, κ and λ light chains | 47,XX/+3(7)/46,XX(9) |
| LN: plasmacytoma-like | NA | |||
| BM: atypical PC hyperplasia | NA | |||
| 2 | TA, LN, L: atypical PC hyperplasia | −/+ | MP* | 47,XXY or 47,XY, +X(4)/46,XY(4) |
| BM: plasma cells, lymphocytes, and histiocytes | ||||
| 3 | LN: atypical PC hyperplasia | +/+ | IgA-λ, IgG-κ | 46,XX |
| 4 | ASB: atypical PC hyperplasia | −/+ | 2 IgA-λ | 46,XX |
| LN: plasmacytoma-like | −/+ | del 13q14, del 13q34† | ||
| BM: plasma cell myeloma | NA | |||
| 5 | TA: plasmacytoma-like | +/− | NMPD | NA |
| Case . | PTLD morphology . | Kappa/lambda ISH . | SPE/UPE/IFE . | Genetic findings . |
|---|---|---|---|---|
| 1 | TA: atypical PC hyperplasia | NA | 3 IgG-κ, IgG-λ, IgM-κ, IgM-λ, κ and λ light chains | 47,XX/+3(7)/46,XX(9) |
| LN: plasmacytoma-like | NA | |||
| BM: atypical PC hyperplasia | NA | |||
| 2 | TA, LN, L: atypical PC hyperplasia | −/+ | MP* | 47,XXY or 47,XY, +X(4)/46,XY(4) |
| BM: plasma cells, lymphocytes, and histiocytes | ||||
| 3 | LN: atypical PC hyperplasia | +/+ | IgA-λ, IgG-κ | 46,XX |
| 4 | ASB: atypical PC hyperplasia | −/+ | 2 IgA-λ | 46,XX |
| LN: plasmacytoma-like | −/+ | del 13q14, del 13q34† | ||
| BM: plasma cell myeloma | NA | |||
| 5 | TA: plasmacytoma-like | +/− | NMPD | NA |
ASB indicates allograft small bowel; ISH, in situ hybridization; L, lungs; LN, lymph nodes; MP, monoclonal protein; NA, not available; NMPD, no monoclonal proteins detected; PC, plasma cell; TA, tonsils and adenoids; and UPE, urine protein electrophoresis.
One major monoclonal protein in beta and 2 additional monoclonal proteins in gamma region, not further characterized.
Detected by FISH.