Clinical and hematologic parameters of patients treated according to Pc 26.1 before and after transplantation
| UPN . | Age (y) . | Risk (class) . | Donor . | HLA . | Treatment protocol . | TNC, (×108/kg) . | Days to ANC > 0.5 × 109/L . | Days to PLT > 20 × 109/L . | Acute GVHD grade . | Chimerism (d +60, d +180) . | Rejection . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | 2 | Aunt | 1 Ag# at locus DPB1 | Pc26.1 | 4.4 | 19 | 22 | 2 | 100 D | No | Alive and cured |
| 2 | 7 | 2 | Father | Phenoidentical | Pc26.1 | 1.8 | 25 | 32 | 0 | 100 D | No | Alive and cured |
| 3 | 9 | 3 | Sister | 1 Ag# at locus DPB1 | Pc26.1 | 3.1 | 14 | 16 | 0 | 100 D | No | Alive and cured |
| 4 | 7 | 2 | Cousin | Phenoidentical | Pc26.1 | 5.2 | 19 | 22 | 0 | 100 D | No | Alive and cured |
| 5 | 8 | 3 | Brother | 1 Ag# at locus DPB1 | Pc26.1 | 2 | 20 | 24 | 0 | 100 D | No | Alive and cured |
| 6 | 15 | 3 | Mother | Phenoidentical | Pc26.1 | 5.3 | 18 | 18 | 0 | 100 D | No | Alive and cured |
| 7 | 12 | 3 | Cousin | Phenoidentical | Pc26.1 | 2.1 | 17 | 32 | 0 | 100 D | No | Alive and cured |
| 8 | 15 | 3 | Mother | 1 Ag# at locus DPB1 | Pc26.1 | 5 | 29 | 29 | 0 | 100 D | No | Alive and cured |
| 9 | 12 | 3 | Father | Phenoidentical | Pc26.1 | 6.7 | 26 | 50 | 0 | 100 D | No | Alive and cured |
| 10 | 24 | 3 | Father | Phenoidentical | Pc26.1 | 2.9 | 16 | 25 | 0 | 100 D | No | Alive and cured |
| 11 | 6.4 | 3 | Father | Phenoidentical | Pc26.1 | 4.8 | 14 | 29 | 2 | 100 D | No | Alive and cured |
| 12 | 10.3 | 3 | Brother | 1 Ag# at locus A | Pc26.1 | 5.2 | 20 | 28 | 0 | 100 D | No | Alive and cured |
| 13 | 1.4 | 1 | Father | Phenoidentical | Pc26.1 | 10 | 23 | 25 | 0 | 100 D | No | Alive and cured |
| 14 | 9 | 2 | Father | Phenoidentical | Pc26.1 | 4 | 18 | 18 | 0 | 100 D | No | Alive and cured |
| 15 | 14 | 2 | Uncle | Phenoidentical | Pc26.1 | 2.8 | 21 | 24 | 0 | 100 D | No | Alive and cured |
| 16* | 21 | 3 | Mother | Phenoidentical | Pc26.1 | 3.8 | 18 | 22 | 3 | 100 D | No | Dead (d +300) |
| UPN . | Age (y) . | Risk (class) . | Donor . | HLA . | Treatment protocol . | TNC, (×108/kg) . | Days to ANC > 0.5 × 109/L . | Days to PLT > 20 × 109/L . | Acute GVHD grade . | Chimerism (d +60, d +180) . | Rejection . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | 2 | Aunt | 1 Ag# at locus DPB1 | Pc26.1 | 4.4 | 19 | 22 | 2 | 100 D | No | Alive and cured |
| 2 | 7 | 2 | Father | Phenoidentical | Pc26.1 | 1.8 | 25 | 32 | 0 | 100 D | No | Alive and cured |
| 3 | 9 | 3 | Sister | 1 Ag# at locus DPB1 | Pc26.1 | 3.1 | 14 | 16 | 0 | 100 D | No | Alive and cured |
| 4 | 7 | 2 | Cousin | Phenoidentical | Pc26.1 | 5.2 | 19 | 22 | 0 | 100 D | No | Alive and cured |
| 5 | 8 | 3 | Brother | 1 Ag# at locus DPB1 | Pc26.1 | 2 | 20 | 24 | 0 | 100 D | No | Alive and cured |
| 6 | 15 | 3 | Mother | Phenoidentical | Pc26.1 | 5.3 | 18 | 18 | 0 | 100 D | No | Alive and cured |
| 7 | 12 | 3 | Cousin | Phenoidentical | Pc26.1 | 2.1 | 17 | 32 | 0 | 100 D | No | Alive and cured |
| 8 | 15 | 3 | Mother | 1 Ag# at locus DPB1 | Pc26.1 | 5 | 29 | 29 | 0 | 100 D | No | Alive and cured |
| 9 | 12 | 3 | Father | Phenoidentical | Pc26.1 | 6.7 | 26 | 50 | 0 | 100 D | No | Alive and cured |
| 10 | 24 | 3 | Father | Phenoidentical | Pc26.1 | 2.9 | 16 | 25 | 0 | 100 D | No | Alive and cured |
| 11 | 6.4 | 3 | Father | Phenoidentical | Pc26.1 | 4.8 | 14 | 29 | 2 | 100 D | No | Alive and cured |
| 12 | 10.3 | 3 | Brother | 1 Ag# at locus A | Pc26.1 | 5.2 | 20 | 28 | 0 | 100 D | No | Alive and cured |
| 13 | 1.4 | 1 | Father | Phenoidentical | Pc26.1 | 10 | 23 | 25 | 0 | 100 D | No | Alive and cured |
| 14 | 9 | 2 | Father | Phenoidentical | Pc26.1 | 4 | 18 | 18 | 0 | 100 D | No | Alive and cured |
| 15 | 14 | 2 | Uncle | Phenoidentical | Pc26.1 | 2.8 | 21 | 24 | 0 | 100 D | No | Alive and cured |
| 16* | 21 | 3 | Mother | Phenoidentical | Pc26.1 | 3.8 | 18 | 22 | 3 | 100 D | No | Dead (d +300) |
Ag#, antigen mismatch; ANC, absolute neutrophil count; D, % of donor chimerism; PLTs, platelets; TNC, total nucleated cells.
Cause of death was chronic GVHD gut bleeding.