Recurrently mutated genes in MDS*
| Gene . | Frequency (%) . | Reference . |
|---|---|---|
| SF3B1 | 25-30 | 36, 38 |
| TET2 | 20-25 | 32, 33 |
| RUNX1 | 10-20 | 70, 71 |
| ASXL1 | 10-15 | 34, 66 |
| SRSF2 | 10-15 | 36, 72 |
| TP53 | 5-10 | 34, 73 |
| U2AF1 | 5-10 | 36, 69 |
| NRAS/KRAS | 5-10 | 71, 74 |
| DNMT3A | 5 | 75, 76 |
| ZRSR2 | 5 | 36, 72 |
| EZH2 | 5 | 64, 77 |
| IDH1, IDH2 | 2-3 | 34, 78 |
| ETV6 | 2 | 34 |
| CBL | 1-2 | 34, 63 |
| NPM1 | 1-2 | 34, 71 |
| JAK2 | 1-2 | 34, 79 |
| SETBP1 | 1-2 | 80, 81 |
| SF3A1 | 1-2 | 36 |
| SF1 | 1-2 | 36 |
| U2AF65 | 1-2 | 36 |
| PRPF40B | 1-2 | 36 |
| Gene . | Frequency (%) . | Reference . |
|---|---|---|
| SF3B1 | 25-30 | 36, 38 |
| TET2 | 20-25 | 32, 33 |
| RUNX1 | 10-20 | 70, 71 |
| ASXL1 | 10-15 | 34, 66 |
| SRSF2 | 10-15 | 36, 72 |
| TP53 | 5-10 | 34, 73 |
| U2AF1 | 5-10 | 36, 69 |
| NRAS/KRAS | 5-10 | 71, 74 |
| DNMT3A | 5 | 75, 76 |
| ZRSR2 | 5 | 36, 72 |
| EZH2 | 5 | 64, 77 |
| IDH1, IDH2 | 2-3 | 34, 78 |
| ETV6 | 2 | 34 |
| CBL | 1-2 | 34, 63 |
| NPM1 | 1-2 | 34, 71 |
| JAK2 | 1-2 | 34, 79 |
| SETBP1 | 1-2 | 80, 81 |
| SF3A1 | 1-2 | 36 |
| SF1 | 1-2 | 36 |
| U2AF65 | 1-2 | 36 |
| PRPF40B | 1-2 | 36 |
Frequencies should be considered only as indicative, since many studies included not only patients with MDS but also patients with other types of myeloid neoplasms.