Multivariate analysis (TBI dose divided into standard and high dose)
| . | Oral BuCy vs TBI≤1250 RR (95% CI) . | IV BuCy vs TBI≤1250 RR (95% CI) . | TBI>1250 vs TBI≤1250 RR (95% CI) . | Oral BuCy vs IV BuCy RR (95% CI) . | Oral BuCy vs TBI>1250 RR (95% CI) . | IV BuCy vs TBI>1250 RR (95% CI) . | Overall P value . |
|---|---|---|---|---|---|---|---|
| aGVHD III-IV* | 0.72 (0.52-1.00) | 0.72 (0.50-1.04) | 0.99 (0.71-1.39) | 1.00 (0.67-1.49) | 0.73 (0.49-1.07) | 0.73 (0.48-1.09) | .11 |
| cGVHD† | 0.99 (0.73-1.34) | 1.28 (0.98-1.67) | 1.40 (1.10-1.79) | 0.78 (0.54-1.11) | 0.71 (0.54-0.92) | 0.91 (0.66-1.25) | .0058 |
| NRM‡ | 0.83 (0.59-1.14) | 0.67 (0.46-0.97) | 1.46 (1.03-2.07) | 1.24 (0.79-1.93) | 0.56 (0.36-0.87) | 0.46 (0.27-0.76) | .015 |
| Relapse (≤year)§ | 0.77 (0.55-1.08) | 1.01 (0.71-1.45) | 0.85 (0.58-1.28) | 0.76 (0.52-1.12) | 0.90 (0.59-1.36) | 0.90 (0.59-1.36) | .40 |
| Relapse (>1 y)§ | 1.31 (0.80-2.18) | 0.25 (0.09-0.73) | 1.23 (0.67-2.27) | 5.19 (1.85-14.57) | 1.07 (0.60-1.91) | 0.21 (0.07-0.61) | .017 |
| LFS‖ | 0.92 (0.74-1.13) | 0.74 (0.58-0.95) | 1.16 (0.93-1.45) | 1.25 (0.96-1.62) | 0.79 (0.62-1.01) | 0.63 (0.48-0.83) | .011 |
| OS‖ | 0.82 (0.66-1.02) | 0.72 (0.55-0.92) | 1.18 (0.94-1.47) | 1.15 (0.87-1.51) | 0.69 (0.54-0.90) | 0.61 (0.46-0.80) | .0017 |
| . | Oral BuCy vs TBI≤1250 RR (95% CI) . | IV BuCy vs TBI≤1250 RR (95% CI) . | TBI>1250 vs TBI≤1250 RR (95% CI) . | Oral BuCy vs IV BuCy RR (95% CI) . | Oral BuCy vs TBI>1250 RR (95% CI) . | IV BuCy vs TBI>1250 RR (95% CI) . | Overall P value . |
|---|---|---|---|---|---|---|---|
| aGVHD III-IV* | 0.72 (0.52-1.00) | 0.72 (0.50-1.04) | 0.99 (0.71-1.39) | 1.00 (0.67-1.49) | 0.73 (0.49-1.07) | 0.73 (0.48-1.09) | .11 |
| cGVHD† | 0.99 (0.73-1.34) | 1.28 (0.98-1.67) | 1.40 (1.10-1.79) | 0.78 (0.54-1.11) | 0.71 (0.54-0.92) | 0.91 (0.66-1.25) | .0058 |
| NRM‡ | 0.83 (0.59-1.14) | 0.67 (0.46-0.97) | 1.46 (1.03-2.07) | 1.24 (0.79-1.93) | 0.56 (0.36-0.87) | 0.46 (0.27-0.76) | .015 |
| Relapse (≤year)§ | 0.77 (0.55-1.08) | 1.01 (0.71-1.45) | 0.85 (0.58-1.28) | 0.76 (0.52-1.12) | 0.90 (0.59-1.36) | 0.90 (0.59-1.36) | .40 |
| Relapse (>1 y)§ | 1.31 (0.80-2.18) | 0.25 (0.09-0.73) | 1.23 (0.67-2.27) | 5.19 (1.85-14.57) | 1.07 (0.60-1.91) | 0.21 (0.07-0.61) | .017 |
| LFS‖ | 0.92 (0.74-1.13) | 0.74 (0.58-0.95) | 1.16 (0.93-1.45) | 1.25 (0.96-1.62) | 0.79 (0.62-1.01) | 0.63 (0.48-0.83) | .011 |
| OS‖ | 0.82 (0.66-1.02) | 0.72 (0.55-0.92) | 1.18 (0.94-1.47) | 1.15 (0.87-1.51) | 0.69 (0.54-0.90) | 0.61 (0.46-0.80) | .0017 |
Other significant factors in the multivariate model are noted by symbol. Bold indicates P value < .05. Abbreviations are explained in Table 3.
Sex, donor type.
Recipient age, donor and recipient sex match, and graft type.
Recipient age, KPS, donor type, time from diagnosis to transplant.
KPS and Cytogenetic risk group.
Recipient age, KPS, donor type, Cytogenetic risk group.