Top 10 networks targeted by aberrant hypomethylation in Tri21 FL-MNC
| Number . | Molecules in network . | Top functions . | Score . |
|---|---|---|---|
| 1 | ARID1B, AS3MT, BAI1, BCS1L, C12orf52, C21orf56, CDK2AP2, CUL2, FAM107B, FAM117A, FAM158A, GMDS, HNF4A, IL11RA, JINK1/2, LSR, MREG, MRPL18, NDUFV1, NUCB1, OAZ2, PABPN1, PPP1R3B, PRAF2, RFPL2, SBNO2, SLC17A5, SLMO2, SPATA6, STOML2, TBC1D23, TEF, THOC3, TLE3, VN1R1 | Cardiovascular disease, genetic disorder, neurological disease | 56 |
| 2 | AEBP1, BBC3, CARD11, CD7, CHRFAM7A, EDAR, ELF5, ETS, FABP6, HMG20B, IP6K2, KRT16, KRT17, LRDD, LSP1, NFkB, CHRN, NR1H2, NR1H3, NR1H, PIM3, PLEC, PPP1R13B, RASGRF1, RNF31, ROMO1, RRAS, RXR, SECTM1, SRPX, TRADD, TRAF1, TUBA1C, ZHX2 | Cell death, dermatological diseases & conditions, endocrine system disorders | 45 |
| 3 | GRIA1-4, AP2A1/2, ATP1A2, ATP1A4, BABAM1, CYP11B2, EPB41L1, ERK1/2, FXYD7, GABAR-A, GABRG2, GABRR1, GNAL, GPT2, HSF4, IL27RA, MRPL53, NR5A1, NSF, NTF3, PITPNM1, PRKAG1, PTGDS, RLN3, SOX7, SOX9, SOX10, STX5, TFF2, TH, TMEM109, UCN2, VAPB | Small molecule biochemistry, developmental disorder, gastrointestinal disease | 44 |
| 4 | PSMA/PSMB, PSME/PSMF, ADIPOR1, ADRM1, TUBA1A, AMPK, ASCL2, BARD1, TUBB, CLINT1, CUL7, FES, GP1BA, Hsp70, LRP, MLLT4, MST1R, ORC1, PIK3R1/2, PIK3R6, PLXNB3, PFN1/2, PSENEN, PSME1, PSME2, RAB3B, PSEN1/2, SLC39A4, SNCG, SPDEF, TCP1, TRIM9, UBB, VASP | Cell cycle, dermatological diseases & conditions, embryonic development | 32 |
| 5 | ABLIM1, ACP2, ACTG2, ADAP1, FOS/JUN, CBFA2T3, CGA/B, CGB1, CGB2, CGB7, CGBB, COL1A1/2, NR2F1/2/6, CYP17A1, CYP2D6, DIABLO, FSH, GALP, GPSM1, HAUS4, HCG, HIST1H1A-E, HMBS, MA2K4/10/12, LHB, LIF, MAP2K1-7, RPS6KB1/3, PRKACA/B/G/G1/G2, PTMS, RXRA, TGFB1/2/3, USHBP1, WNT5B, ZBED1 | Cellular movement, reproductive system development & function, nervous system development & function | 30 |
| 6 | CAPN1/10/11/, CAPN3, CASP1-12, CCNE1, CDK2, COBRA1, CRYAA, CCNA1/2, CCNE1/2, CYP27B1, DEFA1, DNAJB8, DNAJC9, E2f, ESRRB, ESR1/2, GPC1, HBG1, HIST2H3C, HIST2H4, Hsp90, Hsp22/Hsp40/Hsp90, HVCN1, KIAA1967, LIN37, OSGIN1,PRKCA/B, PNLIPRP2, SATB1, SF3B2, TFDP1, TFF1, VDR, RXR, ZDHHC11 | Cell cycle, cellular assembly & organization, embryonic development | 30 |
| 7 | ABCC1, ACR, ADCY, ADORA2A, AGAP1, AVPR2, DRD1, PTK2/2B, FOXO1, GHRHR, GIT1, Gpcr, GPR84, GPR157, GPRC5D, INS, KCNAB2, KISS1R, NPFF, P110, PAX4, PEMT, PEPCK, PRKCZ, Rab5, Ras, SRC, TBC1D3F, THRA/B, NTRK1/2/3, USP17, USP17L2, VEGF, VN1R4 | Cell signaling, nucleic acid metabolism, molecular transport | 28 |
| 8 | CBP, AFAP1, PPP3CA/B/C, CALM1, CAMK1G, CAMK2A/B, DTNA, DVL1, EPHB2, ACTA1/2, GATA2, GRIN2D, KSR1, LEFTY2, MAPK1, MYLK3, NCS1, NFATC1-4, GRIN2A-D, PIP5K1C, RHOA-H, RCVRN, REM1, RHOT2, ROCK1/2, SIT1, SLC8A2, SNX33, TNNI3, TNNT3, TPM4, TPM1/2/3/4, TUBA1A-E, UTS2 | Skeletal & muscular system, development & function, tissue morphology, cell-to-cell signaling & interaction | 26 |
| 9 | ACE, ACTA2, Akt, CD68, CD151, CD276, COL1, COL1A1/2, COL4, Cpla2, CSF2, FGA/B/G, FMOD, ITGA5, ITGB5, KLK1/3/B1, LAG3, LAMA1/5, MAP2K1/2, MFAP5, MMP26, PAK1-4, PDGFA-D, PLA2G2F, PMEL, PP2A, PROK1, PRSS1/PRSS3, RAP1A/B, SERPINF2, TPSAB1/TPSB2, VWF | Antigen presentation, inflammatory response, cardiovascular disease | 24 |
| 10 | ABR, ACTA1/2, ADHFE1, ADH, APP, AVPR1B, CKII, CNGB1, CREB1/3/5, CRYAB, CYC1, DCTN1, DHRS2, DHRS4, DMPK, DNAJB1, ENO1, FAM162A, GDP, GSK3A/B, HSPB2, NUDC, NUMBL, MAPK1/11-14, PDGFA/B, PLCB1-4, RAC1/2/3, POLR2A-L, RPL13, RYBP, PRSS1/2/3, TTLL12, WDR45, WNT1-11 | Cellular assembly & organization, organismal development, organismal injury & abnormalities | 23 |
| Number . | Molecules in network . | Top functions . | Score . |
|---|---|---|---|
| 1 | ARID1B, AS3MT, BAI1, BCS1L, C12orf52, C21orf56, CDK2AP2, CUL2, FAM107B, FAM117A, FAM158A, GMDS, HNF4A, IL11RA, JINK1/2, LSR, MREG, MRPL18, NDUFV1, NUCB1, OAZ2, PABPN1, PPP1R3B, PRAF2, RFPL2, SBNO2, SLC17A5, SLMO2, SPATA6, STOML2, TBC1D23, TEF, THOC3, TLE3, VN1R1 | Cardiovascular disease, genetic disorder, neurological disease | 56 |
| 2 | AEBP1, BBC3, CARD11, CD7, CHRFAM7A, EDAR, ELF5, ETS, FABP6, HMG20B, IP6K2, KRT16, KRT17, LRDD, LSP1, NFkB, CHRN, NR1H2, NR1H3, NR1H, PIM3, PLEC, PPP1R13B, RASGRF1, RNF31, ROMO1, RRAS, RXR, SECTM1, SRPX, TRADD, TRAF1, TUBA1C, ZHX2 | Cell death, dermatological diseases & conditions, endocrine system disorders | 45 |
| 3 | GRIA1-4, AP2A1/2, ATP1A2, ATP1A4, BABAM1, CYP11B2, EPB41L1, ERK1/2, FXYD7, GABAR-A, GABRG2, GABRR1, GNAL, GPT2, HSF4, IL27RA, MRPL53, NR5A1, NSF, NTF3, PITPNM1, PRKAG1, PTGDS, RLN3, SOX7, SOX9, SOX10, STX5, TFF2, TH, TMEM109, UCN2, VAPB | Small molecule biochemistry, developmental disorder, gastrointestinal disease | 44 |
| 4 | PSMA/PSMB, PSME/PSMF, ADIPOR1, ADRM1, TUBA1A, AMPK, ASCL2, BARD1, TUBB, CLINT1, CUL7, FES, GP1BA, Hsp70, LRP, MLLT4, MST1R, ORC1, PIK3R1/2, PIK3R6, PLXNB3, PFN1/2, PSENEN, PSME1, PSME2, RAB3B, PSEN1/2, SLC39A4, SNCG, SPDEF, TCP1, TRIM9, UBB, VASP | Cell cycle, dermatological diseases & conditions, embryonic development | 32 |
| 5 | ABLIM1, ACP2, ACTG2, ADAP1, FOS/JUN, CBFA2T3, CGA/B, CGB1, CGB2, CGB7, CGBB, COL1A1/2, NR2F1/2/6, CYP17A1, CYP2D6, DIABLO, FSH, GALP, GPSM1, HAUS4, HCG, HIST1H1A-E, HMBS, MA2K4/10/12, LHB, LIF, MAP2K1-7, RPS6KB1/3, PRKACA/B/G/G1/G2, PTMS, RXRA, TGFB1/2/3, USHBP1, WNT5B, ZBED1 | Cellular movement, reproductive system development & function, nervous system development & function | 30 |
| 6 | CAPN1/10/11/, CAPN3, CASP1-12, CCNE1, CDK2, COBRA1, CRYAA, CCNA1/2, CCNE1/2, CYP27B1, DEFA1, DNAJB8, DNAJC9, E2f, ESRRB, ESR1/2, GPC1, HBG1, HIST2H3C, HIST2H4, Hsp90, Hsp22/Hsp40/Hsp90, HVCN1, KIAA1967, LIN37, OSGIN1,PRKCA/B, PNLIPRP2, SATB1, SF3B2, TFDP1, TFF1, VDR, RXR, ZDHHC11 | Cell cycle, cellular assembly & organization, embryonic development | 30 |
| 7 | ABCC1, ACR, ADCY, ADORA2A, AGAP1, AVPR2, DRD1, PTK2/2B, FOXO1, GHRHR, GIT1, Gpcr, GPR84, GPR157, GPRC5D, INS, KCNAB2, KISS1R, NPFF, P110, PAX4, PEMT, PEPCK, PRKCZ, Rab5, Ras, SRC, TBC1D3F, THRA/B, NTRK1/2/3, USP17, USP17L2, VEGF, VN1R4 | Cell signaling, nucleic acid metabolism, molecular transport | 28 |
| 8 | CBP, AFAP1, PPP3CA/B/C, CALM1, CAMK1G, CAMK2A/B, DTNA, DVL1, EPHB2, ACTA1/2, GATA2, GRIN2D, KSR1, LEFTY2, MAPK1, MYLK3, NCS1, NFATC1-4, GRIN2A-D, PIP5K1C, RHOA-H, RCVRN, REM1, RHOT2, ROCK1/2, SIT1, SLC8A2, SNX33, TNNI3, TNNT3, TPM4, TPM1/2/3/4, TUBA1A-E, UTS2 | Skeletal & muscular system, development & function, tissue morphology, cell-to-cell signaling & interaction | 26 |
| 9 | ACE, ACTA2, Akt, CD68, CD151, CD276, COL1, COL1A1/2, COL4, Cpla2, CSF2, FGA/B/G, FMOD, ITGA5, ITGB5, KLK1/3/B1, LAG3, LAMA1/5, MAP2K1/2, MFAP5, MMP26, PAK1-4, PDGFA-D, PLA2G2F, PMEL, PP2A, PROK1, PRSS1/PRSS3, RAP1A/B, SERPINF2, TPSAB1/TPSB2, VWF | Antigen presentation, inflammatory response, cardiovascular disease | 24 |
| 10 | ABR, ACTA1/2, ADHFE1, ADH, APP, AVPR1B, CKII, CNGB1, CREB1/3/5, CRYAB, CYC1, DCTN1, DHRS2, DHRS4, DMPK, DNAJB1, ENO1, FAM162A, GDP, GSK3A/B, HSPB2, NUDC, NUMBL, MAPK1/11-14, PDGFA/B, PLCB1-4, RAC1/2/3, POLR2A-L, RPL13, RYBP, PRSS1/2/3, TTLL12, WDR45, WNT1-11 | Cellular assembly & organization, organismal development, organismal injury & abnormalities | 23 |
Genes in the network with differential methylation are in boldface type.