Top 10 networks targeted by aberrant hypermethylation in GATA1s-positive DS-TMD
| Number . | Molecules in network . | Top functions . | Score . |
|---|---|---|---|
| 1 | ADCY, ADORA3, ADRB3, FOS/JUN, ATN1, CD9, CELSR1, CXCR7, DRD2, ESR1/2, FPR3, GNAI1/2/3, GPR83, GPR101, HTR4, HTR5A, KCNA2, KCNA3, KCNJ6, LTF, NCOR1/2, NGEF, NRL, NUPR1, PI3K, RAC1/2/3, RHOA-D, RXR, S1PR3, VIPR1, VN1R4, ZFHX3 | Cell signaling, molecular transport, nucleic acid metabolism | 23 |
| 2 | ACTA2, ACTN1, ALPI/L/P, ANKRD2, APOA2, DHTR, CALM1, CAMK1G, COL1A1, COL1, CREB1/3/5, CREBL2, DCT, ERK1/2, ACTAB/C1, FSHB, GH1/2, GSN, IGFBP5, IL27RA, KCND2, KCNIP4, LEP, LHB, MYO7A, RIMS1, RLN3, SERPINA12, SGK223, SLC15A1, TFF2, TGFB, TPM1, TSEN34 | Tissue morphology, cell morphology, cellular movement | 23 |
| 3 | AEBP1, ALDH7A1, CREBP/EP300, CLEC10A, ELF2, ETS, FGA, FGA/B/G, GAS7, IFI27L2, IFNA1, IFNB1, IGHG1-4, IL24, IL25, IL12, IRF8, KLK2, LGALS7/LGALS7B, MAFG, MHC II, NFE2, NFkB, PPFIA2, PRSS1/PRSS3, PTPN2, REN, SERPINA5, SERPINF2, PRSS1/2/3, UBP1, UGCG, VWF | Cellular growth & proliferation, lymphoid tissue structure & development, cellular development | 23 |
| 4 | PSMA/PSMB, AKT1/2/3, ATAD2, CASP1-12, CYC1, DAB2IP, DLEU1, DUB, E2F1/6, ERN1, ESR1, GREB1, HIST1H3A, HIST2H3C, HIST2H4, Hsp70, HSPA1A/HSPA1B, HSPA1L, IL1, MAP2K4/8/10/12, KIAA1967, MAPK1/11/12/13/14, PEPD, POLR2H, PPARGC1A, PRR11, POLR2A-L, SF3B2, SIRT7, SKA2, SORBS2, UCHL3, USP12, VEGF, ZBTB17 | Gene expression, endocrine system development & function, small molecule biochemistry | 21 |
| 5 | ADAMTS20, ATL3, CHUK/IKBKB/IKBKG, CPVL, CSDE1, DMRT1, DMRTC1/DMRTC1B, DNTTIP2, DUPD1, E2F1, EIF4E2, ERLIN1, ETF1, FOS, GSPT2, HIST1H2AA, HIST1H2AG, HIST1H2BA, HIST1H2BJ/HIST1H2BK, HIST1H4C, HRK, HRNR, KIAA0802, LIMD1, LPPR4, MAP3K3, MARK4, PABPC1, PRDM2, PREP, SFMBT1, TBCA, TRAF6, YWHAZ, ZNF652 | Cell death, cellular development, hematological system development & function | 15 |
| 6 | ANXA8L2, ASB2, B3GALT1, CACNG5, CLC, Cyp2c70, FOXD3, GBX2, GLI1, HEBP1, HOXA3, HOXB3, HOXD13, KCTD11, L1TD1, NAT2, NAV2, NDN, NKX2-3, PAPSS2, PDZRN3, PLA2G15, POU5F1, RORA, SMPD3, SOX3, SOX7, SOX15, TCEB1, TCEB3C, TMEM100, WNT2B, WSB1, ZCCHC8 | Cellular development, cellular growth & proliferation, cell-to-cell signaling & interaction | 15 |
| 7 | CCDC82, CCL16, CRIPT, CSTF2T, DLG4, DNAH7, EPO, FAM107B, GLCE, GPX7, HGS, HNF4A, ISOC1, LRRTM2, MCTS1, MIF4GD, MRPS7, MRPS23, MSRB2, PAPOLA, PCDHA13, PDIA5, PKD1L3, PKD2L1, PRDM14, PREB, PRL, RAI2, RBMY1A1, SEC22B, TNNI3, UBQLN4, UROS, VHL, ZG16B | Cell cycle, gene expression, hematological disease | 14 |
| 8 | ACTA1/2, AGAP1, ART1, CSNK2A1/A2/B, EPS8L2, ERK, PTK2/2B, GCK, GGA3, HMGN2, INS, LGALS12, MAPK, MAZ, Mml1, MMP20, MMP24, MMP27, MMP28, MMP23A, MMP23B, MYO5B, NEUROG1, NMUR1, PCCB, PCOLCE, PDGFA/B, PRKAR1A/1B/2A/2B, PLC, KRAS/NRAS, RASA2, SLC7A7, STAT, TCOF1 | Tissue development, cellular assembly & organization, digestive system development & function | 12 |
| 9 | ATXN1, BEND2, CCDC164, CLEC4F, DDX46, DYSF, EBNA1BP2, EGLN, EGOT, FAM203A/FAM203B, GADD45G, GCAT, GLIPR2, GSTT2/GSTT2B, IGKV, IL4, IL5, ITGB1, KLHDC2, OBFC2A, PPIF, RAD54L2, RWDD2B, SASH3, SDF2L1, SERPINA3, SKA1, SLAIN1, TOMM40L, TRIM72, UBE2I, WNK2, ZNF609, ZNF777 | Cellular movement, hematological system development & function, hypersensitivity response | 12 |
| 10 | RAB7B, ART5, BST1, BTNL2, C11orf82, CD80/CD86, CECR1, CERK, CLEC10A, CLEC3B, CYBA, NCF1/2/4, DPAGT1, GAL3ST3, IFNG, IL4I1, MCHR1, MOBKL1A, MTMR11, NAD+, Pc-Plc, PHKA2, RAB36, RAB38, RAF1, RCN1, SBSN, SCN4A, SLC6A12, TCF3, TLR4, TMEM180, TREM2 | Cell morphology, cell-to-cell signaling & interaction, cellular function & maintenance | 12 |
| Number . | Molecules in network . | Top functions . | Score . |
|---|---|---|---|
| 1 | ADCY, ADORA3, ADRB3, FOS/JUN, ATN1, CD9, CELSR1, CXCR7, DRD2, ESR1/2, FPR3, GNAI1/2/3, GPR83, GPR101, HTR4, HTR5A, KCNA2, KCNA3, KCNJ6, LTF, NCOR1/2, NGEF, NRL, NUPR1, PI3K, RAC1/2/3, RHOA-D, RXR, S1PR3, VIPR1, VN1R4, ZFHX3 | Cell signaling, molecular transport, nucleic acid metabolism | 23 |
| 2 | ACTA2, ACTN1, ALPI/L/P, ANKRD2, APOA2, DHTR, CALM1, CAMK1G, COL1A1, COL1, CREB1/3/5, CREBL2, DCT, ERK1/2, ACTAB/C1, FSHB, GH1/2, GSN, IGFBP5, IL27RA, KCND2, KCNIP4, LEP, LHB, MYO7A, RIMS1, RLN3, SERPINA12, SGK223, SLC15A1, TFF2, TGFB, TPM1, TSEN34 | Tissue morphology, cell morphology, cellular movement | 23 |
| 3 | AEBP1, ALDH7A1, CREBP/EP300, CLEC10A, ELF2, ETS, FGA, FGA/B/G, GAS7, IFI27L2, IFNA1, IFNB1, IGHG1-4, IL24, IL25, IL12, IRF8, KLK2, LGALS7/LGALS7B, MAFG, MHC II, NFE2, NFkB, PPFIA2, PRSS1/PRSS3, PTPN2, REN, SERPINA5, SERPINF2, PRSS1/2/3, UBP1, UGCG, VWF | Cellular growth & proliferation, lymphoid tissue structure & development, cellular development | 23 |
| 4 | PSMA/PSMB, AKT1/2/3, ATAD2, CASP1-12, CYC1, DAB2IP, DLEU1, DUB, E2F1/6, ERN1, ESR1, GREB1, HIST1H3A, HIST2H3C, HIST2H4, Hsp70, HSPA1A/HSPA1B, HSPA1L, IL1, MAP2K4/8/10/12, KIAA1967, MAPK1/11/12/13/14, PEPD, POLR2H, PPARGC1A, PRR11, POLR2A-L, SF3B2, SIRT7, SKA2, SORBS2, UCHL3, USP12, VEGF, ZBTB17 | Gene expression, endocrine system development & function, small molecule biochemistry | 21 |
| 5 | ADAMTS20, ATL3, CHUK/IKBKB/IKBKG, CPVL, CSDE1, DMRT1, DMRTC1/DMRTC1B, DNTTIP2, DUPD1, E2F1, EIF4E2, ERLIN1, ETF1, FOS, GSPT2, HIST1H2AA, HIST1H2AG, HIST1H2BA, HIST1H2BJ/HIST1H2BK, HIST1H4C, HRK, HRNR, KIAA0802, LIMD1, LPPR4, MAP3K3, MARK4, PABPC1, PRDM2, PREP, SFMBT1, TBCA, TRAF6, YWHAZ, ZNF652 | Cell death, cellular development, hematological system development & function | 15 |
| 6 | ANXA8L2, ASB2, B3GALT1, CACNG5, CLC, Cyp2c70, FOXD3, GBX2, GLI1, HEBP1, HOXA3, HOXB3, HOXD13, KCTD11, L1TD1, NAT2, NAV2, NDN, NKX2-3, PAPSS2, PDZRN3, PLA2G15, POU5F1, RORA, SMPD3, SOX3, SOX7, SOX15, TCEB1, TCEB3C, TMEM100, WNT2B, WSB1, ZCCHC8 | Cellular development, cellular growth & proliferation, cell-to-cell signaling & interaction | 15 |
| 7 | CCDC82, CCL16, CRIPT, CSTF2T, DLG4, DNAH7, EPO, FAM107B, GLCE, GPX7, HGS, HNF4A, ISOC1, LRRTM2, MCTS1, MIF4GD, MRPS7, MRPS23, MSRB2, PAPOLA, PCDHA13, PDIA5, PKD1L3, PKD2L1, PRDM14, PREB, PRL, RAI2, RBMY1A1, SEC22B, TNNI3, UBQLN4, UROS, VHL, ZG16B | Cell cycle, gene expression, hematological disease | 14 |
| 8 | ACTA1/2, AGAP1, ART1, CSNK2A1/A2/B, EPS8L2, ERK, PTK2/2B, GCK, GGA3, HMGN2, INS, LGALS12, MAPK, MAZ, Mml1, MMP20, MMP24, MMP27, MMP28, MMP23A, MMP23B, MYO5B, NEUROG1, NMUR1, PCCB, PCOLCE, PDGFA/B, PRKAR1A/1B/2A/2B, PLC, KRAS/NRAS, RASA2, SLC7A7, STAT, TCOF1 | Tissue development, cellular assembly & organization, digestive system development & function | 12 |
| 9 | ATXN1, BEND2, CCDC164, CLEC4F, DDX46, DYSF, EBNA1BP2, EGLN, EGOT, FAM203A/FAM203B, GADD45G, GCAT, GLIPR2, GSTT2/GSTT2B, IGKV, IL4, IL5, ITGB1, KLHDC2, OBFC2A, PPIF, RAD54L2, RWDD2B, SASH3, SDF2L1, SERPINA3, SKA1, SLAIN1, TOMM40L, TRIM72, UBE2I, WNK2, ZNF609, ZNF777 | Cellular movement, hematological system development & function, hypersensitivity response | 12 |
| 10 | RAB7B, ART5, BST1, BTNL2, C11orf82, CD80/CD86, CECR1, CERK, CLEC10A, CLEC3B, CYBA, NCF1/2/4, DPAGT1, GAL3ST3, IFNG, IL4I1, MCHR1, MOBKL1A, MTMR11, NAD+, Pc-Plc, PHKA2, RAB36, RAB38, RAF1, RCN1, SBSN, SCN4A, SLC6A12, TCF3, TLR4, TMEM180, TREM2 | Cell morphology, cell-to-cell signaling & interaction, cellular function & maintenance | 12 |
Genes in the network with differential methylation are in boldface type.