Results of HLA class I restricted multivariate analyses
| HLA class I locus . | AAS considered . | Outcome . | N . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| HLA-A | AAS 116 absent | OS | 433 | 1.00 | — | |
| HLA-A | AAS 116 present | OS | 265 | 0.96 | (0.78-1.18) | .70 |
| HLA-B | AAS 116 absent | OS | 153 | 1.00 | — | |
| HLA-B | AAS 116 present | OS | 164 | 0.98 | (0.72-1.32) | .88 |
| HLA-C | AAS 116 absent | OS | 453 | 1.00 | — | |
| HLA-C | AAS 116 present | OS | 563 | 1.20 | (1.01-1.41) | .03 |
| HLA-A | AAS 99 absent | TRM | 612 | 1.00 | — | |
| HLA-A | AAS 99 present | TRM | 85 | 0.86 | (0.58-1.30) | .48 |
| HLA-B | AAS 99 absent | TRM | 308 | 1.00 | — | |
| HLA-B | AAS 99 present | TRM | 9 | 0.53 | (0.13-2.24) | .39 |
| HLA-C | AAS 99 absent | TRM | 534 | 1.00 | — | |
| HLA-C | AAS 99 present | TRM | 482 | 1.37 | (1.11-1.69) | .0038 |
| HLA-A | AAS 116 absent | Grades III-IV acute GVHD | 450 | 1.00 | — | |
| HLA-A | AAS 116 present | Grades III-IV acute GVHD | 247 | 1.18 | (0.90-1.56) | .23 |
| HLA-B | AAS 116 absent | Grades III-IV acute GVHD | 159 | 1.00 | — | |
| HLA-B | AAS 116 present | Grades III-IV acute GVHD | 157 | 1.20 | (0.82-1.75) | .35 |
| HLA-C | AAS 116 absent | Grades III-IV acute GVHD | 484 | 1.00 | — | |
| HLA-C | AAS 116 present | Grades III-IV acute GVHD | 531 | 1.45 | (1.15-1.82) | .0016 |
| HLA-A | AAS 9 absent | Chronic GVHD | 291 | 1.00 | — | |
| HLA-A | AAS 9 present | Chronic GVHD | 374 | 1.18 | (0.91-1.53) | .20 |
| HLA-B | AAS 9 absent | Chronic GVHD | 269 | 1.00 | — | |
| HLA-B | AAS 9 present | Chronic GVHD | 40 | 2.28 | (1.36-3.82) | .0018 |
| HLA-C | AAS 9 absent | Chronic GVHD | 434 | 1.00 | — | |
| HLA-C | AAS 9 present | Chronic GVHD | 552 | 1.12 | (0.91-1.39) | .28 |
| HLA class I locus . | AAS considered . | Outcome . | N . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| HLA-A | AAS 116 absent | OS | 433 | 1.00 | — | |
| HLA-A | AAS 116 present | OS | 265 | 0.96 | (0.78-1.18) | .70 |
| HLA-B | AAS 116 absent | OS | 153 | 1.00 | — | |
| HLA-B | AAS 116 present | OS | 164 | 0.98 | (0.72-1.32) | .88 |
| HLA-C | AAS 116 absent | OS | 453 | 1.00 | — | |
| HLA-C | AAS 116 present | OS | 563 | 1.20 | (1.01-1.41) | .03 |
| HLA-A | AAS 99 absent | TRM | 612 | 1.00 | — | |
| HLA-A | AAS 99 present | TRM | 85 | 0.86 | (0.58-1.30) | .48 |
| HLA-B | AAS 99 absent | TRM | 308 | 1.00 | — | |
| HLA-B | AAS 99 present | TRM | 9 | 0.53 | (0.13-2.24) | .39 |
| HLA-C | AAS 99 absent | TRM | 534 | 1.00 | — | |
| HLA-C | AAS 99 present | TRM | 482 | 1.37 | (1.11-1.69) | .0038 |
| HLA-A | AAS 116 absent | Grades III-IV acute GVHD | 450 | 1.00 | — | |
| HLA-A | AAS 116 present | Grades III-IV acute GVHD | 247 | 1.18 | (0.90-1.56) | .23 |
| HLA-B | AAS 116 absent | Grades III-IV acute GVHD | 159 | 1.00 | — | |
| HLA-B | AAS 116 present | Grades III-IV acute GVHD | 157 | 1.20 | (0.82-1.75) | .35 |
| HLA-C | AAS 116 absent | Grades III-IV acute GVHD | 484 | 1.00 | — | |
| HLA-C | AAS 116 present | Grades III-IV acute GVHD | 531 | 1.45 | (1.15-1.82) | .0016 |
| HLA-A | AAS 9 absent | Chronic GVHD | 291 | 1.00 | — | |
| HLA-A | AAS 9 present | Chronic GVHD | 374 | 1.18 | (0.91-1.53) | .20 |
| HLA-B | AAS 9 absent | Chronic GVHD | 269 | 1.00 | — | |
| HLA-B | AAS 9 present | Chronic GVHD | 40 | 2.28 | (1.36-3.82) | .0018 |
| HLA-C | AAS 9 absent | Chronic GVHD | 434 | 1.00 | — | |
| HLA-C | AAS 9 present | Chronic GVHD | 552 | 1.12 | (0.91-1.39) | .28 |