Table 4 Mean pharmacokinetic parameters... | American Society of Hematology

Table 4

Mean pharmacokinetic parameters for serum asparaginase activity

Parameter	Group A (n = 26)		Group B (n = 28)
Parameter		% coefficient of variation		% coefficient of variation
V/F (liters/m²)	12.8	55	8.3	50
k_a (h⁻¹)	0.149	62	—*
k_e (h⁻¹)	0.031	35	0.055	17
CL/F (L/h/m²)	0.40	53	0.46	49
t_1/2,z (h)	22.1	35	12.6	17
t_max (h)†	14.0	38	18.4	17
A_max (IU/mL)†	1.25	57	1.10	49

Parameter	Group A (n = 26)		Group B (n = 28)
Parameter		% coefficient of variation		% coefficient of variation
V/F (liters/m²)	12.8	55	8.3	50
k_a (h⁻¹)	0.149	62	—*
k_e (h⁻¹)	0.031	35	0.055	17
CL/F (L/h/m²)	0.40	53	0.46	49
t_1/2,z (h)	22.1	35	12.6	17
t_max (h)†	14.0	38	18.4	17
A_max (IU/mL)†	1.25	57	1.10	49

A_max, maximum serum enzyme activity; CL/F, apparent extravascular clearance of enzyme activity; t_1/2,z, apparent biological half-life of enzyme activity; t_max, time of maximum serum enzyme activity.

For group B, k_a = k_e = k.

†

Predicted values for the initial dose of the drug.

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