Cumulative incidences of hematopoietic recovery, GvHD, NRM, and OS according to donor type and study period
| Variable . | Transplant year . | |||||
|---|---|---|---|---|---|---|
| 1972–1999 . | 2000–2009 . | |||||
| HLA-identical siblings . | HLA-matched unrelated donors . | P . | HLA-identical siblings . | HLA-matched unrelated donors . | P . | |
| Graft failure | 14% (10-19) | 19% (13-26) | .24 | 6% (3-11) | 8% (4-13) | .69 |
| Acute GvHD 2-4 | .99* | .0003* | ||||
| 100 d | 37% (31-43) | 37% (29-45) | 19% (13-24) | 36% (28-43) | ||
| Chronic GvHD | .77* | .60* | ||||
| 12 mo | 15% (11-20) | 17% (11-24) | 11% (7-16) | 12% (7-18) | ||
| 60 mo | 18% (13-23) | 24% (17-32) | 20% (14-26) | 16% (11-23) | ||
| 180 mo | 32% (25-39) | 29% (20-37) | — | — | ||
| NRM | .0007* | .086* | ||||
| 12 mo | 22% (17-27) | 44% (35-52) | 14% (10-19) | 24% (18-31) | ||
| 60 mo | 27% (22-33) | 47% (38-56) | 19% (14-26) | 27% (20-35) | ||
| 180 mo | 40% (32-48) | 56% (46-65) | — | — | ||
| OS | <.0001† | .010† | ||||
| 12 mo | 75% (70-80) | 49% (41-58) | 83% (78-88) | 68% (61-75) | ||
| 60 mo | 68% (63-74) | 43% (36-52) | 76% (70-83) | 64% (57-72) | ||
| 180 mo | 55% (48-63) | 33% (25-43) | — | — | ||
| Variable . | Transplant year . | |||||
|---|---|---|---|---|---|---|
| 1972–1999 . | 2000–2009 . | |||||
| HLA-identical siblings . | HLA-matched unrelated donors . | P . | HLA-identical siblings . | HLA-matched unrelated donors . | P . | |
| Graft failure | 14% (10-19) | 19% (13-26) | .24 | 6% (3-11) | 8% (4-13) | .69 |
| Acute GvHD 2-4 | .99* | .0003* | ||||
| 100 d | 37% (31-43) | 37% (29-45) | 19% (13-24) | 36% (28-43) | ||
| Chronic GvHD | .77* | .60* | ||||
| 12 mo | 15% (11-20) | 17% (11-24) | 11% (7-16) | 12% (7-18) | ||
| 60 mo | 18% (13-23) | 24% (17-32) | 20% (14-26) | 16% (11-23) | ||
| 180 mo | 32% (25-39) | 29% (20-37) | — | — | ||
| NRM | .0007* | .086* | ||||
| 12 mo | 22% (17-27) | 44% (35-52) | 14% (10-19) | 24% (18-31) | ||
| 60 mo | 27% (22-33) | 47% (38-56) | 19% (14-26) | 27% (20-35) | ||
| 180 mo | 40% (32-48) | 56% (46-65) | — | — | ||
| OS | <.0001† | .010† | ||||
| 12 mo | 75% (70-80) | 49% (41-58) | 83% (78-88) | 68% (61-75) | ||
| 60 mo | 68% (63-74) | 43% (36-52) | 76% (70-83) | 64% (57-72) | ||
| 180 mo | 55% (48-63) | 33% (25-43) | — | — | ||