Table 1 Frequency and characteristics of... | American Society of Hematology

Table 1

Frequency and characteristics of the IGH rearrangements found by the capture/sequencing methodology in DLBCLs

Group	Cases (%)	IGH locus bkp mapping (cases)
No IGH fusion	44 (61%)
IGH fusion	28* (39%)	D_HJ_H (16); V_HJ_H (1); D_H (1); Sγ (7); Sµ (3); Sα (3)
IGH-BCL2	16† (22%)	D_HJ_H (14); V_HJ_H(1); Sα (1)
IGH-BCL6	6 (8.3%)	Sγ (4); Sμ (2)
IGH-MYC	3 (4.1%)	Sα (2); D_H (1)
IGH-CCDN1	2 (2.7%)	D_HJ_H (2)
IGH-IRF8	2 (2.7%)	Sγ (1); Sμ (1)
IGH-EBF1	1 (1.4%)	Sγ (1)
IGH-EIF4A1/TNFSF13	1 (1.4%)	Sγ (1)
Total	72

Group	Cases (%)	IGH locus bkp mapping (cases)
No IGH fusion	44 (61%)
IGH fusion	28* (39%)	D_HJ_H (16); V_HJ_H (1); D_H (1); Sγ (7); Sµ (3); Sα (3)
IGH-BCL2	16† (22%)	D_HJ_H (14); V_HJ_H(1); Sα (1)
IGH-BCL6	6 (8.3%)	Sγ (4); Sμ (2)
IGH-MYC	3 (4.1%)	Sα (2); D_H (1)
IGH-CCDN1	2 (2.7%)	D_HJ_H (2)
IGH-IRF8	2 (2.7%)	Sγ (1); Sμ (1)
IGH-EBF1	1 (1.4%)	Sγ (1)
IGH-EIF4A1/TNFSF13	1 (1.4%)	Sγ (1)
Total	72

Of 72 samples with adequate coverage, 51 are nodal DLBCLs, and 21 are extranodal tumors. The incidence of IGH fusions was 43% in the nodal subset and 28% in the extranodal group.

†

Three IGH-BCL2–positive samples had a second fusion (supplemental Table 3).

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