Table 2 Available genetically modified... | American Society of Hematology

Table 2

Available genetically modified mice illustrating the impact of a deregulated HIF system on murine erythropoiesis

Gene	Type of modification	Phenotype mice	Ref.
VHL	Liver-specific KO	Erythrocytosis	95
	Brain-specific KO	Erythrocytosis	16
	R200W mutation	Erythrocytosis	98
PHD2	Induced complete KO	Erythrocytosis	88,89
	Conditional KO (including Epo-producing cells in kidney and brain)	Erythrocytosis	92
	Heterozygosity	Mild erythrocytosis	99
HIF2α	Complete KO	Pancytopenia	100
	Induced complete KO	Anemia	82
	Liver-specific KO	Anemia	85*
	Liver-specific KO	Anemia	83*
	Kidney-specific KO	Anemia	83
	Heterozygosity	Mild anemia	Unpublished
	G536W mutation	Erythrocytosis	86

Gene	Type of modification	Phenotype mice	Ref.
VHL	Liver-specific KO	Erythrocytosis	95
	Brain-specific KO	Erythrocytosis	16
	R200W mutation	Erythrocytosis	98
PHD2	Induced complete KO	Erythrocytosis	88,89
	Conditional KO (including Epo-producing cells in kidney and brain)	Erythrocytosis	92
	Heterozygosity	Mild erythrocytosis	99
HIF2α	Complete KO	Pancytopenia	100
	Induced complete KO	Anemia	82
	Liver-specific KO	Anemia	85*
	Liver-specific KO	Anemia	83*
	Kidney-specific KO	Anemia	83
	Heterozygosity	Mild anemia	Unpublished
	G536W mutation	Erythrocytosis	86

KO, knockout.

In anemic mice and during early postnatal development.