Table 4

Antibody titers in subjects with preexisting high specific binding anti-VWF antibodies

SubjectGenderAge, yBinding anti-VWF Ab titer
ScreeningPreinfusion 2Study termination
21 23 1:1280 1:5120* 1:5120 
23 19 1:1280 NA 1:2560 
SubjectGenderAge, yBinding anti-VWF Ab titer
ScreeningPreinfusion 2Study termination
21 23 1:1280 1:5120* 1:5120 
23 19 1:1280 NA 1:2560 
*

Postinfusion with pdVWF-pdFVII and preinfusion with rVWF-rFVIII.

Subject 23 received only rVWF-rFVIII (not enrolled in the crossover cohort).

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