Comparison of myocardial T2* change from baseline in patients treated with deferasirox or DFO for 1 year
| . | Deferasirox . | DFO . | All patients . |
|---|---|---|---|
| Per-protocol population | n = 91 | n = 81 | n = 172 |
| Gmean T2* (CV) at baseline | 11.2 (32.6) | 11.6 (30.7) | 11.4 (31.7) |
| Gmean T2* (CV) at EOS† | 12.6 (42.6) | 12.3 (34.7) | 12.5 (38.9) |
| Gmean ratio of month 12/baseline (95% CI) | 1.12 (1.07, 1.18) | 1.07 (1.02, 1.11) | 1.10 (1.06, 1.13) |
| Ratio of Gmean ratios of deferasirox vs DFO | — | — | 1.056 |
| Repeated 95% CI of the ratio of Gmean ratios | — | — | (0.998, 1.133) |
| P value for superiority‡ | — | — | .057 |
| Intention-to-treat population | n = 92 | n = 88 | n = 180 |
| Gmean T2* (CV) at baseline | 11.2 (31.9) | 11.6 (32.9) | 11.4 (32.4) |
| Gmean T2* (CV) at EOS† | 12.5 (43.0) | 12.0 (36.3) | 12.2 (39.7) |
| Gmean ratio of month 12/baseline (95% CI) | 1.12 (1.07, 1.18) | 1.06 (1.02, 1.11) | 1.09 (1.06, 1.13) |
| Ratio of Gmean ratios of deferasirox vs DFO | — | — | 1.055 |
| Repeated 95% CI of the ratio of Gmean ratios | — | — | (0.999, 1.129) |
| P value for superiority‡ | — | — | .054 |
| . | Deferasirox . | DFO . | All patients . |
|---|---|---|---|
| Per-protocol population | n = 91 | n = 81 | n = 172 |
| Gmean T2* (CV) at baseline | 11.2 (32.6) | 11.6 (30.7) | 11.4 (31.7) |
| Gmean T2* (CV) at EOS† | 12.6 (42.6) | 12.3 (34.7) | 12.5 (38.9) |
| Gmean ratio of month 12/baseline (95% CI) | 1.12 (1.07, 1.18) | 1.07 (1.02, 1.11) | 1.10 (1.06, 1.13) |
| Ratio of Gmean ratios of deferasirox vs DFO | — | — | 1.056 |
| Repeated 95% CI of the ratio of Gmean ratios | — | — | (0.998, 1.133) |
| P value for superiority‡ | — | — | .057 |
| Intention-to-treat population | n = 92 | n = 88 | n = 180 |
| Gmean T2* (CV) at baseline | 11.2 (31.9) | 11.6 (32.9) | 11.4 (32.4) |
| Gmean T2* (CV) at EOS† | 12.5 (43.0) | 12.0 (36.3) | 12.2 (39.7) |
| Gmean ratio of month 12/baseline (95% CI) | 1.12 (1.07, 1.18) | 1.06 (1.02, 1.11) | 1.09 (1.06, 1.13) |
| Ratio of Gmean ratios of deferasirox vs DFO | — | — | 1.055 |
| Repeated 95% CI of the ratio of Gmean ratios | — | — | (0.999, 1.129) |
| P value for superiority‡ | — | — | .054 |