Change in cardiac iron concentration in response to chelation as a function of baseline LIC
| Base LIC . | Agent . | Base cardiac T2* (ms) . | Change cardiac Fe . | Base LVEF . | 12-mo LVEF . | Reference . |
|---|---|---|---|---|---|---|
| Low (<7) | DFO | 13.5 | −12.06% | 68.4% | 68.9% | 9 |
| DFO | 13.1 | −10.14% | 66.4% | 66.4% | 1 | |
| DFP | 13 | −25.79% | 69.7% | 72.8% | 9 | |
| DFX | 12.7 | −27.87% | 66.9% | 66.3% | 1 | |
| DFP+DFO | 11 | −41.20% | 65.8% | 68.4%‖ | 8 | |
| Medium (7-15) | DFO | 12.4 | −25.01% | 64.7% | 65.3% | 8 |
| DFO | 13.2 | −13.03% | 66.4% | 66.4% | 1 | |
| DFX | 10.5 | −28.35% | 62.1% | 62.7% | 2 | |
| DFX | 12 | −18.57% | 66.9% | 66.3% | 1 | |
| DFP+DFO | 5.7 | −32.85% | 51.2% | 65.6% | 10 | |
| High (>15) | DFO | 11.1 | −5.23% | 66.4% | 66.4% | 1 |
| DFX | 10.8 | −9.30% | 66.9% | 66.3% | 1 | |
| DFX | 8.25 | 12.33% | 62.4% | 62.1% | 2 | |
| DFX | 11.2 | −16.63 | 67.5% | 67.7% | 6 |
| Base LIC . | Agent . | Base cardiac T2* (ms) . | Change cardiac Fe . | Base LVEF . | 12-mo LVEF . | Reference . |
|---|---|---|---|---|---|---|
| Low (<7) | DFO | 13.5 | −12.06% | 68.4% | 68.9% | 9 |
| DFO | 13.1 | −10.14% | 66.4% | 66.4% | 1 | |
| DFP | 13 | −25.79% | 69.7% | 72.8% | 9 | |
| DFX | 12.7 | −27.87% | 66.9% | 66.3% | 1 | |
| DFP+DFO | 11 | −41.20% | 65.8% | 68.4%‖ | 8 | |
| Medium (7-15) | DFO | 12.4 | −25.01% | 64.7% | 65.3% | 8 |
| DFO | 13.2 | −13.03% | 66.4% | 66.4% | 1 | |
| DFX | 10.5 | −28.35% | 62.1% | 62.7% | 2 | |
| DFX | 12 | −18.57% | 66.9% | 66.3% | 1 | |
| DFP+DFO | 5.7 | −32.85% | 51.2% | 65.6% | 10 | |
| High (>15) | DFO | 11.1 | −5.23% | 66.4% | 66.4% | 1 |
| DFX | 10.8 | −9.30% | 66.9% | 66.3% | 1 | |
| DFX | 8.25 | 12.33% | 62.4% | 62.1% | 2 | |
| DFX | 11.2 | −16.63 | 67.5% | 67.7% | 6 |
Base LIC in mg/g dry weight liver. Reference 2 classed based on “responder” ∼ medium and “nonresponder” ∼ high. Cardiac Fe change calculated in Pennell et al1 from change in T2* using [Fe] = 45 × (T2*)−1.22. Pre to 12-mo LVEF cells in bold italics are significantly different. P < .01; ‖P < .05.