Table 2 Cases with PLCG1 mutation and... | American Society of Hematology

Table 2

Cases with PLCG1 mutation and NFAT, p50, p52, and Ki67 IHC data

Case	Dx	PLCG1	mut detection	NFAT	p50	p52	Ki67
02	T	MUT	NGS/Sanger/qPCR	pos	pos	pos	ND
06	E, T	MUT	NGS/Sanger/qPCR	pos	pos	pos	15
08	E	MUT*	NGS/Sanger	pos	neg/pos	pos	2
14	T	MUT	qPCR/Sanger	pos	pos	pos	60
15	Fl, T	MUT	qPCR/Sanger	ND	ND	ND	ND
25	T	WT		neg	neg	neg	90
27	T	WT		pos/neg	pos	neg	5
28	T	MUT	qPCR	ND	ND	ND	ND
30-1	T	MUT	qPCR	pos/neg	pos	pos	70
30-2	T	MUT	qPCR	pos	pos	pos	70
34	SS	MUT	qPCR	ND	ND	ND	ND
36	E, Fl, T	WT		neg	neg	neg	ND
37	T	WT		neg	pos	pos	5
38-1	E, Fl, T	MUT	qPCR	pos/neg	ND	pos	ND
38-2	E, Fl, T	WT		neg	ND	pos	30
38-3	E, Fl, T	MUT	qPCR	neg	pos	pos	85
38-4	E, Fl, T	MUT	qPCR	pos/neg	pos	pos/neg	90
39	T	WT		neg	neg	pos	ND
40	SS	WT		pos	pos	pos	ND
42	E, T	WT		pos/neg	pos	pos/neg	ND
43	Fl, T	WT		pos	pos	pos	10
44	T	WT		neg	pos	neg	2
45	T	WT		neg	neg	pos	30
47	T	WT		neg	pos	pos/neg	60
48	E, Fl, T	WT		neg	pos	pos	25
49	Fl, T	MUT	qPCR	neg	pos	pos	35
50	T	WT		neg	pos	neg	5

Case	Dx	PLCG1	mut detection	NFAT	p50	p52	Ki67
02	T	MUT	NGS/Sanger/qPCR	pos	pos	pos	ND
06	E, T	MUT	NGS/Sanger/qPCR	pos	pos	pos	15
08	E	MUT*	NGS/Sanger	pos	neg/pos	pos	2
14	T	MUT	qPCR/Sanger	pos	pos	pos	60
15	Fl, T	MUT	qPCR/Sanger	ND	ND	ND	ND
25	T	WT		neg	neg	neg	90
27	T	WT		pos/neg	pos	neg	5
28	T	MUT	qPCR	ND	ND	ND	ND
30-1	T	MUT	qPCR	pos/neg	pos	pos	70
30-2	T	MUT	qPCR	pos	pos	pos	70
34	SS	MUT	qPCR	ND	ND	ND	ND
36	E, Fl, T	WT		neg	neg	neg	ND
37	T	WT		neg	pos	pos	5
38-1	E, Fl, T	MUT	qPCR	pos/neg	ND	pos	ND
38-2	E, Fl, T	WT		neg	ND	pos	30
38-3	E, Fl, T	MUT	qPCR	neg	pos	pos	85
38-4	E, Fl, T	MUT	qPCR	pos/neg	pos	pos/neg	90
39	T	WT		neg	neg	pos	ND
40	SS	WT		pos	pos	pos	ND
42	E, T	WT		pos/neg	pos	pos/neg	ND
43	Fl, T	WT		pos	pos	pos	10
44	T	WT		neg	pos	neg	2
45	T	WT		neg	neg	pos	30
47	T	WT		neg	pos	pos/neg	60
48	E, Fl, T	WT		neg	pos	pos	25
49	Fl, T	MUT	qPCR	neg	pos	pos	35
50	T	WT		neg	pos	neg	5

Ki67 data correspond to percentage of positive cells. S345F mutation was not detected in the rest of the samples analyzed; the data are not included in this table.

E, erythrodermic; Fl, folliculotropic MF; MUT, S345F mutation; MUT*, S520F mutation; ND, no data; neg, negative (<10%); NGS, next-generation sequencing; pos, positive (>50%); pos/neg, >10% and <50% positive cells; T, classic MF with tumors.

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