Table 4

Biomarker values in all ALPS-FAS patients

BiomarkersProbandRelativeOverall
α/β DNT percentage median (Q1, Q3) N = 140 (normal <1.5%) 6.9% (3.9, 11.7) 4.4% (2.7, 7.8) 5.9% (3.12, 9.0) 
α/β DNT number median (Q1, Q3) N = 140 (normal ≤25 cells/mm3) 123 (75, 438) 88 (56, 180) 112 (64, 245) 
Vitamin B12, pg/mL* median (Q1, Q3) N = 142 (normal <1320 pg/mL) 3712 (1714, 4000) 1716 (1008, 3786) 2798 (1351, 4000) 
IL-10, pg/mL median (Q1, Q3) n = 115 (normal ≤20 pg/mL) 134 (72, 226) 80 (50, 127) 96 (57, 187) 
sFASL, pg/mL median (Q1, Q3) N = 139 (normal ≤200 pg/mL) 1478 (870, 2692) 837 (341, 1394) 1146 (581, 1995) 
BiomarkersProbandRelativeOverall
α/β DNT percentage median (Q1, Q3) N = 140 (normal <1.5%) 6.9% (3.9, 11.7) 4.4% (2.7, 7.8) 5.9% (3.12, 9.0) 
α/β DNT number median (Q1, Q3) N = 140 (normal ≤25 cells/mm3) 123 (75, 438) 88 (56, 180) 112 (64, 245) 
Vitamin B12, pg/mL* median (Q1, Q3) N = 142 (normal <1320 pg/mL) 3712 (1714, 4000) 1716 (1008, 3786) 2798 (1351, 4000) 
IL-10, pg/mL median (Q1, Q3) n = 115 (normal ≤20 pg/mL) 134 (72, 226) 80 (50, 127) 96 (57, 187) 
sFASL, pg/mL median (Q1, Q3) N = 139 (normal ≤200 pg/mL) 1478 (870, 2692) 837 (341, 1394) 1146 (581, 1995) 

Q1 is the 25th percentile; Q3 is the 75th percentile.*Number of available markers for any patient varied by whether a specific marker was tested for that particular patient at a specific visit. A median value was taken for individuals with >1 value.

*

Maximum serum B12 level used was 4000.

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