Kinases and phosphatases with regulated phosphosites within the 6 clusters in Figure 2A
| Gene name . | Regulation profile . | |||||
|---|---|---|---|---|---|---|
| Cluster 1 . | Cluster 2 . | Cluster 3 . | Cluster 4 . | Cluster 5 . | Cluster 6 . | |
| Tyrosine kinases | ||||||
| ABL2 | S783;S817;S820 | T818 | ||||
| EPHA2 | S579 | S897;T898;S901 | ||||
| FYN | S21 | |||||
| KDR | S1227 | S1235;T1238 | ||||
| PEAK1 | S902 | S826 | T852;S854 | S854;S1214;S1217;S1250 | ||
| SGK223 | S694 | T1223 | ||||
| Serine/threonine kinases | ||||||
| AAK1 | S637 | S846 | ||||
| ACVRL1 | S155 | S160 | ||||
| ADRBK1 | S670 | |||||
| AKT3 | S472;S476 | |||||
| CAMK2D | S315;S318;S319 | S330;T337 | ||||
| CAMK2G | S315;S319 | |||||
| CDC42BPA | S1545 | |||||
| CDC42BPB | S1693 | |||||
| CDK13 | T1056;T1058 | |||||
| CDK14 | S95 | |||||
| CDK17 | S75;S92;S137;S176;S180 | |||||
| DAPK3 | T306 | |||||
| EIF2AK3 | S715;S719 | |||||
| GSK3B | T390 | |||||
| ILK | T172;T173 | |||||
| KSR1 | T268;T272;S332 | |||||
| LATS1 | S464 | |||||
| LIMK2 | S293;S298 | |||||
| MAP2K2 | S293;S295 | |||||
| MAP2K7 | S55;S61 | |||||
| MAP3K11 | T702;S705;T708 | S789;S793 | ||||
| MAP3K3 | S337;S340 | S340 | ||||
| MAP4K4 | S900 | S602 | ||||
| MAP4K5 | S433 | |||||
| MAPK1 | T185;Y187 | T185;Y187 | ||||
| MAPK3 | Y204 | T202;Y204 | ||||
| MAPK14 | T180;Y182 | Y182 | ||||
| MARK2 | S40;S631 | S390 | ||||
| MARK3 | S391 | |||||
| MAST2 | S876;S1256 | S1264 | S209 | |||
| MAST4 | S2523 | S261;S917;S1286;S1373;T1393;S1470;S1526;S2445 | S266;S1373;S1380;S1782 | S1950 | ||
| MINK1 | S778;S782 | |||||
| MLTK | S648 | S633 | ||||
| NRBP1 | T232 | S2 | ||||
| PAK2 | S197 | S55 | ||||
| PRKAA1 | S486;T490;S527 | |||||
| PRKCD | S304 | |||||
| PRKD1 | S237;S549;S742^ | S205;S208;S219;S249; S397^;S401^ | ||||
| PRKD2 | S203;S518 | S375;S710;S876 | S197;S214 | S198 | ||
| PRKD3 | S213;S216;S735^ | S391^;S395^ | ||||
| PRPF4B | S578;S580 | |||||
| PTK2 | Y861 | |||||
| RIPK1 | S320 | S320;S330 | ||||
| RIPK2 | S178 | S531 | S363 | |||
| RIPK3 | S410 | |||||
| ROCK2 | S1374 | |||||
| RPS6KA3 | T365;S369 | S715 | ||||
| RPS6KB1 | S441;T444;S447 | S427 | ||||
| SLK | S779 | |||||
| STK10 | S13;T14 | S514 | T952 | S417 | ||
| STK17A | S28 | |||||
| STK24 | S4 | |||||
| STRADA | S46 | |||||
| TAOK1 | S9 | |||||
| TAOK2 | S9 | |||||
| TAOK3 | S324 | S331 | ||||
| TNIK | S640;S678;S680 | |||||
| TRIO | S1785;S1786 | S2477 | S2455;S2459 | |||
| WNK1 | S167;S2372 | S174 | ||||
| Phosphatases | ||||||
| CTDSPL2 | S104 | |||||
| DUSP6 | S351 | |||||
| DUSP16 | S501 | |||||
| PPM1G | S527 | |||||
| PTPN1 | S352 | |||||
| PTPN12 | S435;S449 | T578;S689;T693 | ||||
| PTPN14 | S461;S465;S486 | |||||
| SSH3 | S37 | |||||
| TENC1 | S102;S105 | |||||
| Gene name . | Regulation profile . | |||||
|---|---|---|---|---|---|---|
| Cluster 1 . | Cluster 2 . | Cluster 3 . | Cluster 4 . | Cluster 5 . | Cluster 6 . | |
| Tyrosine kinases | ||||||
| ABL2 | S783;S817;S820 | T818 | ||||
| EPHA2 | S579 | S897;T898;S901 | ||||
| FYN | S21 | |||||
| KDR | S1227 | S1235;T1238 | ||||
| PEAK1 | S902 | S826 | T852;S854 | S854;S1214;S1217;S1250 | ||
| SGK223 | S694 | T1223 | ||||
| Serine/threonine kinases | ||||||
| AAK1 | S637 | S846 | ||||
| ACVRL1 | S155 | S160 | ||||
| ADRBK1 | S670 | |||||
| AKT3 | S472;S476 | |||||
| CAMK2D | S315;S318;S319 | S330;T337 | ||||
| CAMK2G | S315;S319 | |||||
| CDC42BPA | S1545 | |||||
| CDC42BPB | S1693 | |||||
| CDK13 | T1056;T1058 | |||||
| CDK14 | S95 | |||||
| CDK17 | S75;S92;S137;S176;S180 | |||||
| DAPK3 | T306 | |||||
| EIF2AK3 | S715;S719 | |||||
| GSK3B | T390 | |||||
| ILK | T172;T173 | |||||
| KSR1 | T268;T272;S332 | |||||
| LATS1 | S464 | |||||
| LIMK2 | S293;S298 | |||||
| MAP2K2 | S293;S295 | |||||
| MAP2K7 | S55;S61 | |||||
| MAP3K11 | T702;S705;T708 | S789;S793 | ||||
| MAP3K3 | S337;S340 | S340 | ||||
| MAP4K4 | S900 | S602 | ||||
| MAP4K5 | S433 | |||||
| MAPK1 | T185;Y187 | T185;Y187 | ||||
| MAPK3 | Y204 | T202;Y204 | ||||
| MAPK14 | T180;Y182 | Y182 | ||||
| MARK2 | S40;S631 | S390 | ||||
| MARK3 | S391 | |||||
| MAST2 | S876;S1256 | S1264 | S209 | |||
| MAST4 | S2523 | S261;S917;S1286;S1373;T1393;S1470;S1526;S2445 | S266;S1373;S1380;S1782 | S1950 | ||
| MINK1 | S778;S782 | |||||
| MLTK | S648 | S633 | ||||
| NRBP1 | T232 | S2 | ||||
| PAK2 | S197 | S55 | ||||
| PRKAA1 | S486;T490;S527 | |||||
| PRKCD | S304 | |||||
| PRKD1 | S237;S549;S742^ | S205;S208;S219;S249; S397^;S401^ | ||||
| PRKD2 | S203;S518 | S375;S710;S876 | S197;S214 | S198 | ||
| PRKD3 | S213;S216;S735^ | S391^;S395^ | ||||
| PRPF4B | S578;S580 | |||||
| PTK2 | Y861 | |||||
| RIPK1 | S320 | S320;S330 | ||||
| RIPK2 | S178 | S531 | S363 | |||
| RIPK3 | S410 | |||||
| ROCK2 | S1374 | |||||
| RPS6KA3 | T365;S369 | S715 | ||||
| RPS6KB1 | S441;T444;S447 | S427 | ||||
| SLK | S779 | |||||
| STK10 | S13;T14 | S514 | T952 | S417 | ||
| STK17A | S28 | |||||
| STK24 | S4 | |||||
| STRADA | S46 | |||||
| TAOK1 | S9 | |||||
| TAOK2 | S9 | |||||
| TAOK3 | S324 | S331 | ||||
| TNIK | S640;S678;S680 | |||||
| TRIO | S1785;S1786 | S2477 | S2455;S2459 | |||
| WNK1 | S167;S2372 | S174 | ||||
| Phosphatases | ||||||
| CTDSPL2 | S104 | |||||
| DUSP6 | S351 | |||||
| DUSP16 | S501 | |||||
| PPM1G | S527 | |||||
| PTPN1 | S352 | |||||
| PTPN12 | S435;S449 | T578;S689;T693 | ||||
| PTPN14 | S461;S465;S486 | |||||
| SSH3 | S37 | |||||
| TENC1 | S102;S105 | |||||
The reported amino acid position refers to the protein, within the protein group, for which a reference number (referred to as UniProtKB) was found in the PhosphoSitePlus database.
Bold, functional phosphosite (according to PhosphoSitePlus); ^, redundant site.