Table 3 Genetic aberrations reported to... | American Society of Hematology

Table 3

Genetic aberrations reported to be associated with iMCD and iMCD-like diseases

Citation	Gene	Key findings
Nakamura et al 1993²⁷	IL-6 (presumed by authors)	Somatic translocation [46,XY,t(7;14)(p22;q22)] at the IL-6 gene locus (7p21-22) in lymph node cells in 1 case report
Gleason et al 2008⁴⁹	ALK	Somatic ALK-mutated tumors secrete cytokines and cause MCD-like features
Kone-Paut et al 2009⁷³	MEFV	Heterozygous for a germ-line MEFV gene mutation in one CD case
Stone et al 2013³⁷	IL-6 receptor	SNP present in 49% of 58 iMCD cases vs 33% of 50 controls (P = .0175)

Citation	Gene	Key findings
Nakamura et al 1993²⁷	IL-6 (presumed by authors)	Somatic translocation [46,XY,t(7;14)(p22;q22)] at the IL-6 gene locus (7p21-22) in lymph node cells in 1 case report
Gleason et al 2008⁴⁹	ALK	Somatic ALK-mutated tumors secrete cytokines and cause MCD-like features
Kone-Paut et al 2009⁷³	MEFV	Heterozygous for a germ-line MEFV gene mutation in one CD case
Stone et al 2013³⁷	IL-6 receptor	SNP present in 49% of 58 iMCD cases vs 33% of 50 controls (P = .0175)