In vivo paired recoveries and survivals of autologous radiolabeled Haemonetics, Spectra, and Trima apheresis platelets
| N . | Control platelets . | Test PAS platelets . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Storage solution . | Storage time (days) . | Platelet . | Storage time (days) . | Platelet . | |||||
| Recoveries (%) . | Survivals (days) . | Recoveries (%) . | Percent of control . | Survivals (days) . | Percent of control . | ||||
| Haemonetics apheresis platelets | |||||||||
| 6 | Plasma | 5 | 59 ± 7 | 6.5 ± 0.6 | 5 | 59 ± 5 | 102 ± 6 | 6.3 ± 0.8 | 100 ± 13 |
| 10 | Plasma | 7 | 44 ± 5 | 4.9 ± 0.7 | 7 | 52 ± 3a | 130 ± 12 | 6.0 ± 0.3 | 171 ± 49 |
| 4 | Plasma | 1 | 67 ± 4 | 7.6 ± 1.1 | 9 | 55 ± 5 | 82 ± 10 | 6.6 ± 0.6 | 93 ± 19 |
| 10 | Plasma | 1 | 67 ± 4 | 7.0 ± 0.6 | 13 | 49 ± 3a | 73 ± 4 | 4.6 ± 0.3a | 69 ± 6 |
| 10 | Plasma | 1 | 65 ± 4 | 7.4 ± 0.6 | 14 | 43 ± 3a | 67 ± 4 | 4.2 ± 0.5a | 57 ± 6 |
| 3 | None | Fresh | 64 ± 9 | 8.2 ± 1.3 | 15 | 57 ± 3 | 95 ± 14 | 3.4 ± 0.3a | 50 ± 5 |
| 7 | None | Fresh | 48 ± 6 | 8.5 ± 0.3 | 15b | 24 ± 3a | 55 ± 8 | 2.2 ± 0.2a | 26 ± 2 |
| 3 | None | Fresh | 68 ± 4 | 6.1 ± 0.7 | 17 | 37 ± 3c | 55 ± 5 | 3.1 ± 0.6a | 50 ± 5 |
| 3 | None | Fresh | 69 ± 3 | 7.8 ± 0.9 | 18 | 43 ± 2a | 62 ± 2 | 3.6 ± 1.0c | 46 ± 10 |
| Spectra apheresis platelets | |||||||||
| 3 | PAS | 1 | 61 ± 6 | 7.3 ± 1.5 | 7 | 49 ± 6a | 77 ± 4 | 5.0 ± 0.3 | 66 ± 3 |
| 5 | PAS | 5 | 67 ± 4 | 6.6 ± 0.5 | 7 | 60 ± 2 | 91 ± 4 | 5.3 ± 0.5c | 81 ± 5 |
| 7 | Plasma | 7 | 52 ± 4 | 4.8 ± 0.3 | 7d | 37 ± 8c | 68 ± 13 | 3.2 ± 0.5 | 71 ± 16 |
| 5 | Plasma | 5 | 55 ± 6 | 6.7 ± 0.9 | 8e | 45 ± 8c | 80 ± 8 | 4.0 ± 0.8c | 60 ± 12 |
| 5 | Plasma | 5 | 50 ± 5 | 6.0 ± 0.1 | 9f | 24 ± 6c | 49 ± 13 | 3.2 ± 1.1c | 52 ± 18 |
| 5g | PAS | 13 | 40 ± 5 | 2.2 ± 0.5 | 13h | 41 ± 7 | 110 ± 20 | 4.9 ± 0.8 | 320 ± 109 |
| Trima apheresis platelets | |||||||||
| 9 | None | Fresh | 58 ± 5 | 8.3 ± 0.2 | 7 | 44 ± 3a | 77 ± 4 | 5.4 ± 0.3 | 66 ± 3 |
| 8 | None | Fresh | 54 ± 4 | 7.7 ± 0.4 | 9i | 29 ± 7a | 54 ± 12 | 3.4 ± 0.6a | 46 ± 8 |
| 10 | None | Fresh | 57 ± 4 | 8.5 ± 0.2 | 9h | 44 ± 4a | 78 ± 5 | 5.0 ± 0.2a | 59 ± 2 |
| 2 | None | Fresh | 64, 35 | 8.4, 7.5 | 13j | 3, 17 | 5, 49 | 0.6, 2.3 | 7, 13 |
| N . | Control platelets . | Test PAS platelets . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Storage solution . | Storage time (days) . | Platelet . | Storage time (days) . | Platelet . | |||||
| Recoveries (%) . | Survivals (days) . | Recoveries (%) . | Percent of control . | Survivals (days) . | Percent of control . | ||||
| Haemonetics apheresis platelets | |||||||||
| 6 | Plasma | 5 | 59 ± 7 | 6.5 ± 0.6 | 5 | 59 ± 5 | 102 ± 6 | 6.3 ± 0.8 | 100 ± 13 |
| 10 | Plasma | 7 | 44 ± 5 | 4.9 ± 0.7 | 7 | 52 ± 3a | 130 ± 12 | 6.0 ± 0.3 | 171 ± 49 |
| 4 | Plasma | 1 | 67 ± 4 | 7.6 ± 1.1 | 9 | 55 ± 5 | 82 ± 10 | 6.6 ± 0.6 | 93 ± 19 |
| 10 | Plasma | 1 | 67 ± 4 | 7.0 ± 0.6 | 13 | 49 ± 3a | 73 ± 4 | 4.6 ± 0.3a | 69 ± 6 |
| 10 | Plasma | 1 | 65 ± 4 | 7.4 ± 0.6 | 14 | 43 ± 3a | 67 ± 4 | 4.2 ± 0.5a | 57 ± 6 |
| 3 | None | Fresh | 64 ± 9 | 8.2 ± 1.3 | 15 | 57 ± 3 | 95 ± 14 | 3.4 ± 0.3a | 50 ± 5 |
| 7 | None | Fresh | 48 ± 6 | 8.5 ± 0.3 | 15b | 24 ± 3a | 55 ± 8 | 2.2 ± 0.2a | 26 ± 2 |
| 3 | None | Fresh | 68 ± 4 | 6.1 ± 0.7 | 17 | 37 ± 3c | 55 ± 5 | 3.1 ± 0.6a | 50 ± 5 |
| 3 | None | Fresh | 69 ± 3 | 7.8 ± 0.9 | 18 | 43 ± 2a | 62 ± 2 | 3.6 ± 1.0c | 46 ± 10 |
| Spectra apheresis platelets | |||||||||
| 3 | PAS | 1 | 61 ± 6 | 7.3 ± 1.5 | 7 | 49 ± 6a | 77 ± 4 | 5.0 ± 0.3 | 66 ± 3 |
| 5 | PAS | 5 | 67 ± 4 | 6.6 ± 0.5 | 7 | 60 ± 2 | 91 ± 4 | 5.3 ± 0.5c | 81 ± 5 |
| 7 | Plasma | 7 | 52 ± 4 | 4.8 ± 0.3 | 7d | 37 ± 8c | 68 ± 13 | 3.2 ± 0.5 | 71 ± 16 |
| 5 | Plasma | 5 | 55 ± 6 | 6.7 ± 0.9 | 8e | 45 ± 8c | 80 ± 8 | 4.0 ± 0.8c | 60 ± 12 |
| 5 | Plasma | 5 | 50 ± 5 | 6.0 ± 0.1 | 9f | 24 ± 6c | 49 ± 13 | 3.2 ± 1.1c | 52 ± 18 |
| 5g | PAS | 13 | 40 ± 5 | 2.2 ± 0.5 | 13h | 41 ± 7 | 110 ± 20 | 4.9 ± 0.8 | 320 ± 109 |
| Trima apheresis platelets | |||||||||
| 9 | None | Fresh | 58 ± 5 | 8.3 ± 0.2 | 7 | 44 ± 3a | 77 ± 4 | 5.4 ± 0.3 | 66 ± 3 |
| 8 | None | Fresh | 54 ± 4 | 7.7 ± 0.4 | 9i | 29 ± 7a | 54 ± 12 | 3.4 ± 0.6a | 46 ± 8 |
| 10 | None | Fresh | 57 ± 4 | 8.5 ± 0.2 | 9h | 44 ± 4a | 78 ± 5 | 5.0 ± 0.2a | 59 ± 2 |
| 2 | None | Fresh | 64, 35 | 8.4, 7.5 | 13j | 3, 17 | 5, 49 | 0.6, 2.3 | 7, 13 |
Fresh platelets were prepared from a blood sample drawn from the donor on the day the stored platelets were injected. Percent of control results were determined by dividing the test results by the control × 100. Data are given as the average ± 1 standard error.
P < .01. P values for PAS platelet recoveries and survivals are based on the differences between the PAS data and the control platelet data for each study.
These platelets were stored in Haemonetics CPP bags vs all other Haemonetics collection studies that were stored in Haemonetics CLX bags.
P < .05. P values for PAS platelet recoveries and survivals are based on the differences between the PAS data and the control platelet data for each study.
Four units had poststorage pHs of ≤6.0 with platelet recoveries of 57%, 18%, 17%, and 9% and associated survivals of 1.7, 2.3, 2.2, and 2.9 days, respectively.
One unit had poststorage pH of 6.3 and platelet recovery of 24% and survival of 2.6 days.
Three units had poststorage pHs of 6.4, 6.3, and 5.7 with associated platelet recoveries of 8%, 13%, and 28% and survivals of 1.6, 1.7, and 1.1 days, respectively.
One collection not injected as pH <6.0 for both bags at the end of storage.
These Terumo BCT platelets were stored in Haemonetics CLX rather than Terumo BCT bags.
One unit not injected as poststorage pH <6.0. Two other units both had poststorage pHs of 6.1 and recoveries of 2% and 3% and survivals of 1.7 and 0.5 days, respectively.
One unit with post-storage pH of 6.4 had a platelet recovery of 3% and platelet survival of 0.6 days.