Table 1 Paraneoplastic neurological... | American Society of Hematology

Table 1

Paraneoplastic neurological syndromes

Syndrome	Associated antibodies	Predominant lymphoma type	Selected references
LE	mGluR5	HL	16
Granulomatous angiitis	None	HL	40, 41
Cerebellar degeneration	Tr (DNER)	HL	5, 6
Paraneoplastic chorea	CV2/CRMP5*	<10 cases (NHL in 4)	57, 58
Opsoclonus-myoclonus	None	<10 cases (NHL in 3)	64, 66
Stiff-person syndrome	None	HL	67, 72
Paraneoplastic myelopathy	None	HL and NHL	73, 74
Motor neuronopathy	None	HL	79, 80
Sensory neuronopathy	None†	<10 cases (5 with HL)	81, 82
Autonomic ganglionopathy	nAChR‡	<10 cases (HL, NHL)	87, 88
Sensorimotor neuropathy	None	HL and NHL	94
Vasculitic neuropathy	None	NHL	97
Neuromyotonia	None	<10 cases (HL, NHL)	104
Lambert-Eaton myasthenic syndrome	VGCC‡	<10 cases (NHL)	102
Myasthenia	AChR‡	HL and NHL	105
Dermatomyositis	p155	NHL	99

Syndrome	Associated antibodies	Predominant lymphoma type	Selected references
LE	mGluR5	HL	16
Granulomatous angiitis	None	HL	40, 41
Cerebellar degeneration	Tr (DNER)	HL	5, 6
Paraneoplastic chorea	CV2/CRMP5*	<10 cases (NHL in 4)	57, 58
Opsoclonus-myoclonus	None	<10 cases (NHL in 3)	64, 66
Stiff-person syndrome	None	HL	67, 72
Paraneoplastic myelopathy	None	HL and NHL	73, 74
Motor neuronopathy	None	HL	79, 80
Sensory neuronopathy	None†	<10 cases (5 with HL)	81, 82
Autonomic ganglionopathy	nAChR‡	<10 cases (HL, NHL)	87, 88
Sensorimotor neuropathy	None	HL and NHL	94
Vasculitic neuropathy	None	NHL	97
Neuromyotonia	None	<10 cases (HL, NHL)	104
Lambert-Eaton myasthenic syndrome	VGCC‡	<10 cases (NHL)	102
Myasthenia	AChR‡	HL and NHL	105
Dermatomyositis	p155	NHL	99

Classical syndromes are underlined. nAChR, nicotinic acetylcholine receptor; VGCC, voltage-gated calcium channel.

Not present in all cases.

One patient with NHL and Ma2 antibodies (not published).

Marker of the syndrome, not predictor of cancer.