Table 1 Somatic mutations in the C... | American Society of Hematology

Table 1

Somatic mutations in the C terminus of CXCR4 identified by Sanger sequencing and stratified by MYD88 L265P mutation status in WM patients

n	MYD88 status	Mutation type	Nucleotide change	Amino acid change
1	L265P	NS	r.997 A>T*	K333X*
3	L265P	NS	r.1000C>T	R334X
7	L265P	NS	r.1013C>A	S338X
15	L265P	NS	r.1013C>G†	S338X†
1	WT	FS	r.931_933insT	T311fs
3	L265P	FS	r.952_954insA	T318fs
2	L265P	FS	r.951_953delACCTC	T318fs
1	L265P	FS	r.954_956insC	S319fs
1	L265P	FS	r.958_960delTG	V320fs
1	L265P	FS	r.963_965insC	R322fs
1	L265P	FS	r.969_971insG	S324fs
1	L265P	FS	r.978_980insT	K327fs
1	L265P	FS	r.984_986insT	L329fs
1	L265P	FS	r.993_995insA	G332fs
1	L265P	FS	r.1005_1007insT	G336fs
2	L265P	FS	r.1013_1015delATCT	S338fs
1	L265P	FS	r.1013_1015delATCTGTTTCCACTGAGT	S338fs
3	L265P	FS	r.1012_1014insT	S338fs
1	L265P	FS	r.1015_1017delCT	S339fs
1	L265P	FS	r.1020_1022delT	S341fs
1	L265P	FS	r.1024_1026delCT	S342fs
1	L265P	FS	r.1030_1041CTGAGTCTTC>GT	S344fs
1	L265P	FS	r.1033_1035delAG	E345fs

n	MYD88 status	Mutation type	Nucleotide change	Amino acid change
1	L265P	NS	r.997 A>T*	K333X*
3	L265P	NS	r.1000C>T	R334X
7	L265P	NS	r.1013C>A	S338X
15	L265P	NS	r.1013C>G†	S338X†
1	WT	FS	r.931_933insT	T311fs
3	L265P	FS	r.952_954insA	T318fs
2	L265P	FS	r.951_953delACCTC	T318fs
1	L265P	FS	r.954_956insC	S319fs
1	L265P	FS	r.958_960delTG	V320fs
1	L265P	FS	r.963_965insC	R322fs
1	L265P	FS	r.969_971insG	S324fs
1	L265P	FS	r.978_980insT	K327fs
1	L265P	FS	r.984_986insT	L329fs
1	L265P	FS	r.993_995insA	G332fs
1	L265P	FS	r.1005_1007insT	G336fs
2	L265P	FS	r.1013_1015delATCT	S338fs
1	L265P	FS	r.1013_1015delATCTGTTTCCACTGAGT	S338fs
3	L265P	FS	r.1012_1014insT	S338fs
1	L265P	FS	r.1015_1017delCT	S339fs
1	L265P	FS	r.1020_1022delT	S341fs
1	L265P	FS	r.1024_1026delCT	S342fs
1	L265P	FS	r.1030_1041CTGAGTCTTC>GT	S344fs
1	L265P	FS	r.1033_1035delAG	E345fs

Patient also had subclonal population with 1013C>G (S338X) NS mutation.

One patient had subclonal population with 993_995insA (G332fs) FS mutation.