Outcomes of new pregnancies in APS women and in control women with prior fetal loss
| . | APS, 311 . | Control, 313 . | . | . | ||
|---|---|---|---|---|---|---|
| Group, N . | N . | Incidence . | N . | Incidence . | RR, 95% CI . | P . |
| New pregnancies | 308 | 0.990 | 311 | 0.994 | ||
| Spontaneous abortions before 10 WG | 53 | 0.172 | 83 | 0.267 | 0.679 (0.503-0.917) | .0116 |
| Ongoing pregnancies at 10 WG | 255 | 0.828 | 230 | 0.740 | 1.116 (1.025-1.214) | .0110 |
| Fetal losses (% of new pregnancies) | 49 | 0.159 | 72 | 0.232 | 0.685 (0.494-0.950) | .0234 |
| Fetal losses (% of ongoing pregnancies at 10 WG) | 49 | 0.192 | 72 | 0.313 | 0.614 (0.447-0.842) | .0025 |
| Ongoing pregnancy at 20 WG (% of new pregnancies) | 226 | 0.734 | 180 | 0.579 | 1.264 (1.124-1.421) | .0001 |
| Live births (% of new pregnancies) | 206 | 0.669 | 158 | 0.508 | 1.312 (1.146-1.503) | .0001 |
| Live births (% of ongoing pregnancies at 10 WG) | 206 | 0.808 | 158 | 0.687 | 1.176 (1.058-1.307) | .0027 |
| Preterm live births <37 WG (% of live births) | 68 | 0.330 | 39 | 0.247 | 1.337 (0.957-1.869) | .0887 |
| Preterm live births <34 WG (% of live births) | 35 | 0.170 | 19 | 0.120 | 1.413 (0.841-2.373) | .192 |
| PE (% of ongoing pregnancies at 20 WG) | 45 | 0.199 | 21 | 0.117 | 1.707 (1.057-2.757) | .0289 |
| Severe PE | 32 | 0.142 | 15 | 0.083 | 1.614 (0.904-2.884) | .106 |
| PE <34 WG | 28 | 0.124 | 11 | 0.061 | 2.028 (1.038-3.960) | .0385 |
| Eclampsia | 10 | 0.044 | 5 | 0.028 | 1.593 (0.554-4.577) | .387 |
| HELLP syndrome | 13 | 0.058 | 4 | 0.022 | 2.589 (0.859-7.803) | .0911 |
| SGA (% of ongoing pregnancies at 20 WG) | 46 | 0.204 | 37 | 0.206 | 0.990 (0.673-1.457) | .960 |
| Severe SGA <p5 | 24 | 0.106 | 19 | 0.106 | 1.006 (0.569-1.777) | .983 |
| Very severe SGA <p3 | 17 | 0.075 | 12 | 0.067 | 1.128 (0.553-2.301) | .740 |
| PE + SGA | 30 | 0.133 | 13 | 0.072 | 1.838 (0.988-3.419) | .0546 |
| PA (% of ongoing pregnancies at 20 WG) | 8 | 0.035 | 6 | 0.033 | 1.062 (0.375-3.005) | .910 |
| Placenta-mediated complications: PE and/or SGA and/or PA (% of ongoing pregnancies at 20 WG) | 65 | 0.288 | 50 | 0.278 | 1.035 (0.758-1.415) | .827 |
| NM (% of live births) | 12 | 0.058 | 4 | 0.025 | 2.301 (0.756-6.999) | .142 |
| Early NM, day 1-7 | 5 | 0.024 | 3 | 0.019 | 1.278 (0.310-5.269) | .734 |
| Late NM, day 8-27 | 7 | 0.034 | 1 | 0.006 | 5.369 (0.667-43.19) | .114 |
| . | APS, 311 . | Control, 313 . | . | . | ||
|---|---|---|---|---|---|---|
| Group, N . | N . | Incidence . | N . | Incidence . | RR, 95% CI . | P . |
| New pregnancies | 308 | 0.990 | 311 | 0.994 | ||
| Spontaneous abortions before 10 WG | 53 | 0.172 | 83 | 0.267 | 0.679 (0.503-0.917) | .0116 |
| Ongoing pregnancies at 10 WG | 255 | 0.828 | 230 | 0.740 | 1.116 (1.025-1.214) | .0110 |
| Fetal losses (% of new pregnancies) | 49 | 0.159 | 72 | 0.232 | 0.685 (0.494-0.950) | .0234 |
| Fetal losses (% of ongoing pregnancies at 10 WG) | 49 | 0.192 | 72 | 0.313 | 0.614 (0.447-0.842) | .0025 |
| Ongoing pregnancy at 20 WG (% of new pregnancies) | 226 | 0.734 | 180 | 0.579 | 1.264 (1.124-1.421) | .0001 |
| Live births (% of new pregnancies) | 206 | 0.669 | 158 | 0.508 | 1.312 (1.146-1.503) | .0001 |
| Live births (% of ongoing pregnancies at 10 WG) | 206 | 0.808 | 158 | 0.687 | 1.176 (1.058-1.307) | .0027 |
| Preterm live births <37 WG (% of live births) | 68 | 0.330 | 39 | 0.247 | 1.337 (0.957-1.869) | .0887 |
| Preterm live births <34 WG (% of live births) | 35 | 0.170 | 19 | 0.120 | 1.413 (0.841-2.373) | .192 |
| PE (% of ongoing pregnancies at 20 WG) | 45 | 0.199 | 21 | 0.117 | 1.707 (1.057-2.757) | .0289 |
| Severe PE | 32 | 0.142 | 15 | 0.083 | 1.614 (0.904-2.884) | .106 |
| PE <34 WG | 28 | 0.124 | 11 | 0.061 | 2.028 (1.038-3.960) | .0385 |
| Eclampsia | 10 | 0.044 | 5 | 0.028 | 1.593 (0.554-4.577) | .387 |
| HELLP syndrome | 13 | 0.058 | 4 | 0.022 | 2.589 (0.859-7.803) | .0911 |
| SGA (% of ongoing pregnancies at 20 WG) | 46 | 0.204 | 37 | 0.206 | 0.990 (0.673-1.457) | .960 |
| Severe SGA <p5 | 24 | 0.106 | 19 | 0.106 | 1.006 (0.569-1.777) | .983 |
| Very severe SGA <p3 | 17 | 0.075 | 12 | 0.067 | 1.128 (0.553-2.301) | .740 |
| PE + SGA | 30 | 0.133 | 13 | 0.072 | 1.838 (0.988-3.419) | .0546 |
| PA (% of ongoing pregnancies at 20 WG) | 8 | 0.035 | 6 | 0.033 | 1.062 (0.375-3.005) | .910 |
| Placenta-mediated complications: PE and/or SGA and/or PA (% of ongoing pregnancies at 20 WG) | 65 | 0.288 | 50 | 0.278 | 1.035 (0.758-1.415) | .827 |
| NM (% of live births) | 12 | 0.058 | 4 | 0.025 | 2.301 (0.756-6.999) | .142 |
| Early NM, day 1-7 | 5 | 0.024 | 3 | 0.019 | 1.278 (0.310-5.269) | .734 |
| Late NM, day 8-27 | 7 | 0.034 | 1 | 0.006 | 5.369 (0.667-43.19) | .114 |
95% CI, 95% confidence interval; NM, neonatal mortality; PA, placental abruption; RR, relative risk, APS women vs control women.