Outcomes of new pregnancies in women from the thrombophilia group and no-thrombophilia group with prior recurrent abortions
| . | Thrombophilia, 93 . | . | No-thrombophilia, 483 . | . | . | . |
|---|---|---|---|---|---|---|
| Group, N . | n/N . | Incidence . | n/N . | Incidence . | RR (95% CI)* . | P . |
| New pregnancies | 93/93 | 1.000 | 480/483 | 0.994 | ||
| Prophylactic LMWH treatment during pregnancy | 0/93 | 0 | 0/480 | 0 | ||
| Spontaneous abortions before 10 WG | 13/93 | 0.140 | 92/480 | 0.192 | 0.734 (0.429-1.255) | .2584 |
| Ongoing pregnancies at 10 WG | 80/93 | 0.860 | 388/480 | 0.808 | 1.063 (0,969-1.1656) | .1988 |
| Fetal deaths (% of new pregnancies) | 7/93 | 0.075 | 9/480 | 0.019 | 4.039 (1.543-10.58) | .0045 |
| Fetal deaths (% of ongoing pregnancies at 10 WG) | 7/80 | 0.088 | 9/388 | 0.023 | 3.801 (1.458-9.908) | .0063 |
| Ongoing pregnancy at 20 WG (% of new pregnancies) | 75/93 | 0.806 | 384/480 | 0.800 | 1.007 (0.903-1.122) | .9073 |
| Live births (% of new pregnancies) | 73/93 | 0.774 | 379/480 | 0.790 | 1.027 (0.912-1.156) | .6639 |
| Live births (% of ongoing pregnancies at 10 WG) | 73/80 | 0.913 | 379/388 | 0.977 | 0.934 [0.871-1.001) | .0543 |
| Preterm live births <37 WG (% of live births) | 12/73 | 0.164 | 35/379 | 0.092 | 1.794 (0.979-3.289) | .0587 |
| Preterm live births <34 WG (% of live births) | 5/73 | 0.068 | 13/379 | 0.034 | 2.013 (0.740-5.474) | .1706 |
| PE (% of ongoing pregnancies at 20 WG) | 5/75 | 0.066 | 11/384 | 0.029 | 2.346 (0.839-6.555) | .1040 |
| Severe PE | 2/75 | 0.027 | 6/384 | 0.016 | 1.720 (0.354-8.360) | .5014 |
| PE <34 WG | 3/75 | 0.040 | 4/384 | 0.010 | 3.870 (0.884-16.94) | .0724 |
| Eclampsia | 1/75 | 0.013 | 3/384 | 0.008 | 1.720 (0.181-16.31) | .6366 |
| HELLP syndrome | 1/75 | 0.013 | 2/384 | 0.005 | 2.580 (0.237-28.09) | .4366 |
| SGA (% of ongoing pregnancies at 20 WG) | 11/75 | 0.147 | 43/384 | 0.112 | 1.320 (0.714-2.440) | .3758 |
| Severe SGA <p5 | 6/75 | 0.080 | 21/384 | 0.055 | 1.474 (0.616-3.529) | .3835 |
| Very severe SGA <p3 | 4/75 | 0.053 | 13/384 | 0.034 | 1.588 (0.532-4.737) | .4071 |
| PE+SGA | 3/75 | 0.040 | 7/384 | 0.018 | 2.211 (0.585-8.359) | .2421 |
| PA (% of ongoing pregnancies at 20 WG) | 2/75 | 0.027 | 5/384 | 0.013 | 2.064 (0.408-10.44) | .3810 |
| Placenta-mediated complications: PE and/or SGA and/or PA (% of ongoing pregnancies at 20 WG) | 14/75 | 0.187 | 49/384 | 0.128 | 1.474 (0.859-2.530) | .1589 |
| NM (% of live births) | 2/73 | 0.027 | 4/379 | 0.011 | 2.618 (0.488-14.02) | .2615 |
| Early NM, day 1-d 7 | 2/73 | 0.027 | 2/379 | 0.005 | 5.233 (0.749-36.56) | .0952 |
| Late NM, day 8-d 27 | 0/73 | 0 | 2/379 | 0.005 | 1.0351 (0.050-21.34) | .9822 |
| . | Thrombophilia, 93 . | . | No-thrombophilia, 483 . | . | . | . |
|---|---|---|---|---|---|---|
| Group, N . | n/N . | Incidence . | n/N . | Incidence . | RR (95% CI)* . | P . |
| New pregnancies | 93/93 | 1.000 | 480/483 | 0.994 | ||
| Prophylactic LMWH treatment during pregnancy | 0/93 | 0 | 0/480 | 0 | ||
| Spontaneous abortions before 10 WG | 13/93 | 0.140 | 92/480 | 0.192 | 0.734 (0.429-1.255) | .2584 |
| Ongoing pregnancies at 10 WG | 80/93 | 0.860 | 388/480 | 0.808 | 1.063 (0,969-1.1656) | .1988 |
| Fetal deaths (% of new pregnancies) | 7/93 | 0.075 | 9/480 | 0.019 | 4.039 (1.543-10.58) | .0045 |
| Fetal deaths (% of ongoing pregnancies at 10 WG) | 7/80 | 0.088 | 9/388 | 0.023 | 3.801 (1.458-9.908) | .0063 |
| Ongoing pregnancy at 20 WG (% of new pregnancies) | 75/93 | 0.806 | 384/480 | 0.800 | 1.007 (0.903-1.122) | .9073 |
| Live births (% of new pregnancies) | 73/93 | 0.774 | 379/480 | 0.790 | 1.027 (0.912-1.156) | .6639 |
| Live births (% of ongoing pregnancies at 10 WG) | 73/80 | 0.913 | 379/388 | 0.977 | 0.934 [0.871-1.001) | .0543 |
| Preterm live births <37 WG (% of live births) | 12/73 | 0.164 | 35/379 | 0.092 | 1.794 (0.979-3.289) | .0587 |
| Preterm live births <34 WG (% of live births) | 5/73 | 0.068 | 13/379 | 0.034 | 2.013 (0.740-5.474) | .1706 |
| PE (% of ongoing pregnancies at 20 WG) | 5/75 | 0.066 | 11/384 | 0.029 | 2.346 (0.839-6.555) | .1040 |
| Severe PE | 2/75 | 0.027 | 6/384 | 0.016 | 1.720 (0.354-8.360) | .5014 |
| PE <34 WG | 3/75 | 0.040 | 4/384 | 0.010 | 3.870 (0.884-16.94) | .0724 |
| Eclampsia | 1/75 | 0.013 | 3/384 | 0.008 | 1.720 (0.181-16.31) | .6366 |
| HELLP syndrome | 1/75 | 0.013 | 2/384 | 0.005 | 2.580 (0.237-28.09) | .4366 |
| SGA (% of ongoing pregnancies at 20 WG) | 11/75 | 0.147 | 43/384 | 0.112 | 1.320 (0.714-2.440) | .3758 |
| Severe SGA <p5 | 6/75 | 0.080 | 21/384 | 0.055 | 1.474 (0.616-3.529) | .3835 |
| Very severe SGA <p3 | 4/75 | 0.053 | 13/384 | 0.034 | 1.588 (0.532-4.737) | .4071 |
| PE+SGA | 3/75 | 0.040 | 7/384 | 0.018 | 2.211 (0.585-8.359) | .2421 |
| PA (% of ongoing pregnancies at 20 WG) | 2/75 | 0.027 | 5/384 | 0.013 | 2.064 (0.408-10.44) | .3810 |
| Placenta-mediated complications: PE and/or SGA and/or PA (% of ongoing pregnancies at 20 WG) | 14/75 | 0.187 | 49/384 | 0.128 | 1.474 (0.859-2.530) | .1589 |
| NM (% of live births) | 2/73 | 0.027 | 4/379 | 0.011 | 2.618 (0.488-14.02) | .2615 |
| Early NM, day 1-d 7 | 2/73 | 0.027 | 2/379 | 0.005 | 5.233 (0.749-36.56) | .0952 |
| Late NM, day 8-d 27 | 0/73 | 0 | 2/379 | 0.005 | 1.0351 (0.050-21.34) | .9822 |
Thrombophilic vs nonthrombophilic women.