| Characteristics . | All-cause mortality . | DLBCL-specific mortality . | ||
|---|---|---|---|---|
| No. of deaths . | HR (95% CI) . | No. of deaths . | HR (95% CI) . | |
| Age at diagnosis | 1.04 (1.04-1.04) | 1.03 (1.03-1.03) | ||
| Race/ethnicity | ||||
| Non-Hispanic white | 14 148 | 1.00 (Reference) | 9 008 | 1.00 (Reference) |
| African American | 787 | 1.00 (0.93-1.08) | 489 | 0.94 (0.86-1.03) |
| Hispanic | 3 405 | 1.04 (1.00-1.08) | 2 193 | 1.02 (0.97-1.07) |
| Asian/Pacific Islander | 1 979 | 1.03 (0.98-1.08) | 1 338 | 1.08 (1.02-1.15) |
| Sex | ||||
| Male | 10 819 | 1.00 (Reference) | 6 792 | 1.00 (Reference) |
| Female | 9 500 | 0.82 (0.79-0.84) | 6 236 | 0.90 (0.87-0.94) |
| Marital status at diagnosis | ||||
| Married | 11 222 | 1.00 (Reference) | 7 278 | 1.00 (Reference) |
| Never married | 2 482 | 1.22 (1.16-1.27) | 1 611 | 1.13 (1.07-1.20) |
| Previously married | 6 061 | 1.19 (1.15-1.23) | 3 804 | 1.13 (1.09-1.18) |
| Unknown | 554 | 0.97 (0.89-1.06) | 335 | 0.91 (0.81-1.01) |
| Period of diagnosis | ||||
| 1988-2000 | 12 832 | 1.00 (Reference) | 7 838 | 1.00 (Reference) |
| 2001-2009 | 7 487 | 0.71 (0.68-0.73) | 5 190 | 0.69 (0.67-0.72) |
| B symptoms | ||||
| Absent | 7 090 | 1.00 (Reference) | 4 427 | 1.00 (Reference) |
| Present | 4 832 | 1.33 (1.28-1.38) | 3 511 | 1.45 (1.38-1.52) |
| Unknown | 8 397 | 1.12 (1.09-1.16) | 5 090 | 1.14 (1.09-1.19) |
| Nodal status | ||||
| Nodal | 13 638 | 1.00 (Reference) | 9 110 | 1.00 (Reference) |
| Extranodal | 6 681 | 1.01 (0.98-1.04) | 3 918 | 0.97 (0.93-1.01) |
| Chemotherapy | ||||
| No | 5 815 | 1.00 (Reference) | 3 461 | 1.00 (Reference) |
| Yes | 14 117 | 0.52 (0.50-0.54) | 9 339 | 0.53 (0.51-0.55) |
| Unknown | 387 | 0.52 (0.47-0.58) | 228 | 0.52 (0.45-0.59) |
| Radiation | ||||
| No | 15 742 | 1.00 (Reference) | 10 230 | 1.00 (Reference) |
| Yes | 4 573 | 0.84 (0.81-0.87) | 2 795 | 0.85 (0.81-0.89) |
| Treated at an NCI-designated hospital | ||||
| No | 18 936 | 1.00 (Reference) | 12 148 | 1.00 (Reference) |
| Yes | 1 382 | 0.96 (0.90-1.01) | 880 | 0.90 (0.84-0.96) |
| Urbanicity | ||||
| Urban | 13 351 | 1.00 (Reference) | 8 629 | 1.00 (Reference) |
| Nonurban | 6 256 | 0.96 (0.93-0.99) | 3 977 | 0.95 (0.91-0.99) |
| Unknown | 712 | 0.93 (0.86-1.00) | 422 | 0.89 (0.81-0.99) |
| Neighborhood SES quintile | ||||
| 1. Lowest 20% | 3 079 | 1.34 (1.27-1.40) | 1 905 | 1.24 (1.16-1.32) |
| 2 | 3 885 | 1.26 (1.20-1.32) | 2 525 | 1.23 (1.16-1.30) |
| 3 | 4 295 | 1.17 (1.12-1.22) | 2 731 | 1.12 (1.06-1.18) |
| 4 | 4 528 | 1.09 (1.05-1.14) | 2 915 | 1.07 (1.02-1.13) |
| 5. Highest 20% | 4 532 | 1.00 (Reference) | 2 952 | 1.00 (Reference) |
| Ptrend < 0.01 | Ptrend < 0.01 | |||
| Limited to patients who were diagnosed after 2001 and were under the age of 65 y | ||||
| Insurance status‡ | ||||
| Private/military insurance | 1 192 | 1.00 (Reference) | 895 | 1.00 (Reference) |
| Public insurance/no insurance | 846 | 1.54 (1.40-1.69) | 597 | 1.46 (1.30-1.63) |
| Unknown | 240 | 1.00 (0.87-1.15) | 184 | 1.07 (0.91-1.25) |
| Characteristics . | All-cause mortality . | DLBCL-specific mortality . | ||
|---|---|---|---|---|
| No. of deaths . | HR (95% CI) . | No. of deaths . | HR (95% CI) . | |
| Age at diagnosis | 1.04 (1.04-1.04) | 1.03 (1.03-1.03) | ||
| Race/ethnicity | ||||
| Non-Hispanic white | 14 148 | 1.00 (Reference) | 9 008 | 1.00 (Reference) |
| African American | 787 | 1.00 (0.93-1.08) | 489 | 0.94 (0.86-1.03) |
| Hispanic | 3 405 | 1.04 (1.00-1.08) | 2 193 | 1.02 (0.97-1.07) |
| Asian/Pacific Islander | 1 979 | 1.03 (0.98-1.08) | 1 338 | 1.08 (1.02-1.15) |
| Sex | ||||
| Male | 10 819 | 1.00 (Reference) | 6 792 | 1.00 (Reference) |
| Female | 9 500 | 0.82 (0.79-0.84) | 6 236 | 0.90 (0.87-0.94) |
| Marital status at diagnosis | ||||
| Married | 11 222 | 1.00 (Reference) | 7 278 | 1.00 (Reference) |
| Never married | 2 482 | 1.22 (1.16-1.27) | 1 611 | 1.13 (1.07-1.20) |
| Previously married | 6 061 | 1.19 (1.15-1.23) | 3 804 | 1.13 (1.09-1.18) |
| Unknown | 554 | 0.97 (0.89-1.06) | 335 | 0.91 (0.81-1.01) |
| Period of diagnosis | ||||
| 1988-2000 | 12 832 | 1.00 (Reference) | 7 838 | 1.00 (Reference) |
| 2001-2009 | 7 487 | 0.71 (0.68-0.73) | 5 190 | 0.69 (0.67-0.72) |
| B symptoms | ||||
| Absent | 7 090 | 1.00 (Reference) | 4 427 | 1.00 (Reference) |
| Present | 4 832 | 1.33 (1.28-1.38) | 3 511 | 1.45 (1.38-1.52) |
| Unknown | 8 397 | 1.12 (1.09-1.16) | 5 090 | 1.14 (1.09-1.19) |
| Nodal status | ||||
| Nodal | 13 638 | 1.00 (Reference) | 9 110 | 1.00 (Reference) |
| Extranodal | 6 681 | 1.01 (0.98-1.04) | 3 918 | 0.97 (0.93-1.01) |
| Chemotherapy | ||||
| No | 5 815 | 1.00 (Reference) | 3 461 | 1.00 (Reference) |
| Yes | 14 117 | 0.52 (0.50-0.54) | 9 339 | 0.53 (0.51-0.55) |
| Unknown | 387 | 0.52 (0.47-0.58) | 228 | 0.52 (0.45-0.59) |
| Radiation | ||||
| No | 15 742 | 1.00 (Reference) | 10 230 | 1.00 (Reference) |
| Yes | 4 573 | 0.84 (0.81-0.87) | 2 795 | 0.85 (0.81-0.89) |
| Treated at an NCI-designated hospital | ||||
| No | 18 936 | 1.00 (Reference) | 12 148 | 1.00 (Reference) |
| Yes | 1 382 | 0.96 (0.90-1.01) | 880 | 0.90 (0.84-0.96) |
| Urbanicity | ||||
| Urban | 13 351 | 1.00 (Reference) | 8 629 | 1.00 (Reference) |
| Nonurban | 6 256 | 0.96 (0.93-0.99) | 3 977 | 0.95 (0.91-0.99) |
| Unknown | 712 | 0.93 (0.86-1.00) | 422 | 0.89 (0.81-0.99) |
| Neighborhood SES quintile | ||||
| 1. Lowest 20% | 3 079 | 1.34 (1.27-1.40) | 1 905 | 1.24 (1.16-1.32) |
| 2 | 3 885 | 1.26 (1.20-1.32) | 2 525 | 1.23 (1.16-1.30) |
| 3 | 4 295 | 1.17 (1.12-1.22) | 2 731 | 1.12 (1.06-1.18) |
| 4 | 4 528 | 1.09 (1.05-1.14) | 2 915 | 1.07 (1.02-1.13) |
| 5. Highest 20% | 4 532 | 1.00 (Reference) | 2 952 | 1.00 (Reference) |
| Ptrend < 0.01 | Ptrend < 0.01 | |||
| Limited to patients who were diagnosed after 2001 and were under the age of 65 y | ||||
| Insurance status‡ | ||||
| Private/military insurance | 1 192 | 1.00 (Reference) | 895 | 1.00 (Reference) |
| Public insurance/no insurance | 846 | 1.54 (1.40-1.69) | 597 | 1.46 (1.30-1.63) |
| Unknown | 240 | 1.00 (0.87-1.15) | 184 | 1.07 (0.91-1.25) |
Cox models were adjusted for all of the characteristics shown in the table except for insurance status.
Stage at diagnosis (localized, regional, advanced, and unknown) was included as a stratifying variable.
Public insurance included Medicaid and other government-assisted programs; and private insurance included health maintenance organizations, preferred provider organizations, managed care NOS, and military care.