Nonhematologic toxicity: induction cycle 1
| Toxicity . | Standard group, n = 93 . | VPA group, n= 83 . | Grade 3/4 . | ||||
|---|---|---|---|---|---|---|---|
| Grade 3 . | Grade 4 . | Grade 3/4 . | Grade 3 . | Grade 4 . | Grade 3/4 . | P . | |
| Cardiac, n (%) | 2 (2.2) | 5 (5.4) | 7 (7.5) | 1 (1.2) | 2 (2.4) | 3 (3.6) | .34 |
| Gastrointestinal, n (%) | 10 (10.8) | 0 | 10 (10.8) | 10 (12.0) | 2 (2.4) | 12 (14.5) | .50 |
| Hemorrhage, n (%) | 2 (2.2) | 4 (4.3) | 6 (6.4) | 1 (1.2) | 2 (2.4) | 3 (3.6) | .50 |
| Infections, n (%) | 55 (59.1) | 13 (14.0) | 68 (73.1) | 33 (39.8) | 20 (24.1) | 53 (63.9) | .20 |
| Neurology, n (%) | 0 (0) | 1 (1.1) | 1 (1.1) | 6 (7.2) | 3 (3.6) | 9 (10.8) | .007 |
| Pulmonary, n (%) | 2 (2.1) | 8 (8.6) | 10 (10.7) | 4 (4.8) | 14 (16.9) | 18 (21.7) | .06 |
| Other, n (%) | 21 (22.6) | 6 (6.4) | 27 (29.0) | 13 (15.7) | 6 (7.2) | 19 (22.9) | .50 |
| Toxicity . | Standard group, n = 93 . | VPA group, n= 83 . | Grade 3/4 . | ||||
|---|---|---|---|---|---|---|---|
| Grade 3 . | Grade 4 . | Grade 3/4 . | Grade 3 . | Grade 4 . | Grade 3/4 . | P . | |
| Cardiac, n (%) | 2 (2.2) | 5 (5.4) | 7 (7.5) | 1 (1.2) | 2 (2.4) | 3 (3.6) | .34 |
| Gastrointestinal, n (%) | 10 (10.8) | 0 | 10 (10.8) | 10 (12.0) | 2 (2.4) | 12 (14.5) | .50 |
| Hemorrhage, n (%) | 2 (2.2) | 4 (4.3) | 6 (6.4) | 1 (1.2) | 2 (2.4) | 3 (3.6) | .50 |
| Infections, n (%) | 55 (59.1) | 13 (14.0) | 68 (73.1) | 33 (39.8) | 20 (24.1) | 53 (63.9) | .20 |
| Neurology, n (%) | 0 (0) | 1 (1.1) | 1 (1.1) | 6 (7.2) | 3 (3.6) | 9 (10.8) | .007 |
| Pulmonary, n (%) | 2 (2.1) | 8 (8.6) | 10 (10.7) | 4 (4.8) | 14 (16.9) | 18 (21.7) | .06 |
| Other, n (%) | 21 (22.6) | 6 (6.4) | 27 (29.0) | 13 (15.7) | 6 (7.2) | 19 (22.9) | .50 |