Specific SAEs in BM vs PBSC donors
| Event . | BM . | PBSC . | Time to resolution . |
|---|---|---|---|
| Life-threatening events | 7 | 2 | |
| Major hypotension with electrocardiogram change/hypokalemia | 1 | <1 d | |
| Abdominal thrombosis, Escherichia coli septicemia | 1 | >3 mo | |
| Severe laryngospasm after extubation requiring extensive resuscitation | 1 | <1 d | |
| Postoperative hypotension, pulmonary edema | 1 | <1 d | |
| Laryngospasm, noncardiogenic pulmonary edema | 1 | <1 d | |
| Asystole ×30 s, arrhythmias, desaturation | 1 | <1 d | |
| Severe pain and anemia (hematocrit 15%) | 1 | <2 d | |
| Intracranial hemorrhage not requiring surgery | 1 | >3 mo | |
| After apheresis, fainted, pulseless requiring resuscitation, pericarditis | 1 | >3 mo | |
| Unplanned hospitalization for expected events | 38 | 17 | |
| Nausea/emesis | 8 | 6 | <1-2 d |
| Pain | 8 | 5 | <1-2 d |
| Syncope, light-headedness | 7 | 2 | <1-2 d (8 donors), <2 wk (1 donor) |
| Anesthesia issues | |||
| Hypotension | 9 | <1-2 d | |
| Urinary retention | 2 | <1 d | |
| Bradycardia | 2 | <1 d | |
| Reactive airway issues | 1 | <1 d | |
| Fever | 1 | <1 d | |
| Symptomatic hypokalemia | 3 | <1 d | |
| Panic attack in a patient with known panic disorder | 1 | <1 d | |
| Unplanned hospitalization for unexpected events | 6 | 12 | |
| Infection | |||
| Pneumonia | 1 | 1 | <2 wk |
| Sacral cellulites | 1 | <2 wk | |
| Osteomyelitis | 1 | <1 wk | |
| Possible infection: high fever | 1 | <1 wk | |
| Pulmonary edema and chest pain | 1 | <1 d | |
| Unusual pain, inflammation | |||
| Pleuritic chest pain | 1 | <1 d | |
| Chest pain/shortness of breath | 1 | <1 d | |
| Flare of old pancreatitis | 1 | <1 mo | |
| Pericarditis | 2 | <2 wk, <2 mo | |
| Inflammatory issues | |||
| Temporary granulomatous adenopathy/inflammation | 1 | >3 mo | |
| Joint inflammation | 1 | <2 wk | |
| Worrisome pain | |||
| Radiating chest pain | 1 | <1 wk | |
| Severe headache/weakness | 1 | <2 d | |
| Unusual CVC issues | |||
| Severe emesis causing CVC loss | 1 | <1 mo | |
| Tachyarrhythmia requiring monitoring with CVC placement | 1 | <1 d | |
| Uncontrolled bleeding after CVC removal | 1 | <1 d | |
| Chronic (>3 mo) or disabling events | 14 | 4 | |
| Prolonged hip, back, or joint pain | 6 | 1 | >3 mo |
| Chronic numbness, burning, or neuropathic pain | 5 | 1 | >3 mo |
| Unable to walk after harvest, eventually able to walk with a cane (did not become chronic) | 3 | <3 mo (1 donor), >3 mo (2 donors) | |
| Prolonged muscle pain, rash | 1 | >3 mo | |
| Incapacitating chronic dizziness | 1 | >3 mo | |
| Other Events | 0 | 3 | |
| Significant hematuria during granulocyte colony stimulating factor therapy. No specific renal diagnosis made, all resolved | 3 | <1 d (1 donor), >3 mo (2 donors) | |
| Total | 65 | 38 |
| Event . | BM . | PBSC . | Time to resolution . |
|---|---|---|---|
| Life-threatening events | 7 | 2 | |
| Major hypotension with electrocardiogram change/hypokalemia | 1 | <1 d | |
| Abdominal thrombosis, Escherichia coli septicemia | 1 | >3 mo | |
| Severe laryngospasm after extubation requiring extensive resuscitation | 1 | <1 d | |
| Postoperative hypotension, pulmonary edema | 1 | <1 d | |
| Laryngospasm, noncardiogenic pulmonary edema | 1 | <1 d | |
| Asystole ×30 s, arrhythmias, desaturation | 1 | <1 d | |
| Severe pain and anemia (hematocrit 15%) | 1 | <2 d | |
| Intracranial hemorrhage not requiring surgery | 1 | >3 mo | |
| After apheresis, fainted, pulseless requiring resuscitation, pericarditis | 1 | >3 mo | |
| Unplanned hospitalization for expected events | 38 | 17 | |
| Nausea/emesis | 8 | 6 | <1-2 d |
| Pain | 8 | 5 | <1-2 d |
| Syncope, light-headedness | 7 | 2 | <1-2 d (8 donors), <2 wk (1 donor) |
| Anesthesia issues | |||
| Hypotension | 9 | <1-2 d | |
| Urinary retention | 2 | <1 d | |
| Bradycardia | 2 | <1 d | |
| Reactive airway issues | 1 | <1 d | |
| Fever | 1 | <1 d | |
| Symptomatic hypokalemia | 3 | <1 d | |
| Panic attack in a patient with known panic disorder | 1 | <1 d | |
| Unplanned hospitalization for unexpected events | 6 | 12 | |
| Infection | |||
| Pneumonia | 1 | 1 | <2 wk |
| Sacral cellulites | 1 | <2 wk | |
| Osteomyelitis | 1 | <1 wk | |
| Possible infection: high fever | 1 | <1 wk | |
| Pulmonary edema and chest pain | 1 | <1 d | |
| Unusual pain, inflammation | |||
| Pleuritic chest pain | 1 | <1 d | |
| Chest pain/shortness of breath | 1 | <1 d | |
| Flare of old pancreatitis | 1 | <1 mo | |
| Pericarditis | 2 | <2 wk, <2 mo | |
| Inflammatory issues | |||
| Temporary granulomatous adenopathy/inflammation | 1 | >3 mo | |
| Joint inflammation | 1 | <2 wk | |
| Worrisome pain | |||
| Radiating chest pain | 1 | <1 wk | |
| Severe headache/weakness | 1 | <2 d | |
| Unusual CVC issues | |||
| Severe emesis causing CVC loss | 1 | <1 mo | |
| Tachyarrhythmia requiring monitoring with CVC placement | 1 | <1 d | |
| Uncontrolled bleeding after CVC removal | 1 | <1 d | |
| Chronic (>3 mo) or disabling events | 14 | 4 | |
| Prolonged hip, back, or joint pain | 6 | 1 | >3 mo |
| Chronic numbness, burning, or neuropathic pain | 5 | 1 | >3 mo |
| Unable to walk after harvest, eventually able to walk with a cane (did not become chronic) | 3 | <3 mo (1 donor), >3 mo (2 donors) | |
| Prolonged muscle pain, rash | 1 | >3 mo | |
| Incapacitating chronic dizziness | 1 | >3 mo | |
| Other Events | 0 | 3 | |
| Significant hematuria during granulocyte colony stimulating factor therapy. No specific renal diagnosis made, all resolved | 3 | <1 d (1 donor), >3 mo (2 donors) | |
| Total | 65 | 38 |