Multivariable analysis for OS
| Variable . | OS . | |
|---|---|---|
| HR . | P . | |
| Risk group (original DRI) | ||
| Low | Ref | |
| Intermediate | 1.46 | <.0001 |
| High | 2.30 | <.0001 |
| Very high | 2.97 | <.0001 |
| Age, years | ||
| <40 | Ref | |
| 40-49 | 1.11 | .006 |
| 50-64 | 1.23 | <.0001 |
| ≥65 | 1.47 | <.0001 |
| Donor/graft source* | ||
| PB MRD | Ref | |
| BM MRD | 0.94 | .45 |
| PB MUD WM | 1.12 | .0002 |
| BM MUD WM | 1.06 | .32 |
| PB MUD PM | 1.41 | <.0001 |
| BM MUD PM | 1.35 | .002 |
| PB MMRD | 1.79 | <.0001 |
| BM MMRD | 1.11 | .33 |
| PB MMUD | 1.51 | .001 |
| BM MMUD | 1.96 | .020 |
| Cord blood | 1.78 | <.0001 |
| Conditioning† | NA | NA |
| MAC | ||
| RIC | ||
| CMV serostatus | ||
| Recipient-negative | Ref | |
| Recipient-positive | 1.12 | <.0001 |
| Gender | ||
| Male to male | Ref | |
| Female to male | 1.01 | .69 |
| Female to female | 0.92 | .026 |
| Male to female | 0.94 | .050 |
| HCT-CI | ||
| 0‡ | Ref | |
| 1-2 | 1.09 | .006 |
| 3+ | 1.30 | <.0001 |
| KPS at HCT | ||
| 90-100 | Ref | |
| <90 | 1.41 | <.0001 |
| Missing | 1.20 | .005 |
| Variable . | OS . | |
|---|---|---|
| HR . | P . | |
| Risk group (original DRI) | ||
| Low | Ref | |
| Intermediate | 1.46 | <.0001 |
| High | 2.30 | <.0001 |
| Very high | 2.97 | <.0001 |
| Age, years | ||
| <40 | Ref | |
| 40-49 | 1.11 | .006 |
| 50-64 | 1.23 | <.0001 |
| ≥65 | 1.47 | <.0001 |
| Donor/graft source* | ||
| PB MRD | Ref | |
| BM MRD | 0.94 | .45 |
| PB MUD WM | 1.12 | .0002 |
| BM MUD WM | 1.06 | .32 |
| PB MUD PM | 1.41 | <.0001 |
| BM MUD PM | 1.35 | .002 |
| PB MMRD | 1.79 | <.0001 |
| BM MMRD | 1.11 | .33 |
| PB MMUD | 1.51 | .001 |
| BM MMUD | 1.96 | .020 |
| Cord blood | 1.78 | <.0001 |
| Conditioning† | NA | NA |
| MAC | ||
| RIC | ||
| CMV serostatus | ||
| Recipient-negative | Ref | |
| Recipient-positive | 1.12 | <.0001 |
| Gender | ||
| Male to male | Ref | |
| Female to male | 1.01 | .69 |
| Female to female | 0.92 | .026 |
| Male to female | 0.94 | .050 |
| HCT-CI | ||
| 0‡ | Ref | |
| 1-2 | 1.09 | .006 |
| 3+ | 1.30 | <.0001 |
| KPS at HCT | ||
| 90-100 | Ref | |
| <90 | 1.41 | <.0001 |
| Missing | 1.20 | .005 |
MMRD, mismatched related donor; MMUD, mismatched unrelated donor; MUD, matched unrelated donor; NA, not applicable; PM, partially matched; Ref, reference; WM, well-matched.
All possible combinations of graft source and donor match were considered separately in this model because there was a significant interaction between bone marrow graft and mismatched related donor when graft source and donor match were considered independently.
Models are stratified on conditioning intensity, so no HRs or P values are provided for those variables.
Includes 308 patients with missing information whose outcome is similar to that of patients with HCT-CI of 0 in this study.