Table 2 Pharmacokinetics of novel oral... | American Society of Hematology

Table 2

Pharmacokinetics of novel oral anticoagulants

Novel oral anticoagulant	Time to peak concentration (hours)	Half-life (hours)	Extent of renal excretion
Dabigatran^3,4	1-3	7-9*	80-85%
Dabigatran^3,4	1-3	7-17†	80-85%
Rivaroxaban^10,11,14	2-4	7-17*	36%
		12-13‡
		6-9†
Apixaban^15,17,18	1-3	8-14*	25%

Novel oral anticoagulant	Time to peak concentration (hours)	Half-life (hours)	Extent of renal excretion
Dabigatran^3,4	1-3	7-9*	80-85%
Dabigatran^3,4	1-3	7-17†	80-85%
Rivaroxaban^10,11,14	2-4	7-17*	36%
		12-13‡
		6-9†
Apixaban^15,17,18	1-3	8-14*	25%

Healthy adults, single dose.

Healthy adults, multiple doses.

Healthy elderly, single dose.