WM patients present with C1013G/CXCR4 somatic mutation
| . | . | CXCR4 C1013G . | |
|---|---|---|---|
| Entity . | N = 418 . | No. . | Percent . |
| WM | 131 | 37 | 28.2 |
| IgM MGUS | 40 | 8 | 20 |
| Diffuse large cell lymphoma | 75 | 1 | 1.3 |
| Splenic marginal zone lymphoma | 14 | 1 | 7 |
| B-CLL (16 with monoclonal component) | 37 | 0 | 0 |
| Hairy cell leukemia | 35 | 0 | 0 |
| Multiple myeloma (3 with IgM) | 36 | 0 | 0 |
| IgA/IgG MGUS | 22 | 0 | 0 |
| Lymphoplasmacytic lymphoma (with no WM criteria) | 13 | 0 | 0 |
| Amyloidosis | 6 | 0 | 0 |
| B-CLL disorder, NOS | 9 | 0 | 0 |
| Healthy volunteers | 32 | 0 | 0 |
| . | . | CXCR4 C1013G . | |
|---|---|---|---|
| Entity . | N = 418 . | No. . | Percent . |
| WM | 131 | 37 | 28.2 |
| IgM MGUS | 40 | 8 | 20 |
| Diffuse large cell lymphoma | 75 | 1 | 1.3 |
| Splenic marginal zone lymphoma | 14 | 1 | 7 |
| B-CLL (16 with monoclonal component) | 37 | 0 | 0 |
| Hairy cell leukemia | 35 | 0 | 0 |
| Multiple myeloma (3 with IgM) | 36 | 0 | 0 |
| IgA/IgG MGUS | 22 | 0 | 0 |
| Lymphoplasmacytic lymphoma (with no WM criteria) | 13 | 0 | 0 |
| Amyloidosis | 6 | 0 | 0 |
| B-CLL disorder, NOS | 9 | 0 | 0 |
| Healthy volunteers | 32 | 0 | 0 |
C1013G/CXCR4 variant occurs in 28% of patients with WM, being either absent or present in a minority of patient with B-cell lymphoproliferative disorders.
B-CLL, B-cell chronic lymphocytic leukemia; MGUS, monoclonal gammopathy of undetermined significance; NOS, not otherwise specified.