Table 1

The impact of platelet transfusions on platelet-count increment in critically ill patients with thrombocytopenia

ReferenceNPopulationStudy designResultsStudy quality*
Adults      
 4 1923 Medical ICU Prospective cohort Median increase was 15 × 109/L (IQR, 2-35 × 109/L) Low 
 12 350 Dengue fever Prospective cohort Median PLT count yield† was 12.4% higher than baseline after transfusion (range, −3.9%-67.1%) Low 
 9 216 Medical/surgical ICU Retrospective cohort Median increase after single PLT transfusion was 14 × 109/L (IQR, −2-30 × 109/L) Moderate 
 11 147 Surgical ICU Prospective cohort PLT count rose above 40-50 × 109/L (but never >100 × 109/L) after transfusion Low 
 10 72 Surgical ICU Case-control study Platelet transfusion led to sustained correction of thrombocytopenia in 8/16 patients; the remainder had only transient improvement Low 
Neonates      
 15 422 Preterm neonates Retrospective cohort study Platelet transfusion resulted in good, but less sustained, rise in platelet count for neonates with severe thrombocytopenia (data not shown) Low 
 14 194 Neonates Prospective cohort Fifty-nine percent of transfusions increased counts >40 × 109/L; 8% of transfusions increased counts <20 × 109/L; median platelet count increase from 27 × 109/L (IQR, 19-36 × 109/L) to 79 × 109/L (IQR, 47-126 × 109/L) Moderate 
 8 152 Preterm neonates RCT Significant increase by 95 × 109/L in the intervention group (PLT transfusions for platelets <150 × 109/L) Low 
ReferenceNPopulationStudy designResultsStudy quality*
Adults      
 4 1923 Medical ICU Prospective cohort Median increase was 15 × 109/L (IQR, 2-35 × 109/L) Low 
 12 350 Dengue fever Prospective cohort Median PLT count yield† was 12.4% higher than baseline after transfusion (range, −3.9%-67.1%) Low 
 9 216 Medical/surgical ICU Retrospective cohort Median increase after single PLT transfusion was 14 × 109/L (IQR, −2-30 × 109/L) Moderate 
 11 147 Surgical ICU Prospective cohort PLT count rose above 40-50 × 109/L (but never >100 × 109/L) after transfusion Low 
 10 72 Surgical ICU Case-control study Platelet transfusion led to sustained correction of thrombocytopenia in 8/16 patients; the remainder had only transient improvement Low 
Neonates      
 15 422 Preterm neonates Retrospective cohort study Platelet transfusion resulted in good, but less sustained, rise in platelet count for neonates with severe thrombocytopenia (data not shown) Low 
 14 194 Neonates Prospective cohort Fifty-nine percent of transfusions increased counts >40 × 109/L; 8% of transfusions increased counts <20 × 109/L; median platelet count increase from 27 × 109/L (IQR, 19-36 × 109/L) to 79 × 109/L (IQR, 47-126 × 109/L) Moderate 
 8 152 Preterm neonates RCT Significant increase by 95 × 109/L in the intervention group (PLT transfusions for platelets <150 × 109/L) Low 

IQR, interquartile range; PLT, platelet.

*

Study quality included applicability to the research question.

†

PLT yield is the platelet count increase after transfusion corrected for body weight and platelet dose.

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