Adverse events occurring in >5% of patients (n = 83)
| Event . | All events . | Grade 3 to 4 events . | ||
|---|---|---|---|---|
| No. . | % . | No. . | % . | |
| Any event | 82 | 98.8 | 52 | 62.7 |
| Fatigue | 28 | 33.7 | 8 | 9.6 |
| Nausea | 26 | 31.3 | 1 | 1.2 |
| Diarrhea | 24 | 28.9 | 2 | 2.4 |
| Neutropenia | 20 | 24.1 | 14 | 19.3 |
| Cough | 19 | 22.9 | 1 | 1.2 |
| Chills | 17 | 20.5 | 1 | 1.2 |
| Pyrexia | 17 | 20.5 | 1 | 1.2 |
| Peripheral edema | 16 | 19.3 | 0 | 0 |
| Anemia | 13 | 15.7 | 4 | 4.8 |
| Back pain | 13 | 15.7 | 2 | 2.4 |
| Dyspnea | 13 | 15.7 | 3 | 3.6 |
| Thrombocytopenia | 12 | 14.5 | 6 | 7.2 |
| Vomiting | 10 | 12.0 | 0 | 0 |
| Muscle spasms | 10 | 12.0 | 0 | 0 |
| Headache | 10 | 12.0 | 0 | 0 |
| Night sweats | 10 | 12.0 | 0 | 0 |
| Abdominal pain | 9 | 10.8 | 1 | 1.2 |
| Constipation | 9 | 10.8 | 0 | 0 |
| Hypophosphatemia | 9 | 10.8 | 5 | 6.0 |
| Infusion-related reaction | 7 | 8.4 | 1 | 1.2 |
| Decreased appetite | 7 | 8.4 | 0 | 0 |
| Hyperglycemia | 7 | 8.4 | 2 | 2.4 |
| Upper respiratory tract infection | 6 | 7.2 | 0 | 0 |
| Hypocalcemia | 6 | 7.2 | 0 | 0 |
| Dizziness | 6 | 7.2 | 0 | 0 |
| Sinus congestion | 6 | 7.2 | 1 | 1.2 |
| Febrile neutropenia | 5 | 6.0 | 5 | 6.0 |
| Abdominal distension | 5 | 6.0 | 0 | 0 |
| Sinusitis | 5 | 6.0 | 0 | 0 |
| Hypokalemia | 5 | 6.0 | 2 | 2.4 |
| Arthralgia | 5 | 6.0 | 0 | 0 |
| Insomnia | 5 | 6.0 | 0 | 0 |
| Pollakiuria | 5 | 6.0 | 0 | 0 |
| Pharyngolaryngeal pain | 5 | 6.0 | 0 | 0 |
| Event . | All events . | Grade 3 to 4 events . | ||
|---|---|---|---|---|
| No. . | % . | No. . | % . | |
| Any event | 82 | 98.8 | 52 | 62.7 |
| Fatigue | 28 | 33.7 | 8 | 9.6 |
| Nausea | 26 | 31.3 | 1 | 1.2 |
| Diarrhea | 24 | 28.9 | 2 | 2.4 |
| Neutropenia | 20 | 24.1 | 14 | 19.3 |
| Cough | 19 | 22.9 | 1 | 1.2 |
| Chills | 17 | 20.5 | 1 | 1.2 |
| Pyrexia | 17 | 20.5 | 1 | 1.2 |
| Peripheral edema | 16 | 19.3 | 0 | 0 |
| Anemia | 13 | 15.7 | 4 | 4.8 |
| Back pain | 13 | 15.7 | 2 | 2.4 |
| Dyspnea | 13 | 15.7 | 3 | 3.6 |
| Thrombocytopenia | 12 | 14.5 | 6 | 7.2 |
| Vomiting | 10 | 12.0 | 0 | 0 |
| Muscle spasms | 10 | 12.0 | 0 | 0 |
| Headache | 10 | 12.0 | 0 | 0 |
| Night sweats | 10 | 12.0 | 0 | 0 |
| Abdominal pain | 9 | 10.8 | 1 | 1.2 |
| Constipation | 9 | 10.8 | 0 | 0 |
| Hypophosphatemia | 9 | 10.8 | 5 | 6.0 |
| Infusion-related reaction | 7 | 8.4 | 1 | 1.2 |
| Decreased appetite | 7 | 8.4 | 0 | 0 |
| Hyperglycemia | 7 | 8.4 | 2 | 2.4 |
| Upper respiratory tract infection | 6 | 7.2 | 0 | 0 |
| Hypocalcemia | 6 | 7.2 | 0 | 0 |
| Dizziness | 6 | 7.2 | 0 | 0 |
| Sinus congestion | 6 | 7.2 | 1 | 1.2 |
| Febrile neutropenia | 5 | 6.0 | 5 | 6.0 |
| Abdominal distension | 5 | 6.0 | 0 | 0 |
| Sinusitis | 5 | 6.0 | 0 | 0 |
| Hypokalemia | 5 | 6.0 | 2 | 2.4 |
| Arthralgia | 5 | 6.0 | 0 | 0 |
| Insomnia | 5 | 6.0 | 0 | 0 |
| Pollakiuria | 5 | 6.0 | 0 | 0 |
| Pharyngolaryngeal pain | 5 | 6.0 | 0 | 0 |