Platelet proteins differentially expressed in hypoxia-exposed animals
| Protein description . | Accession . | Mol wt . | Fold change . | Mowse score . | General function . |
|---|---|---|---|---|---|
| Apolipoprotein E | APOE_RAT | 35.7 | −4.2 | 214 | Mediates the binding, internalization, and catabolism of lipoprotein particles |
| Actin related Protein 2 | ARP2_RAT | 44.7 | −4.2 | 101 | Regulation of actin polymerization |
| Calpain small subunit 1 | CSS1_RAT | 28.5 | 5.3 | 38 | Regulation of calpain activity, cell migration |
| Calreticulin | CALR_RAT | 48 | −6.0 | 347 | Molecular calcium-binding chaperone, quality control in the endoplasmic reticulum, vascular regulatory antithrombotic role |
| Calumenin | CALU_RAT | 37 | −6.2 | 60 | Vascular regulatory, regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues |
| Complement C3 precursor | CO3_RAT | 186 | −2.5 | 178 | Activation of the complement system |
| Coronin1A | COR1A_RAT | 51 | −2.9 | 74 | A crucial component of the cytoskeleton of highly motile cells |
| Elongation factor 1 γ | EF1G_RAT | 50 | −2.2 | 92 | Protein synthesis |
| α Enolase | ENOA_RAT | 47.1 | 3.0 | 68 | Activator of the complement system and a mediator of the local inflammatory response glycolysis, plays a part in growth control, hypoxia tolerance, and allergic responses |
| Fibrinogen α | FIBA_RAT | 86.6 | 2.7 | 90 | Yield monomers that polymerize into fibrin and acts as a cofactor in platelet aggregation |
| Fibrinogen γ | FIBG_RAT | 50.6 | 3.3 | 357 | Yield monomers that polymerize into fibrin and acts as a cofactor in platelet aggregation |
| Guanine nucleotide binding protein 2 | GBB2_RAT | 37.3 | −3.0 | 63 | Glycoproteins bound to plasma membrane, involved as a modulator or transducer in various transmembrane signaling systems |
| TF precursor | TF_RAT | 33.4 | 2.1 | 20 | Key component of extrinsic coagulation pathway |
| Haptoglobin precursor | HPT_RAT | 38.5 | 2.5 | 71 | Combines with free plasma hemoglobin, preventing loss of iron through the kidneys, secreted in response to hypoxia as well as acute inflammation |
| Heat shock cognate 71 | HSP7C_RAT | 70.8 | 2.3 | 150 | Chaperon, regulation of transcription, response to stress |
| T kininogen 1 | KNT1_RAT | 47.7 | 3.6 | 117 | Acute-phase protein |
| Myosin light chain PP 6 | MYL6_RAT | 16.9 | 5.9 | 87 | Motor protein, also involved in collagen-induced platelet activation |
| Tropomyosin α 1 | TPM1_RAT | 32.6 | 4.2 | 50 | Binds to actin filaments, cytoskeletal reorganization |
| Tropomyosin β | TPM2_RAT | 32.8 | 4.6 | 96 | Binds to actin filaments, cytoskeletal reorganization |
| Tropomyosin α 4 | TPM4_RAT | 28.5 | 2.0 | 64 | Binds to actin filaments, cytoskeletal reorganization |
| Serrotransferrin precursor | TRFE_RAT | 76.3 | 2.4 | 108 | Precursor to macromolecular activators of phagocytosis which enhance leukocyte phagocytosis |
| Janus Kinase 3 | JAK3_RAT | 122 | 3.6 | 26 | Cytokine-mediated signaling and regulation of cytosolic calcium. |
| α-1-antitrypsin | A1AT_RAT | 46.1 | 4.2 | 50 | Inhibitor of serine proteases; platelet isoform secreted in α granules |
| ρ Guanine nucleotide exchange factor 7 | ARHG7_RAT | 73 | 4.2 | 19 | Involved in ras-related C3 botulinum toxin substrate 1-dependent signaling, cell migration, attachment, and cell spreading. |
| Vitamin D binding Protein | VTDB_RAT | 53.5 | 2.0 | 99 | Carries vitamin D in plasma, has T lymphocyte surface association |
| α-2-macroglobulin receptor-associated protein precursor | AMRP_RAT | 42 | 5.7 | 33 | Binds to members of low-density lipoprotein receptor family and inhibits binding of their ligands |
| Nonmuscle caldesmon (L- caldesmon) | CALD1_RAT | 60.5 | 3.1 | 49 | Actin and myosin binding protein implicated in regulation of actomyosin interactions |
| Protein description . | Accession . | Mol wt . | Fold change . | Mowse score . | General function . |
|---|---|---|---|---|---|
| Apolipoprotein E | APOE_RAT | 35.7 | −4.2 | 214 | Mediates the binding, internalization, and catabolism of lipoprotein particles |
| Actin related Protein 2 | ARP2_RAT | 44.7 | −4.2 | 101 | Regulation of actin polymerization |
| Calpain small subunit 1 | CSS1_RAT | 28.5 | 5.3 | 38 | Regulation of calpain activity, cell migration |
| Calreticulin | CALR_RAT | 48 | −6.0 | 347 | Molecular calcium-binding chaperone, quality control in the endoplasmic reticulum, vascular regulatory antithrombotic role |
| Calumenin | CALU_RAT | 37 | −6.2 | 60 | Vascular regulatory, regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues |
| Complement C3 precursor | CO3_RAT | 186 | −2.5 | 178 | Activation of the complement system |
| Coronin1A | COR1A_RAT | 51 | −2.9 | 74 | A crucial component of the cytoskeleton of highly motile cells |
| Elongation factor 1 γ | EF1G_RAT | 50 | −2.2 | 92 | Protein synthesis |
| α Enolase | ENOA_RAT | 47.1 | 3.0 | 68 | Activator of the complement system and a mediator of the local inflammatory response glycolysis, plays a part in growth control, hypoxia tolerance, and allergic responses |
| Fibrinogen α | FIBA_RAT | 86.6 | 2.7 | 90 | Yield monomers that polymerize into fibrin and acts as a cofactor in platelet aggregation |
| Fibrinogen γ | FIBG_RAT | 50.6 | 3.3 | 357 | Yield monomers that polymerize into fibrin and acts as a cofactor in platelet aggregation |
| Guanine nucleotide binding protein 2 | GBB2_RAT | 37.3 | −3.0 | 63 | Glycoproteins bound to plasma membrane, involved as a modulator or transducer in various transmembrane signaling systems |
| TF precursor | TF_RAT | 33.4 | 2.1 | 20 | Key component of extrinsic coagulation pathway |
| Haptoglobin precursor | HPT_RAT | 38.5 | 2.5 | 71 | Combines with free plasma hemoglobin, preventing loss of iron through the kidneys, secreted in response to hypoxia as well as acute inflammation |
| Heat shock cognate 71 | HSP7C_RAT | 70.8 | 2.3 | 150 | Chaperon, regulation of transcription, response to stress |
| T kininogen 1 | KNT1_RAT | 47.7 | 3.6 | 117 | Acute-phase protein |
| Myosin light chain PP 6 | MYL6_RAT | 16.9 | 5.9 | 87 | Motor protein, also involved in collagen-induced platelet activation |
| Tropomyosin α 1 | TPM1_RAT | 32.6 | 4.2 | 50 | Binds to actin filaments, cytoskeletal reorganization |
| Tropomyosin β | TPM2_RAT | 32.8 | 4.6 | 96 | Binds to actin filaments, cytoskeletal reorganization |
| Tropomyosin α 4 | TPM4_RAT | 28.5 | 2.0 | 64 | Binds to actin filaments, cytoskeletal reorganization |
| Serrotransferrin precursor | TRFE_RAT | 76.3 | 2.4 | 108 | Precursor to macromolecular activators of phagocytosis which enhance leukocyte phagocytosis |
| Janus Kinase 3 | JAK3_RAT | 122 | 3.6 | 26 | Cytokine-mediated signaling and regulation of cytosolic calcium. |
| α-1-antitrypsin | A1AT_RAT | 46.1 | 4.2 | 50 | Inhibitor of serine proteases; platelet isoform secreted in α granules |
| ρ Guanine nucleotide exchange factor 7 | ARHG7_RAT | 73 | 4.2 | 19 | Involved in ras-related C3 botulinum toxin substrate 1-dependent signaling, cell migration, attachment, and cell spreading. |
| Vitamin D binding Protein | VTDB_RAT | 53.5 | 2.0 | 99 | Carries vitamin D in plasma, has T lymphocyte surface association |
| α-2-macroglobulin receptor-associated protein precursor | AMRP_RAT | 42 | 5.7 | 33 | Binds to members of low-density lipoprotein receptor family and inhibits binding of their ligands |
| Nonmuscle caldesmon (L- caldesmon) | CALD1_RAT | 60.5 | 3.1 | 49 | Actin and myosin binding protein implicated in regulation of actomyosin interactions |