Treatment-related adverse events during induction
| Events, n (%) . | N = 56 . | |
|---|---|---|
| Any grade . | Grades 3 to 5 . | |
| Hematologic | ||
| ≥1 event | 44 (79) | 15 (27) |
| Neutropenia | 20 (36) | 11 (20) |
| Thrombocytopenia | 21 (38) | 2 (4) |
| Anemia | 39 (70) | 6 (11) |
| Nonhematologic | ||
| ≥1 event | 40 (71) | 16 (29) |
| Cardiac events | 9 (16) | 4 (7) |
| Arrhythmia | 2 (4) | 1 (2) |
| Myocardial infarction | 1 (2) | 1 (2) |
| Heart failure | 1 (2) | 1 (2) |
| Hypertension | 5 (9) | 1 (2) |
| Vascular events | 3 (5) | 1 (2) |
| Pulmonary thromboembolism | 1 (2) | 1 (2) |
| Phlebitis | 2 (4) | — |
| Constitutional events | 34 (61) | 2 (4) |
| Edema | 7 (13) | — |
| Fever | 14 (25) | 1 (2) |
| Fatigue | 11 (20) | 1 (2) |
| Dermatologic events | 5 (9) | — |
| Gastrointestinal events | 25 (45) | 1 (2) |
| Constipation | 3 (5) | — |
| Diarrhea | 8 (14) | — |
| Nausea/vomiting | 11 (20) | — |
| Intestinal perforation | 1 (2) | 1 (2) |
| Other | 2 (4) | — |
| Infection events | 10 (18) | 3 (5) |
| Upper respiratory tract | 6 (11) | 1 (2) |
| Pneumonia | 2 (4) | 2 (4) |
| Febrile neutropenia | 1 (2) | 1 (2) |
| Genitourinary tract | 1 (2) | — |
| Neurological events | 15 (27) | 2 (4) |
| Sensitive PN | 4 (7) | — |
| Motor PN | 1 (2) | — |
| Mood alteration | 1 (2) | 1 (2) |
| Stroke | 1 (2) | 1 (2) |
| Other | 8 (14) | — |
| Metabolic events | 19 (34) | 5 (9) |
| AST/ALT increase | 4 (7) | — |
| Hyperglycemia | 7 (13) | 1 (2) |
| Hypoglycemia | 1 (2) | — |
| Lymphopenia | 5 (9) | 4 (7) |
| Other | 2 (4) | — |
| Renal events | 3 (5) | 2 (4) |
| Respiratory events | 9 (16) | 1 (2) |
| Dyspnea | 4 (7) | — |
| Respiratory failure | 1 (2) | — |
| Acute pulmonary edema | 1 (2) | 1 (2) |
| Other | 3 (5) | — |
| Other events | 6 (11) | — |
| Events, n (%) . | N = 56 . | |
|---|---|---|
| Any grade . | Grades 3 to 5 . | |
| Hematologic | ||
| ≥1 event | 44 (79) | 15 (27) |
| Neutropenia | 20 (36) | 11 (20) |
| Thrombocytopenia | 21 (38) | 2 (4) |
| Anemia | 39 (70) | 6 (11) |
| Nonhematologic | ||
| ≥1 event | 40 (71) | 16 (29) |
| Cardiac events | 9 (16) | 4 (7) |
| Arrhythmia | 2 (4) | 1 (2) |
| Myocardial infarction | 1 (2) | 1 (2) |
| Heart failure | 1 (2) | 1 (2) |
| Hypertension | 5 (9) | 1 (2) |
| Vascular events | 3 (5) | 1 (2) |
| Pulmonary thromboembolism | 1 (2) | 1 (2) |
| Phlebitis | 2 (4) | — |
| Constitutional events | 34 (61) | 2 (4) |
| Edema | 7 (13) | — |
| Fever | 14 (25) | 1 (2) |
| Fatigue | 11 (20) | 1 (2) |
| Dermatologic events | 5 (9) | — |
| Gastrointestinal events | 25 (45) | 1 (2) |
| Constipation | 3 (5) | — |
| Diarrhea | 8 (14) | — |
| Nausea/vomiting | 11 (20) | — |
| Intestinal perforation | 1 (2) | 1 (2) |
| Other | 2 (4) | — |
| Infection events | 10 (18) | 3 (5) |
| Upper respiratory tract | 6 (11) | 1 (2) |
| Pneumonia | 2 (4) | 2 (4) |
| Febrile neutropenia | 1 (2) | 1 (2) |
| Genitourinary tract | 1 (2) | — |
| Neurological events | 15 (27) | 2 (4) |
| Sensitive PN | 4 (7) | — |
| Motor PN | 1 (2) | — |
| Mood alteration | 1 (2) | 1 (2) |
| Stroke | 1 (2) | 1 (2) |
| Other | 8 (14) | — |
| Metabolic events | 19 (34) | 5 (9) |
| AST/ALT increase | 4 (7) | — |
| Hyperglycemia | 7 (13) | 1 (2) |
| Hypoglycemia | 1 (2) | — |
| Lymphopenia | 5 (9) | 4 (7) |
| Other | 2 (4) | — |
| Renal events | 3 (5) | 2 (4) |
| Respiratory events | 9 (16) | 1 (2) |
| Dyspnea | 4 (7) | — |
| Respiratory failure | 1 (2) | — |
| Acute pulmonary edema | 1 (2) | 1 (2) |
| Other | 3 (5) | — |
| Other events | 6 (11) | — |
ALT, alanine aminotransferase; AST, aspartate aminotransferase.