Table 1 Two novel SNPs associated with... | American Society of Hematology

Table 1

Two novel SNPs associated with MM risk

SNP	Risk allele	MM cases					Controls					OR	P*	P†
SNP	Risk allele	N	Genotypes			RAF	N	Genotypes			RAF	OR	P*	P†
rs12614346 (2q12.3)	A		AA	AG	GG			AA	AG	GG
Discovery		972	126	462	384	0.37	1064	89	449	526	0.29	1.39	7.1E−07	1.7E−05
Replication		249	38	102	109	0.36						1.33	.007
rs73486634 (9q22.33)	G		GG	GA	AA			GG	GA	AA
Discovery		971	5	85	881	0.05	1064	0	47	1017	0.02	2.28	4.7E−06	6.3E−04
Replication		249	0	14	235	0.03						1.28	.416

SNP	Risk allele	MM cases					Controls					OR	P*	P†
SNP	Risk allele	N	Genotypes			RAF	N	Genotypes			RAF	OR	P*	P†
rs12614346 (2q12.3)	A		AA	AG	GG			AA	AG	GG
Discovery		972	126	462	384	0.37	1064	89	449	526	0.29	1.39	7.1E−07	1.7E−05
Replication		249	38	102	109	0.36						1.33	.007
rs73486634 (9q22.33)	G		GG	GA	AA			GG	GA	AA
Discovery		971	5	85	881	0.05	1064	0	47	1017	0.02	2.28	4.7E−06	6.3E−04
Replication		249	0	14	235	0.03						1.28	.416

OR, odds ratio; RAF, risk allele frequency.

Cochran-Armitage trend test.

Logistic regression assuming additive inheritance and including 4 genome-wide multidimensional scaling parameters as covariates.