Presenting features of 1004 patients with ET or PMF, stratified by their mutational status
| . | JAK2 mutated (A) . | CALR mutated (B) . | Triple negative (C) . | MPL mutated (D) . | P . | |||
|---|---|---|---|---|---|---|---|---|
| A vs B . | A vs C . | B vs C . | A vs D . | |||||
| ET, N = 576 | ||||||||
| No. of patients | 336 | 134 | 84 | 22 | ||||
| Age, median (range), y | 58 (16-88) | 49 (13-91) | 47 (16-81) | 57 (22-85) | <.0001 | .0004 | .8 | 1.0 |
| Age ≥60 y, n (%) | 157 (47) | 36 (27) | 29 (34) | 8 (36) | <.0001 | .04 | .2 | .3 |
| Females, n (%) | 227 (68) | 66 (49) | 61 (73) | 13 (59) | .0002 | .4 | .0007 | .4 |
| Hemoglobin, median (range), g/dL | 14.3 (9.8-17.9) | 13.5 (6.9-16.4) | 13.2 (8.4-16.7) | 13.8 (9.0-16.0) | <.0001 | <.0001 | .7 | .02 |
| Leukocytes, median (range), ×109/L | 9.6 (3.5-53.4) | 8.5 (2.6-32.6) | 8.3 (2.8-15.4) | 7.4 (4.0-17.7) | .0007 | .0006 | .6 | .07 |
| Platelets, median (range), ×109/L | 841 (469-3000) | 1000 (454-3460) | 854 (500-3300) | 900 (685-2249) | <.0001 | .4 | .003 | .1 |
| Leukocytes ≥11 × 109/L, % | 31 | 24 | 20 | 26 | .1 | .04 | .5 | .6 |
| Platelets >1000 × 109/L, % | 29 | 54 | 38 | 41 | <.0001 | .1 | .02 | .2 |
| Thrombosis history, % | 37 | 27 | 20 | 45 | .04 | .004 | .3 | .4 |
| PMF, N = 428 | ||||||||
| No. of patients | 258 | 92 | 52 | 26 | ||||
| Age, median (range), y | 65 (28-90) | 54 (18-83) | 67 (14-88) | 60 (29-80) | <.0001 | .3 | <.0001 | .046 |
| Age ≥60 y, n (%) | 173 (67%) | 35 (38%) | 39 (75%) | 15 (58%) | <.0001 | .3 | <.0001 | .3 |
| Females, n (%) | 88 (34%) | 39 (42%) | 18 (35%) | 9 (35%) | .1 | .9 | .4 | 1.0 |
| Hemoglobin, median (range), g/dL | 11.0 (5.4-17.5) | 11.3 (8.0-15.5) | 9.6 (5.2-13.5) | 10.2 (6-14) | .3 | <.0001 | <.0001 | .08 |
| Leukocytes, median (range), ×109/L | 9.9 (0.8-106.1) | 8.0 (1.8-40.0) | 6.7 (1.4-146.6) | 5.8 (2.5-42.0) | .003 | .1 | .7 | .03 |
| Platelets, median (range), ×109/L | 260 (12-2466) | 387 (15-1563) | 147 (14-900) | 179 (31-925) | <.0001 | .001 | <.0001 | .06 |
| Leukocytes ≥11 × 109/L, % | 46 | 23 | 41 | 33 | .0002 | .5 | .03 | .2 |
| Platelets >1000 × 109/L, % | 3 | 9 | 0 | 0 | .02 | .2 | .03 | .4 |
| . | JAK2 mutated (A) . | CALR mutated (B) . | Triple negative (C) . | MPL mutated (D) . | P . | |||
|---|---|---|---|---|---|---|---|---|
| A vs B . | A vs C . | B vs C . | A vs D . | |||||
| ET, N = 576 | ||||||||
| No. of patients | 336 | 134 | 84 | 22 | ||||
| Age, median (range), y | 58 (16-88) | 49 (13-91) | 47 (16-81) | 57 (22-85) | <.0001 | .0004 | .8 | 1.0 |
| Age ≥60 y, n (%) | 157 (47) | 36 (27) | 29 (34) | 8 (36) | <.0001 | .04 | .2 | .3 |
| Females, n (%) | 227 (68) | 66 (49) | 61 (73) | 13 (59) | .0002 | .4 | .0007 | .4 |
| Hemoglobin, median (range), g/dL | 14.3 (9.8-17.9) | 13.5 (6.9-16.4) | 13.2 (8.4-16.7) | 13.8 (9.0-16.0) | <.0001 | <.0001 | .7 | .02 |
| Leukocytes, median (range), ×109/L | 9.6 (3.5-53.4) | 8.5 (2.6-32.6) | 8.3 (2.8-15.4) | 7.4 (4.0-17.7) | .0007 | .0006 | .6 | .07 |
| Platelets, median (range), ×109/L | 841 (469-3000) | 1000 (454-3460) | 854 (500-3300) | 900 (685-2249) | <.0001 | .4 | .003 | .1 |
| Leukocytes ≥11 × 109/L, % | 31 | 24 | 20 | 26 | .1 | .04 | .5 | .6 |
| Platelets >1000 × 109/L, % | 29 | 54 | 38 | 41 | <.0001 | .1 | .02 | .2 |
| Thrombosis history, % | 37 | 27 | 20 | 45 | .04 | .004 | .3 | .4 |
| PMF, N = 428 | ||||||||
| No. of patients | 258 | 92 | 52 | 26 | ||||
| Age, median (range), y | 65 (28-90) | 54 (18-83) | 67 (14-88) | 60 (29-80) | <.0001 | .3 | <.0001 | .046 |
| Age ≥60 y, n (%) | 173 (67%) | 35 (38%) | 39 (75%) | 15 (58%) | <.0001 | .3 | <.0001 | .3 |
| Females, n (%) | 88 (34%) | 39 (42%) | 18 (35%) | 9 (35%) | .1 | .9 | .4 | 1.0 |
| Hemoglobin, median (range), g/dL | 11.0 (5.4-17.5) | 11.3 (8.0-15.5) | 9.6 (5.2-13.5) | 10.2 (6-14) | .3 | <.0001 | <.0001 | .08 |
| Leukocytes, median (range), ×109/L | 9.9 (0.8-106.1) | 8.0 (1.8-40.0) | 6.7 (1.4-146.6) | 5.8 (2.5-42.0) | .003 | .1 | .7 | .03 |
| Platelets, median (range), ×109/L | 260 (12-2466) | 387 (15-1563) | 147 (14-900) | 179 (31-925) | <.0001 | .001 | <.0001 | .06 |
| Leukocytes ≥11 × 109/L, % | 46 | 23 | 41 | 33 | .0002 | .5 | .03 | .2 |
| Platelets >1000 × 109/L, % | 3 | 9 | 0 | 0 | .02 | .2 | .03 | .4 |
Percentages are rounded up to the nearest whole percent.