Angiogenic gene signatures
| . | P value . | . | . | |
|---|---|---|---|---|
| Gene set . | NES . | Nominal . | FDR q value . | Upregulated in class . |
| Enriched in SOX11-positive (n = 4) vs SOX11-knockdown (n = 10) xenograft tumors | ||||
| LU_TUMOR_ANGIOGENESIS_UP | 1.606 | .025 | 0.1 | Z138 SOX11-positive xenograft tumors |
| REACTOME_PI_3K_CASCADE | 1.833 | .002 | 0.04 | Z138 SOX11-positive xenograft tumors |
| Enriched in leukemic SOX11-expressing (n = 16) vs SOX11-negative (n = 22) MCL primary tumors | ||||
| LU_TUMOR_VASCULATURE_UP | 1.51 | .03 | 0.12 | SOX11-expressing leukemic MCL primary tumors |
| ANGIOGENESIS | 1.51 | .02 | 0.1 | SOX11-expressing leukemic MCL primary tumors |
| VASCULATURE_DEVELOPMENT | 1.44 | .04 | 0.18 | SOX11-expressing leukemic MCL primary tumors |
| REGULATION_OF_ANGIOGENESIS | 1.44 | .04 | 0.14 | SOX11-expressing leukemic MCL primary tumors |
| LU_TUMOR_ENDOTHELIAL_MARKERS_UP | 1.60 | .02 | 0.11 | SOX11-expressing leukemic MCL primary tumors |
| Enriched in SOX11-positive (n = 2) vs SOX11-silenced (n = 4) MCL cell lines | ||||
| LU_TUMOR_ANGIOGENESIS_UP | 1.646 | .01 | 0.06 | Z138 SOX11-positive MCL cell line |
| . | P value . | . | . | |
|---|---|---|---|---|
| Gene set . | NES . | Nominal . | FDR q value . | Upregulated in class . |
| Enriched in SOX11-positive (n = 4) vs SOX11-knockdown (n = 10) xenograft tumors | ||||
| LU_TUMOR_ANGIOGENESIS_UP | 1.606 | .025 | 0.1 | Z138 SOX11-positive xenograft tumors |
| REACTOME_PI_3K_CASCADE | 1.833 | .002 | 0.04 | Z138 SOX11-positive xenograft tumors |
| Enriched in leukemic SOX11-expressing (n = 16) vs SOX11-negative (n = 22) MCL primary tumors | ||||
| LU_TUMOR_VASCULATURE_UP | 1.51 | .03 | 0.12 | SOX11-expressing leukemic MCL primary tumors |
| ANGIOGENESIS | 1.51 | .02 | 0.1 | SOX11-expressing leukemic MCL primary tumors |
| VASCULATURE_DEVELOPMENT | 1.44 | .04 | 0.18 | SOX11-expressing leukemic MCL primary tumors |
| REGULATION_OF_ANGIOGENESIS | 1.44 | .04 | 0.14 | SOX11-expressing leukemic MCL primary tumors |
| LU_TUMOR_ENDOTHELIAL_MARKERS_UP | 1.60 | .02 | 0.11 | SOX11-expressing leukemic MCL primary tumors |
| Enriched in SOX11-positive (n = 2) vs SOX11-silenced (n = 4) MCL cell lines | ||||
| LU_TUMOR_ANGIOGENESIS_UP | 1.646 | .01 | 0.06 | Z138 SOX11-positive MCL cell line |
GSEA was used to test for significant enrichment of defined gene signatures related to angiogenesis. NES and FDR P values are shown and significance is considered when FDR <0.2. Gene signatures were downloaded from the MSigDB, Molecular Signature Database of Broad Institute.
FDR, false discovery rate; NES, normalized enrichment score.