Current prognostic models for MF
| Variable . | IPSS . | DIPSS . | DIPSS-plus . |
|---|---|---|---|
| Age > 65 years | + | + | + |
| Constitutional symptoms | + | + | + |
| Hb < 10 g/dL | + | + | + |
| Leukocytes > 25 × 109/L | + | + | + |
| Blood blasts ≥ 1% | + | + | + |
| Platelets < 100 × 109/L | + | ||
| Red blood cell transfusion need | + | ||
| Unfavorable karyotype: +8, −7/7q-, −5/5q-, i17q, 12p-, 11q23 rearrangement | + | ||
| Score: | 1 point each | 1 point each (Hb: 2 points) | The sum of the patient’s DIPSS score (int-1: 1 point; int-2: 2 points; high: 3 points) plus 1 additional point for each of the following: platelets < 100 × 109/L; unfavorable karyotype; transfusion need |
| Variable . | IPSS . | DIPSS . | DIPSS-plus . |
|---|---|---|---|
| Age > 65 years | + | + | + |
| Constitutional symptoms | + | + | + |
| Hb < 10 g/dL | + | + | + |
| Leukocytes > 25 × 109/L | + | + | + |
| Blood blasts ≥ 1% | + | + | + |
| Platelets < 100 × 109/L | + | ||
| Red blood cell transfusion need | + | ||
| Unfavorable karyotype: +8, −7/7q-, −5/5q-, i17q, 12p-, 11q23 rearrangement | + | ||
| Score: | 1 point each | 1 point each (Hb: 2 points) | The sum of the patient’s DIPSS score (int-1: 1 point; int-2: 2 points; high: 3 points) plus 1 additional point for each of the following: platelets < 100 × 109/L; unfavorable karyotype; transfusion need |
IPSS: low risk, 0 points; intermediate-1 risk, 1 point; intermediate-2 risk, 2 points; high risk, 3 to 5 points; DIPPS: low risk, 0 points; intermediate-1 risk, 1 to 2 points; intermediate-2 risk, 3 to 4 points; high risk, 5 to 6 points; DIPPS-plus: low risk, 0 points; intermediate-1 risk, 1 point; intermediate-2 risk, 2 to 3 points; high risk, 4 to 6 points.