Table 3

Association of gene mutations with response rate in logistic regression analysis

Mutated gene*Unadjusted OR (95% CI)P valueAdjusted† OR (95% CI)P value
Mutations with VAF ≥10% 
 TET2-mut vs TET2-WT 1.99 (1.05, 3.80) .036 1.98 (1.02, 3.85) .044 
 ASXL-mut vs ASXL1-WT 0.69 (0.40, 1.20) .19 0.68 (0.38, 1.19) .17 
 TET2-mut + ASXL1-WT vs other 3.65 (1.38, 9.67) .009 3.64 (1.35, 9.79) .011 
 TET2-mut + ASXL1-WT vs both WT 3.40 (1.24, 9.35) .011 3.36 (1.20, 9.38) .013 
 TET2-WT + ASXL1-mut vs both WT 0.77 (0.41, 1.46) .35 0.80 (0.39, 1.46) .39 
 TET2-mut + ASXL1-mut vs both WT 1.11 (0.48, 2.61) .62 1.07 (0.44, 2.61) .59 
 CBL-mut vs CBL-WT 0.27 (0.06, 1.29) .10 0.28 (0.06, 1.40) .12 
Including all mutations 
 TET- mut vs TET2-WT 1.58 (0.86, 2.89) .14 1.60 (0.85, 3.02) .15 
 ASXL1-mut vs ASXL1-WT 0.77 (0.45, 1.32) .34 0.74 (0.42, 1.30) .29 
 TET2-mut + ASXL1-WT vs other 2.37 (1.00, 5.58) .049 2.40 (0.99, 5.79) .051 
 TET2-mut + ASXL1-WT vs both WT 2.27 (0.91, 5.63) .055 2.27 (0.89, 5.79) .056 
 TET2-WT + ASXL1-mut vs both WT 0.86 (0.45, 1.64) .16 0.84 (0.43, 1.62) .15 
 TET2-mut + ASXL1-mut vs both WT 1.06 (0.47, 2.38) .67 1.04 (0.45, 2.44) .68 
 CBL-mut vs CBL-WT 0.17 (0.04, 0.79) .023 0.18 (0.04, 0.82) .027 
Mutated gene*Unadjusted OR (95% CI)P valueAdjusted† OR (95% CI)P value
Mutations with VAF ≥10% 
 TET2-mut vs TET2-WT 1.99 (1.05, 3.80) .036 1.98 (1.02, 3.85) .044 
 ASXL-mut vs ASXL1-WT 0.69 (0.40, 1.20) .19 0.68 (0.38, 1.19) .17 
 TET2-mut + ASXL1-WT vs other 3.65 (1.38, 9.67) .009 3.64 (1.35, 9.79) .011 
 TET2-mut + ASXL1-WT vs both WT 3.40 (1.24, 9.35) .011 3.36 (1.20, 9.38) .013 
 TET2-WT + ASXL1-mut vs both WT 0.77 (0.41, 1.46) .35 0.80 (0.39, 1.46) .39 
 TET2-mut + ASXL1-mut vs both WT 1.11 (0.48, 2.61) .62 1.07 (0.44, 2.61) .59 
 CBL-mut vs CBL-WT 0.27 (0.06, 1.29) .10 0.28 (0.06, 1.40) .12 
Including all mutations 
 TET- mut vs TET2-WT 1.58 (0.86, 2.89) .14 1.60 (0.85, 3.02) .15 
 ASXL1-mut vs ASXL1-WT 0.77 (0.45, 1.32) .34 0.74 (0.42, 1.30) .29 
 TET2-mut + ASXL1-WT vs other 2.37 (1.00, 5.58) .049 2.40 (0.99, 5.79) .051 
 TET2-mut + ASXL1-WT vs both WT 2.27 (0.91, 5.63) .055 2.27 (0.89, 5.79) .056 
 TET2-WT + ASXL1-mut vs both WT 0.86 (0.45, 1.64) .16 0.84 (0.43, 1.62) .15 
 TET2-mut + ASXL1-mut vs both WT 1.06 (0.47, 2.38) .67 1.04 (0.45, 2.44) .68 
 CBL-mut vs CBL-WT 0.17 (0.04, 0.79) .023 0.18 (0.04, 0.82) .027 
*

Reference group is listed second.

†

Adjusted for sex, age (<70, ≥70 y), IPSS (Low/Int1 vs Int2/High), and treatment (AZA alone vs DEC alone vs DEC + other); none of the Hosmer and Lemeshow tests indicated a lack of fit for each model.

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