Association of gene mutations with response rate in logistic regression analysis
Mutated gene* . | Unadjusted OR (95% CI) . | P value . | Adjusted† OR (95% CI) . | P value . |
---|---|---|---|---|
Mutations with VAF ≥10% | ||||
TET2-mut vs TET2-WT | 1.99 (1.05, 3.80) | .036 | 1.98 (1.02, 3.85) | .044 |
ASXL-mut vs ASXL1-WT | 0.69 (0.40, 1.20) | .19 | 0.68 (0.38, 1.19) | .17 |
TET2-mut + ASXL1-WT vs other | 3.65 (1.38, 9.67) | .009 | 3.64 (1.35, 9.79) | .011 |
TET2-mut + ASXL1-WT vs both WT | 3.40 (1.24, 9.35) | .011 | 3.36 (1.20, 9.38) | .013 |
TET2-WT + ASXL1-mut vs both WT | 0.77 (0.41, 1.46) | .35 | 0.80 (0.39, 1.46) | .39 |
TET2-mut + ASXL1-mut vs both WT | 1.11 (0.48, 2.61) | .62 | 1.07 (0.44, 2.61) | .59 |
CBL-mut vs CBL-WT | 0.27 (0.06, 1.29) | .10 | 0.28 (0.06, 1.40) | .12 |
Including all mutations | ||||
TET- mut vs TET2-WT | 1.58 (0.86, 2.89) | .14 | 1.60 (0.85, 3.02) | .15 |
ASXL1-mut vs ASXL1-WT | 0.77 (0.45, 1.32) | .34 | 0.74 (0.42, 1.30) | .29 |
TET2-mut + ASXL1-WT vs other | 2.37 (1.00, 5.58) | .049 | 2.40 (0.99, 5.79) | .051 |
TET2-mut + ASXL1-WT vs both WT | 2.27 (0.91, 5.63) | .055 | 2.27 (0.89, 5.79) | .056 |
TET2-WT + ASXL1-mut vs both WT | 0.86 (0.45, 1.64) | .16 | 0.84 (0.43, 1.62) | .15 |
TET2-mut + ASXL1-mut vs both WT | 1.06 (0.47, 2.38) | .67 | 1.04 (0.45, 2.44) | .68 |
CBL-mut vs CBL-WT | 0.17 (0.04, 0.79) | .023 | 0.18 (0.04, 0.82) | .027 |
Mutated gene* . | Unadjusted OR (95% CI) . | P value . | Adjusted† OR (95% CI) . | P value . |
---|---|---|---|---|
Mutations with VAF ≥10% | ||||
TET2-mut vs TET2-WT | 1.99 (1.05, 3.80) | .036 | 1.98 (1.02, 3.85) | .044 |
ASXL-mut vs ASXL1-WT | 0.69 (0.40, 1.20) | .19 | 0.68 (0.38, 1.19) | .17 |
TET2-mut + ASXL1-WT vs other | 3.65 (1.38, 9.67) | .009 | 3.64 (1.35, 9.79) | .011 |
TET2-mut + ASXL1-WT vs both WT | 3.40 (1.24, 9.35) | .011 | 3.36 (1.20, 9.38) | .013 |
TET2-WT + ASXL1-mut vs both WT | 0.77 (0.41, 1.46) | .35 | 0.80 (0.39, 1.46) | .39 |
TET2-mut + ASXL1-mut vs both WT | 1.11 (0.48, 2.61) | .62 | 1.07 (0.44, 2.61) | .59 |
CBL-mut vs CBL-WT | 0.27 (0.06, 1.29) | .10 | 0.28 (0.06, 1.40) | .12 |
Including all mutations | ||||
TET- mut vs TET2-WT | 1.58 (0.86, 2.89) | .14 | 1.60 (0.85, 3.02) | .15 |
ASXL1-mut vs ASXL1-WT | 0.77 (0.45, 1.32) | .34 | 0.74 (0.42, 1.30) | .29 |
TET2-mut + ASXL1-WT vs other | 2.37 (1.00, 5.58) | .049 | 2.40 (0.99, 5.79) | .051 |
TET2-mut + ASXL1-WT vs both WT | 2.27 (0.91, 5.63) | .055 | 2.27 (0.89, 5.79) | .056 |
TET2-WT + ASXL1-mut vs both WT | 0.86 (0.45, 1.64) | .16 | 0.84 (0.43, 1.62) | .15 |
TET2-mut + ASXL1-mut vs both WT | 1.06 (0.47, 2.38) | .67 | 1.04 (0.45, 2.44) | .68 |
CBL-mut vs CBL-WT | 0.17 (0.04, 0.79) | .023 | 0.18 (0.04, 0.82) | .027 |