CRS revised grading system
| Grade . | Toxicity . |
|---|---|
| Grade 1 | Symptoms are not life threatening and require symptomatic treatment only, eg, fever, nausea, fatigue, headache, myalgias, malaise |
| Grade 2 | Symptoms require and respond to moderate intervention |
| Oxygen requirement <40% or | |
| Hypotension responsive to fluids or low dose2 of one vasopressor or | |
| Grade 2 organ toxicity | |
| Grade 3 | Symptoms require and respond to aggressive intervention |
| Oxygen requirement ≥40% or | |
| Hypotension requiring high dose* or multiple vasopressors or | |
| Grade 3 organ toxicity or grade 4 transaminitis | |
| Grade 4 | Life-threatening symptoms |
| Requirement for ventilator support or | |
| Grade 4 organ toxicity (excluding transaminitis) | |
| Grade 5 | Death |
| Grade . | Toxicity . |
|---|---|
| Grade 1 | Symptoms are not life threatening and require symptomatic treatment only, eg, fever, nausea, fatigue, headache, myalgias, malaise |
| Grade 2 | Symptoms require and respond to moderate intervention |
| Oxygen requirement <40% or | |
| Hypotension responsive to fluids or low dose2 of one vasopressor or | |
| Grade 2 organ toxicity | |
| Grade 3 | Symptoms require and respond to aggressive intervention |
| Oxygen requirement ≥40% or | |
| Hypotension requiring high dose* or multiple vasopressors or | |
| Grade 3 organ toxicity or grade 4 transaminitis | |
| Grade 4 | Life-threatening symptoms |
| Requirement for ventilator support or | |
| Grade 4 organ toxicity (excluding transaminitis) | |
| Grade 5 | Death |
Grades 2-4 refer to CTCAE v4.0 grading.
High-dose vasopressor doses shown in Table 3.